메뉴 건너뛰기




Volumn 19, Issue 4, 2009, Pages 458-468

Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation

Author keywords

C53; Cdk1; Checkpoint kinases

Indexed keywords

CDK5RAP3 PROTEIN, HUMAN; CHECKPOINT KINASE 1; CYCLIN B; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NERVE PROTEIN; PROTEIN KINASE; SIGNAL PEPTIDE;

EID: 64149116777     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2009.14     Document Type: Article
Times cited : (51)

References (37)
  • 1
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 2004; 73:39-85.
    • (2004) Annu Rev Biochem , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 2
    • 9244229490 scopus 로고    scopus 로고
    • cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein
    • Cimprich KA, Shin TB, Keith CT, Schreiber SL. cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc Natl Acad Sci USA 1996; 93:2850-2855.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2850-2855
    • Cimprich, K.A.1    Shin, T.B.2    Keith, C.T.3    Schreiber, S.L.4
  • 3
    • 0031466618 scopus 로고    scopus 로고
    • Ataxia-telangiectasia and the Nijmegen breakage syndrome: Related disorders but genes apart
    • Shiloh Y. Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart. Annu Rev Genet 1997; 31:635-662.
    • (1997) Annu Rev Genet , vol.31 , pp. 635-662
    • Shiloh, Y.1
  • 4
    • 0030768948 scopus 로고    scopus 로고
    • Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase
    • Furnari B, Rhind N, Russell P. Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase. Science 1997; 277:1495-1497.
    • (1997) Science , vol.277 , pp. 1495-1497
    • Furnari, B.1    Rhind, N.2    Russell, P.3
  • 5
    • 0032484084 scopus 로고    scopus 로고
    • Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
    • Matsuoka S, Huang M, Elledge SJ. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 1998; 282:1893-1897.
    • (1998) Science , vol.282 , pp. 1893-1897
    • Matsuoka, S.1    Huang, M.2    Elledge, S.J.3
  • 6
    • 17644432403 scopus 로고    scopus 로고
    • Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
    • Liu Q, Guntuku S, Cui XS, et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 2000; 14:1448-1459.
    • (2000) Genes Dev , vol.14 , pp. 1448-1459
    • Liu, Q.1    Guntuku, S.2    Cui, X.S.3
  • 7
    • 0034142034 scopus 로고    scopus 로고
    • The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
    • Shieh SY, Ahn J, Tamai K, Taya Y, Prives C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 2000; 14:289-300.
    • (2000) Genes Dev , vol.14 , pp. 289-300
    • Shieh, S.Y.1    Ahn, J.2    Tamai, K.3    Taya, Y.4    Prives, C.5
  • 8
    • 0034659341 scopus 로고    scopus 로고
    • Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice
    • Takai H, Tominaga K, Motoyama N, et al.. Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev 2000; 14:1439-1447.
    • (2000) Genes Dev , vol.14 , pp. 1439-1447
    • Takai, H.1    Tominaga, K.2    Motoyama, N.3
  • 9
    • 0034102337 scopus 로고    scopus 로고
    • ATR disruption leads to chromosomal fragmentation and early embryonic lethality
    • Brown EJ, Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 2000; 14:397-402.
    • (2000) Genes Dev , vol.14 , pp. 397-402
    • Brown, E.J.1    Baltimore, D.2
  • 10
    • 20244388673 scopus 로고    scopus 로고
    • Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
    • Syljuasen RG, Sorensen CS, Hansen LT, et al. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol 2005; 25:3553-3562.
    • (2005) Mol Cell Biol , vol.25 , pp. 3553-3562
    • Syljuasen, R.G.1    Sorensen, C.S.2    Hansen, L.T.3
  • 11
    • 14644400361 scopus 로고    scopus 로고
    • Checking out the centrosome
    • Kramer A, Lukas J, Bartek J. Checking out the centrosome. Cell Cycle 2004; 3:1390-1393.
    • (2004) Cell Cycle , vol.3 , pp. 1390-1393
    • Kramer, A.1    Lukas, J.2    Bartek, J.3
  • 14
    • 0037322744 scopus 로고    scopus 로고
    • Active cyclin B1-Cdk1 first appears on centrosomes in prophase
