The immune control of HTLV-1 infection: Selection forces and dynamics

Frontiers in Bioscience

Volumn 14, Issue 8, 2009, Pages 2889-2903

  Bangham, Charles R M ^a   Meekings, Kiran ^a   Toulza, Frederic ^a   Nejmeddine, Mohamed ^a   Majorovits, Endre ^b   Asquith, Becca ^a   Taylor, Graham P ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

CTL; Dynamics; HTLV 1; Immune response; Persistent viral infection; Retrovirus; Review

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T-LYMPHOTROPIC VIRUS 1;

CYTOTOXIC T LYMPHOCYTE; GENETICS; GENOTYPE; HUMAN; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS INFECTION; IMMUNOLOGY; REVIEW; SPASTIC PARAPLEGIA; VIROLOGY; VIRUS GENOME; VIRUS LOAD;

GENOME, VIRAL; GENOTYPE; HTLV-I INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; PARAPARESIS, TROPICAL SPASTIC; T-LYMPHOCYTES, CYTOTOXIC; VIRAL LOAD;

EID: 63849171483     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2735/3420     Document Type: Article

References (87)

1. A. Gessain, F. Saal, O. Gout, M. T. Daniel, G. Flandrin, G. de The, J. Peries and F. Sigaux: High human T-cell lymphotropic virus type I proviral DNA load with polyclonal integration in peripheral blood mononuclear cells of French West Indian, Guianese, and African patients with tropical spastic paraparesis. Blood, 75 (2), 428-33 (1990). (Pubitemid 20035274)
2. J. Kira, Y. Koyanagi, T. Yamada, Y. Itoyama, I. Goto, N. Yamamoto, H. Sasaki and Y. Sakaki: Increased HTLV-I proviral DNA in HTLV-I-associated myelopathy: a quantitative polymerase chain reaction study. Ann Neurol, 29 (2), 194-201 (1991).
3. M. Yoshida, J. Inoue, J. Fujisawa and M. Seiki: Molecular mechanisms of regulation of HTLV-1 gene expression and its association with leukemogenesis. Genome, 31 (2), 662-7 (1989). (Pubitemid 20118454)
4. M. Nagai, K. Usuku, W. Matsumoto, D. Kodama, N. Takenouchi, T. Moritoyo, S. Hashiguchi, M. Ichinose, C. R. Bangham, S. Izumo and M. Osame: Analysis of HTLV-I proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM/TSP. J Neurovirol, 4 (6), 586-93 (1998). (Pubitemid 29042065)
5. G. P. Taylor, J. H. Tosswill, E. Matutes, S. Daenke, S. Hall, B. J. Bain, R. Davis, D. Thomas, M. Rossor, C. R. Bangham and J. N. Weber: Prospective study of HTLV-I infection in an initially asymptomatic cohort. J Acquir Immune Defic Syndr, 22 (1), 92-100 (1999). (Pubitemid 29486915)
6. T. Matsuzaki, M. Nakagawa, M. Nagai, K. Usuku, I. Higuchi, K. Arimura, H. Kubota, S. Izumo, S. Akiba and M. Osame: HTLV-I proviral load correlates with progression of motor disability in HAM/TSP: analysis of 239 HAM/TSP patients including 64 patients followed up for 10 years. J Neurovirol, 7 (3), 228-34 (2001). (Pubitemid 32685257)
7. G. P. Taylor, S. E. Hall, S. Navarrete, C. A. Michie, R. Davis, A. D. Witkover, M. Rossor, M. A. Nowak, P. Rudge, E. Matutes, C. R. Bangham and J. N. Weber: Effect of lamivudine on human T-cell leukemia virus type 1 (HTLV-1) DNA copy number, T-cell phenotype, and anti-tax cytotoxic T-cell frequency in patients with HTLV-1-associated myelopathy. J Virol, 73 (12), 10289-95. (1999).
8. A. Oxenius and B. Hirschel: Structured treatment interruptions in HIV infection: benefit or disappointment? Expert Rev Anti Infect Ther, 1 (1), 129- 39 (2003). (Pubitemid 38735734)
9. S. Daenke, S. Nightingale, J. K. Cruickshank and C. R. Bangham: Sequence variants of human T-cell lymphotropic virus type I from patients with tropical spastic paraparesis and adult T-cell leukemia do not distinguish neurological from leukemic isolates. J Virol, 64 (3), 1278-82 (1990). (Pubitemid 20087768)
