Enantioselective synthesis of C2-symmetric spirobilactams via Pd-catalyzed intramolecular double N-arylation

Organic Letters

Volumn 11, Issue 7, 2009, Pages 1483-1486

  Takenaka, Kazuhiro ^a   Itoh, Noriyuki ^a   Sasai, Hiroaki ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 64349084024     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol900016g     Document Type: Article

References (43)

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38. See Supporting Information for details.
39. The conversion of 2a-Br was 10% in the absence of (S)-BINAP after 3 h, whereas that of 2a-I reached >95% under the same conditions.
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43. 3 (1.4 equiv/Br) in toluene at 50 °C for 48 h. For details, see Supporting Information.