    • Jackman M, Lindon C, Nigg EA, Pines J. Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat Cell Biol 2003; 5:143-148.
    • (2003) Nat Cell Biol , vol.5 , pp. 143-148
    • Jackman, M.1    Lindon, C.2    Nigg, E.A.3    Pines, J.4
  • 15
    • 0141429171 scopus 로고    scopus 로고
    • Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells
    • Hirota T, Kunitoku N, Sasayama T, et al. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 2003; 114:585-598.
    • (2003) Cell , vol.114 , pp. 585-598
    • Hirota, T.1    Kunitoku, N.2    Sasayama, T.3
  • 16
    • 3042734502 scopus 로고    scopus 로고
    • Phosphorylation of CDC25B by aurora-A at the centrosome contributes to the G2-M transition
    • Dutertre S, Cazales M, Quaranta M, et al. Phosphorylation of CDC25B by aurora-A at the centrosome contributes to the G2-M transition. J Cell Sci 2004; 117:2523-2531.
    • (2004) J Cell Sci , vol.117 , pp. 2523-2531
    • Dutertre, S.1    Cazales, M.2    Quaranta, M.3
  • 17
    • 4444345565 scopus 로고    scopus 로고
    • Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase
    • Kramer A, Mailand N, Lukas C, et al. Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat Cell Biol 2004; 6:884-891.
    • (2004) Nat Cell Biol , vol.6 , pp. 884-891
    • Kramer, A.1    Mailand, N.2    Lukas, C.3
  • 18
    • 0037424258 scopus 로고    scopus 로고
    • Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
    • Tsvetkov L, Xu X, Li J, Stern DF. Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. J Biol Chem 2003; 278:8468-8475.
    • (2003) J Biol Chem , vol.278 , pp. 8468-8475
    • Tsvetkov, L.1    Xu, X.2    Li, J.3    Stern, D.F.4
  • 19
    • 0033964878 scopus 로고    scopus 로고
    • Cloning of three novel neuronal Cdk5 activator binding proteins
    • Ching YP, Qi Z, Wang JH. Cloning of three novel neuronal Cdk5 activator binding proteins. Gene 2000; 242:285-294.
    • (2000) Gene , vol.242 , pp. 285-294
    • Ching, Y.P.1    Qi, Z.2    Wang, J.H.3
  • 20
    • 30744456521 scopus 로고    scopus 로고
    • A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2
    • Wang J, He X, Luo Y, Yarbrough WG. A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2. Biochem J 2006; 393:489-501.
    • (2006) Biochem J , vol.393 , pp. 489-501
    • Wang, J.1    He, X.2    Luo, Y.3    Yarbrough, W.G.4
  • 21
    • 20144383299 scopus 로고    scopus 로고
    • Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint
    • Jiang H, Luo S, Li H. Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. J Biol Chem 2005; 280:20651-20659.
    • (2005) J Biol Chem , vol.280 , pp. 20651-20659
    • Jiang, H.1    Luo, S.2    Li, H.3
  • 22
    • 0035930537 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
    • Ward IM, Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem 2001; 276:47759-47762.
    • (2001) J Biol Chem , vol.276 , pp. 47759-47762
    • Ward, I.M.1    Chen, J.2
  • 23
    • 1542365321 scopus 로고    scopus 로고
    • Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains
    • Ng CP, Lee HC, Ho CW, et al. Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains. J Biol Chem 2004; 279:8808-8819.
    • (2004) J Biol Chem , vol.279 , pp. 8808-8819
    • Ng, C.P.1    Lee, H.C.2    Ho, C.W.3
  • 24
    • 33645800984 scopus 로고    scopus 로고
    • Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1)
    • Shiromizu T, Goto H, Tomono Y, et al. Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1). Genes Cells 2006; 11:477-485.
    • (2006) Genes Cells , vol.11 , pp. 477-485
    • Shiromizu, T.1    Goto, H.2    Tomono, Y.3
  • 25
    • 31344482199 scopus 로고    scopus 로고
    • Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53
    • Yin X, Warner DR, Roberts EA, Pisano MM, Greene RM. Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53. Int J Mol Med 2005; 16:251-256.
    • (2005) Int J Mol Med , vol.16 , pp. 251-256
    • Yin, X.1    Warner, D.R.2    Roberts, E.A.3    Pisano, M.M.4    Greene, R.M.5
  • 26
    • 0038418869 scopus 로고    scopus 로고