10. T. Kinoshita, A. Tsujimoto and K. Shimotohno: Sequence variations in LTR and env regions of HTLV-I do not discriminate between the virus from patients with HTLV-I-associated myelopathy and adult T-cell leukemia. Int J Cancer, 47 (4), 491-5 (1991).
11. F. Komurian, F. Pelloquin and G. de The: In vivo genomic variability of human T-cell leukemia virus type I depends more upon geography than upon pathologies. J Virol, 65 (7), 3770-8 (1991).
12. J. P. Slattery, G. Franchini and A. Gessain: Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses. Genome Res, 9 (6), 525-40 (1999). (Pubitemid 29361269)
13. S. Jacobson, H. Shida, D. E. McFarlin, A. S. Fauci and S. Koenig: Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease. Nature, 348 (6298), 245-8 (1990).
14. C. E. Parker, S. Daenke, S. Nightingale and C. R. Bangham: Activated, HTLV-1-specific cytotoxic Tlymphocytes are found in healthy seropositives as well as in patients with tropical spastic paraparesis. Virology, 188 (2), 628-36 (1992).
15. C. E. Parker, S. Nightingale, G. P. Taylor, J. Weber and C. R. Bangham: Circulating anti-Tax cytotoxic T lymphocytes from human T-cell leukemia virus type Iinfected people, with and without tropical spastic paraparesis, recognize multiple epitopes simultaneously. J Virol, 68 (5), 2860-8 (1994).
16. C. R. Bangham: The immune control and cell-to-cell spread of human T-lymphotropic virus type 1. J Gen Virol, 84 (Pt 12), 3177-89 (2003). (Pubitemid 37540747)
17. B. Asquith, A. J. Mosley, A. Barfield, S. E. Marshall, A. Heaps, P. Goon, E. Hanon, Y. Tanaka, G. P. Taylor and C. R. Bangham: A functional CD8+ cell assay reveals individual variation in CD8+ cell antiviral efficacy and explains differences in human Tlymphotropic virus type 1 proviral load. J Gen Virol, 86 (Pt 5), 1515-23 (2005). (Pubitemid 40613271)
18. E. Hanon, S. Hall, G. P. Taylor, M. Saito, R. Davis, Y. Tanaka, K. Usuku, M. Osame, J. N. Weber and C. R. Bangham: Abundant tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes. Blood, 95 (4), 1386-92 (2000). (Pubitemid 30099851)
19. C. R. Bangham and M. Osame: Cellular immune response to HTLV-1. Oncogene, 24 (39), 6035-46 (2005). (Pubitemid 43086121)
20. K. J. Jeffery, A. A. Siddiqui, M. Bunce, A. L. Lloyd, A. M. Vine, A. D. Witkover, S. Izumo, K. Usuku, K. I. Welsh, M. Osame and C. R. Bangham: The influence of HLA class I alleles and heterozygosity on the outcome of human T cell lymphotropic virus type I infection. J Immunol, 165 (12), 7278-84 (2000). (Pubitemid 32001207)
21. K. J. Jeffery, K. Usuku, S. E. Hall, W. Matsumoto, G. P. Taylor, J. Procter, M. Bunce, G. S. Ogg, K. I. Welsh, J. N. Weber, A. L. Lloyd, M. A. Nowak, M. Nagai, D. Kodama, S. Izumo, M. Osame and C. R. Bangham: HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy. Proc Natl Acad Sci U S A, 96 (7), 3848-53 (1999). (Pubitemid 29168999)
22. A. M. Vine, A. D. Witkover, A. L. Lloyd, K. J. Jeffery, A. Siddiqui, S. E. Marshall, M. Bunce, N. Eiraku, S. Izumo, K. Usuku, M. Osame and C. R. Bangham: Polygenic control of human T lymphotropic virus type I (HTLV-I) provirus load and the risk of HTLV-I-associated myelopathy/tropical spastic paraparesis. J Infect Dis, 186 (7), 932-9 (2002).
23. C. R. M. Bangham: Human T-lymphotropic virus type 1 (HTLV-1)-associated diseases. In: Genetic Susceptibility to Infectious Diseases. Ed J. M. M. R. A. Kaslow, A. V. S. Hill. Oxford University Press, Oxford UK (2008).
