Enantioselective glyoxylate-ene reaction using a novel spiro bis(isoxazoline) ligand in copper catalysis

Tetrahedron Asymmetry

Volumn 18, Issue 3, 2007, Pages 372-376

  Wakita, Kazuhiko ^a   Bajracharya, Gan B ^a   Arai, Midori A ^a   Takizawa, Shinobu ^a   Suzuki, Takeyuki ^a   Sasai, Hiroaki ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE; COPPER; GLYOXYLIC ACID DERIVATIVE; ISOXAZOLINE DERIVATIVE; SPIRO BIS (ISOXAZOLINE)LIGAND; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; ENANTIOSELECTIVITY; PRIORITY JOURNAL; SYNTHESIS;

EID: 33847657139     PISSN: 09574166     EISSN: 1362511X     Source Type: Journal    
DOI: 10.1016/j.tetasy.2007.02.004     Document Type: Article

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56. 2 (1:1) at rt for 24 h.
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59. 4 and concentrated. The residue was purified by silica gel column chromatography (hexane/ethyl acetate = 5/1) to give product 7. The enantiomeric excess of the products was determined by HPLC analysis using chiral stationary phase column (Daicel Chiralpak AS, hexane/i-PrOH = 10/1, flow rate = 0.5 mL/min).