Catalytic enantioselective synthesis of key intermediates for NET inhibitors using atropisomeric lactam chemistry

Tetrahedron Letters

Volumn 49, Issue 3, 2008, Pages 471-474

  Kitagawa, Osamu ^a   Kurihara, Daisuke ^a   Tanabe, Hajime ^a   Shibuya, Taichi ^a   Taguchi, Takeo ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LACTAM; NORADRENALIN TRANSPORTER;

ALKYLATION; ARTICLE; ARYLATION; CATALYSIS; CHEMICAL REACTION; ENANTIOSELECTIVITY; HYDRATION; REACTION ANALYSIS; SYNTHESIS;

EID: 37349106060     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.11.101     Document Type: Article

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42. Interestingly, the use of (R)-DTBM-SEGPHOS which gave the best results in intermolecular reaction, was not effective in the intramolecular reaction with 1a (12% yield, 0% ee).
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45. 4
46. 3): δ 7.50 (2H, t, J = 7.5 Hz), 7.40 (1H, t, J = 7.5 Hz), 7.16-7.20 (3H, m), 7.03 (1H, dt, J = 1.5, 7.5 Hz), 6.98 (1H, dt, J = 1.0, 7.5 Hz), 6.28...