24. A. M. Vine, A. G. Heaps, L. Kaftantzi, A. Mosley, B. Asquith, A. Witkover, G. Thompson, M. Saito, P. K. Goon, L. Carr, F. Martinez-Murillo, G. P. Taylor and C. R. Bangham: The role of CTLs in persistent viral infection: cytolytic gene expression in CD8+ lymphocytes distinguishes between individuals with a high or low proviral load of human T cell lymphotropic virus type 1. J Immunol, 173 (8), 5121-9 (2004). (Pubitemid 39387795)
25. R. Kubota, K. Hanada, Y. Furukawa, K. Arimura, M. Osame, T. Gojobori and S. Izumo: Genetic stability of human T lymphotropic virus type I despite antiviral pressures by CTLs. J Immunol, 178 (9), 5966-72 (2007). (Pubitemid 46674394)
26. S. Niewiesk, S. Daenke, C. E. Parker, G. Taylor, J. Weber, S. Nightingale and C. R. Bangham: The transactivator gene of human T-cell leukemia virus type I is more variable within and between healthy carriers than patients with tropical spastic paraparesis. J Virol, 68 (10), 6778-81 (1994). (Pubitemid 24294933)
27. P. K. Goon, A. Biancardi, N. Fast, T. Igakura, E. Hanon, A. J. Mosley, B. Asquith, K. G. Gould, S. Marshall, G. P. Taylor and C. R. Bangham: Human T cell lymphotropic virus (HTLV) type-1-specific CD8+ T cells: frequency and immunodominance hierarchy. J Infect Dis, 189 (12), 2294-8 (2004). (Pubitemid 38757203)
28. M. Kannagi, S. Harada, I. Maruyama, H. Inoko, H. Igarashi, G. Kuwashima, S. Sato, M. Morita, M. Kidokoro, M. Sugimoto and et al.: Predominant recognition of human T cell leukemia virus type I (HTLV-I) pX gene products by human CD8+ cytotoxic T cells directed against HTLV-Iinfected cells. Int Immunol, 3 (8), 761-7 (1991).
29. C. R. M. Bangham, Kermode, A. G., Hall, S. E., and Daenke, S.: The cytotoxic T-lymphocyte response to HTLV-I: the main determinant of disease? Seminars in Virology, 7, 41-48 (1996). (Pubitemid 26074079)
30. B. Asquith, Y. Zhang, A. J. Mosley, C. M. de Lara, D. L. Wallace, A. Worth, L. Kaftantzi, K. Meekings, G. E. Griffin, Y. Tanaka, D. F. Tough, P. C. Beverley, G. P. Taylor, D. C. Macallan and C. R. Bangham: In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection. Proc Natl Acad Sci U S A, 104 (19), 8035-40 (2007). (Pubitemid 47185871)
31. B. Asquith and C. R. Bangham: Quantifying HTLV-I dynamics. Immunol Cell Biol, 85, 280-286 (2007). (Pubitemid 46878928)
32. M. Cavrois, A. Gessain, S. Wain-Hobson and E. Wattel: Proliferation of HTLV-1 infected circulating cells in vivo in all asymptomatic carriers and patients with TSP/HAM. Oncogene, 12 (11), 2419-23 (1996). (Pubitemid 26192723)
33. E. Wattel, M. Cavrois, A. Gessain and S. Wain- Hobson: Clonal expansion of infected cells: a way of life for HTLV-I. J Acquir Immune Defic Syndr Hum Retrovirol, 13 Suppl 1, S92-9 (1996).
34. E. Wattel, J. P. Vartanian, C. Pannetier and S. Wain- Hobson: Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy. J Virol, 69 (5), 2863-8 (1995).
35. J. Overbaugh and C. R. Bangham: Selection forces and constraints on retroviral sequence variation. Science, 292 (5519), 1106-9 (2001). (Pubitemid 32440922)
36. F. Mortreux, M. Kazanji, A. S. Gabet, B. de Thoisy and E. Wattel: Two-step nature of human T-cell leukemia virus type 1 replication in experimentally infected squirrel monkeys (Saimiri sciureus). J Virol, 75 (2), 1083-9 (2001). (Pubitemid 32037314)
37. N. E. Mueller, W. A. Blattner: Retroviruses: HTLV. In: Viral infections of humans: epidemiology and control. Ed A. S. a. R. K. Evans. Plenum Medical Press, New York (1997).