    • Chk1 and Chk2 kinases in checkpoint control and cancer
    • Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 2003; 3:421-429.
    • (2003) Cancer Cell , vol.3 , pp. 421-429
    • Bartek, J.1    Lukas, J.2
  • 27
    • 0034312277 scopus 로고    scopus 로고
    • Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
    • Guo Z, Kumagai A, Wang SX, Dunphy WG. Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev 2000; 14:2745-2756.
    • (2000) Genes Dev , vol.14 , pp. 2745-2756
    • Guo, Z.1    Kumagai, A.2    Wang, S.X.3    Dunphy, W.G.4
  • 28
    • 28244497051 scopus 로고    scopus 로고
    • Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe
    • Niida H, Tsuge S, Katsuno Y, Konishi A, Takeda N, Nakanishi M. Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe. J Biol Chem 2005; 280:39246-39252.
    • (2005) J Biol Chem , vol.280 , pp. 39246-39252
    • Niida, H.1    Tsuge, S.2    Katsuno, Y.3    Konishi, A.4    Takeda, N.5    Nakanishi, M.6
  • 29
    • 18844405191 scopus 로고    scopus 로고
    • PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
    • Lu X, Nannenga B, Donehower LA. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev 2005; 19:1162-1174.
    • (2005) Genes Dev , vol.19 , pp. 1162-1174
    • Lu, X.1    Nannenga, B.2    Donehower, L.A.3
  • 30
    • 33745206498 scopus 로고    scopus 로고
    • Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
    • Fujimoto H, Onishi N, Kato N, et al. Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase. Cell Death Differ 2006; 13:1170-1180.
    • (2006) Cell Death Differ , vol.13 , pp. 1170-1180
    • Fujimoto, H.1    Onishi, N.2    Kato, N.3
  • 31
    • 33847382384 scopus 로고    scopus 로고
    • The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase
    • Oliva-Trastoy M, Berthonaud V, Chevalier A, et al. The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase. Oncogene 2007; 26:1449-1458.
    • (2007) Oncogene , vol.26 , pp. 1449-1458
    • Oliva-Trastoy, M.1    Berthonaud, V.2    Chevalier, A.3
  • 32
    • 21644447887 scopus 로고    scopus 로고
    • Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit
    • Dozier C, Bonyadi M, Baricault L, Tonasso L, Darbon JM. Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit. Biol Cell 2004; 96:509-517.
    • (2004) Biol Cell , vol.96 , pp. 509-517
    • Dozier, C.1    Bonyadi, M.2    Baricault, L.3    Tonasso, L.4    Darbon, J.M.5
  • 33
    • 4344678792 scopus 로고    scopus 로고
    • G1 and S-phase checkpoints, chromosome instability, and cancer
    • Nojima H. G1 and S-phase checkpoints, chromosome instability, and cancer. Methods Mol Biol 2004; 280:3-49.
    • (2004) Methods Mol Biol , vol.280 , pp. 3-49
    • Nojima, H.1
  • 34
    • 34548236254 scopus 로고    scopus 로고
    • LZAP, a putative tumor suppressor, selectively inhibits NFkappaB
    • Wang J, An H, Mayo MW, Baldwin AS, Yarbrough WG. LZAP, a putative tumor suppressor, selectively inhibits NFkappaB. Cancer Cell 2007; 12:239-251.
    • (2007) Cancer Cell , vol.12 , pp. 239-251
    • Wang, J.1    An, H.2    Mayo, M.W.3    Baldwin, A.S.4    Yarbrough, W.G.5
  • 35
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou BB, SJ Elledge. The DNA damage response: putting checkpoints in perspective. Nature 2000; 408:433-439.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 36
    • 1542725073 scopus 로고    scopus 로고
    • Targeting the checkpoint kinases: Chemosensitization versus chemoprotection
    • Zhou BB, Bartek J. Targeting the checkpoint kinases: chemosensitization versus chemoprotection. Nat Rev Cancer 2004; 4:216-225.
    • (2004) Nat Rev Cancer , vol.4 , pp. 216-225
    • Zhou, B.B.1    Bartek, J.2
  • 37
    • 0030881653 scopus 로고    scopus 로고
    • Activation of caspase-2 in apoptosis
    • Li H, Bergeron L, Cryns V, et al. Activation of caspase-2 in apoptosis. J Biol Chem 1997; 272:21010-21017.
    • (1997) J Biol Chem , vol.272 , pp. 21010-21017
    • Li, H.1    Bergeron, L.2    Cryns, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.