38. K. Okochi and H. Sato: Transmission of ATLV (HTLV-I) through blood transfusion. Princess Takamatsu Symp, 15, 129-35 (1984).
39. T. Igakura, J. C. Stinchcombe, P. K. Goon, G. P. Taylor, J. N. Weber, G. M. Griffiths, Y. Tanaka, M. Osame and C. R. Bangham: Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton. Science, 299 (5613), 1713-6 (2003). (Pubitemid 36337193)
40. A. L. Barnard, T. Igakura, Y. Tanaka, G. P. Taylor and C. R. Bangham: Engagement of specific T-cell surface molecules regulates cytoskeletal polarization in HTLV-1- infected lymphocytes. Blood, 106 (3), 988-95 (2005). (Pubitemid 41076444)
41. M. Nejmeddine, A. L. Barnard, Y. Tanaka, G. P. Taylor and C. R. Bangham: Human T-lymphotropic virus, type 1, tax protein triggers microtubule reorientation in the virological synapse. J Biol Chem, 280 (33), 29653-60 (2005). (Pubitemid 41177041)
42. D. Derse, S. A. Hill, P. A. Lloyd, H. Chung and B. A. Morse: Examining human T-lymphotropic virus type 1 infection and replication by cell-free infection with recombinant virus vectors. J Virol, 75 (18), 8461-8. (2001). (Pubitemid 32768950)
43. L. Delamarre, C. Pique, A. R. Rosenberg, V. Blot, M. P. Grange, I. Le Blanc and M. C. Dokhelar: The Y-S-L-I tyrosine-based motif in the cytoplasmic domain of the human T-cell leukemia virus type 1 envelope is essential for cell-to-cell transmission. J Virol, 73 (11), 9659-63 (1999). (Pubitemid 29487127)
44. E. Majorovits, Nejmeddine, M., Tanaka, Y., Taylor, G.P., Fuller, S.D. & Bangham, C.R.M.: Human TLymphotropic Virus-1 Visualized at the Virological Synapse by Electron Tomography. PLoS ONE, 3 (5), e2251 (2008).
45. K. S. Jones, C. Petrow-Sadowski, Y. K. Huang, D. C. Bertolette and F. W. Ruscetti: Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4 (+) T cells. Nat Med, 14 (4), 429-36 (2008). (Pubitemid 351499395)
46. A. Manns, W. J. Miley, R. J. Wilks, O. S. Morgan, B. Hanchard, G. Wharfe, B. Cranston, E. Maloney, S. L. Welles, W. A. Blattner and D. Waters: Quantitative proviral DNA and antibody levels in the natural history of HTLV-I infection. J Infect Dis, 180 (5), 1487-93 (1999). (Pubitemid 29506449)
47. B. Albrecht and M. D. Lairmore: Critical role of human T-lymphotropic virus type 1 accessory proteins in viral replication and pathogenesis. Microbiol Mol Biol Rev, 66 (3), 396-406, table of contents (2002). (Pubitemid 35001136)
48. C. Nicot, M. Dundr, J. M. Johnson, J. R. Fullen, N. Alonzo, R. Fukumoto, G. L. Princler, D. Derse, T. Misteli and G. Franchini: HTLV-1-encoded p30II is a posttranscriptional negative regulator of viral replication. Nat Med, 10 (2), 197-201 (2004). (Pubitemid 38524892)
49. G. Gaudray, F. Gachon, J. Basbous, M. Biard-Piechaczyk, C. Devaux and J. M. Mesnard: The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription. J Virol, 76 (24), 12813-22 (2002). (Pubitemid 35386965)
50. M. H. Cavanagh, S. Landry, B. Audet, C. Arpin-Andre, P. Hivin, M. E. Pare, J. Thete, E. Wattel, S. J. Marriott, J. M. Mesnard and B. Barbeau: HTLV-I antisense transcripts initiating in the 3'LTR are alternatively spliced and polyadenylated. Retrovirology, 3, 15 (2006).
51. J. Matsumoto, T. Ohshima, O. Isono and K. Shimotohno: HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein. Oncogene, 24 (6), 1001-10 (2005). (Pubitemid 40313877)
52. J. M. Mesnard and C. Devaux: Multiple control levels of cell proliferation by human T-cell leukemia virus type 1 Tax protein. Virology, 257 (2), 277-84 (1999). (Pubitemid 29393394)
53. Y. Furukawa, M. Yamashita, K. Usuku, S. Izumo, M. Nakagawa and M. Osame: Phylogenetic subgroups of human T cell lymphotropic virus (HTLV) type I in the tax gene and their association with different risks for HTLV-Iassociated myelopathy/tropical spastic paraparesis. J Infect Dis, 182 (5), 1343-9 (2000).
54. B. Asquith, A. J. Mosley, A. Heaps, Y. Tanaka, G. P. Taylor, A. R. McLean and C. R. Bangham: Quantification of the virus-host interaction in human T lymphotropic virus I infection. Retrovirology, 2, 75 (2005).
55. Y. Yamano, M. Nagai, M. Brennan, C. A. Mora, S. S. Soldan, U. Tomaru, N. Takenouchi, S. Izumo, M. Osame and S. Jacobson: Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8 (+) T cells, and disease severity in HTLV-1-associated myelopathy (HAM/TSP). Blood, 99 (1), 88-94 (2002).
56. A. Lezin, N. Gillet, S. Olindo, A. Signate, N. Grandvaux, O. Verlaeten, G. Belrose, M. de Carvalho Bittencourt, J. Hiscott, B. Asquith, A. Burny, D. Smadja, R. Cesaire and L. Willems: Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients. Blood, 110 (10), 3722-8 (2007). (Pubitemid 350159642)
57. A. J. Mosley, K. N. Meekings, C. McCarthy, D. Shepherd, V. Cerundolo, R. Mazitschek, Y. Tanaka, G. P. Taylor and C. R. Bangham: Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-I infection. Blood (2006).
58. Y. Taniguchi, K. Nosaka, J. Yasunaga, M. Maeda, N. Mueller, A. Okayama and M. Matsuoka: Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms. Retrovirology, 2, 64 (2005).
59. K. N. Meekings, J. Leipzig, F. D. Bushman, G. P. Taylor and C. R. Bangham: HTLV-1 Integration into Transcriptionally Active Genomic Regions Is Associated with Proviral Expression and with HAM/TSP. PLoS Pathog, 4 (3), e1000027 (2008).
60. F. Bushman, M. Lewinski, A. Ciuffi, S. Barr, J. Leipzig, S. Hannenhalli and C. Hoffmann: Genome-wide analysis of retroviral DNA integration. Nat Rev Microbiol, 3 (11), 848-58 (2005). (Pubitemid 41693180)
61. R. S. Mitchell, B. F. Beitzel, A. R. Schroder, P. Shinn, H. Chen, C. C. Berry, J. R. Ecker and F. D. Bushman: Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences. PLoS Biol, 2 (8), E234 (2004).
62. N. D. Collins, G. C. Newbound, B. Albrecht, J. L. Beard, L. Ratner, and M. D. Lairmore. Selective ablation of human T-cell lymphotropic virus type 1 p12I reduces viral infectivity in vivo. Blood, 91 (12), 4701-7 (1998). (Pubitemid 28270320)
63. J. M. Johnson, C. Nicot, J. Fullen, V. Ciminale, L. Casareto, J. C. Mulloy, S. Jacobson and G. Franchini: Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12 (I) protein. J Virol, 75 (13), 6086-94 (2001). (Pubitemid 32553139)
64. D. Wodarz, S. E. Hall, K. Usuku, M. Osame, G. S. Ogg, A. J. McMichael, M. A. Nowak and C. R. Bangham: Cytotoxic T-cell abundance and virus load in human immunodeficiency virus type 1 and human T-cell leukaemia virus type 1. Proc R Soc Lond B Biol Sci, 268 (1473), 1215-21 (2001). (Pubitemid 32622374)
65. R. Kubota, T. Kawanishi, H. Matsubara, A. Manns and S. Jacobson: HTLV-I specific IFN-gamma+ CD8+ lymphocytes correlate with the proviral load in peripheral blood of infected individuals. J Neuroimmunol, 102 (2), 208-15 (2000).
66. R. Kubota, M. Nagai, T. Kawanishi, M. Osame and S. Jacobson: Increased HTLV type 1 tax specific CD8+ cells in HTLV type 1-asociated myelopathy/tropical spastic paraparesis: correlation with HTLV type 1 proviral load. AIDS Res Hum Retroviruses, 16 (16), 1705-9 (2000).
67. G. S. Ogg, X. Jin, S. Bonhoeffer, P. R. Dunbar, M. A. Nowak, S. Monard, J. P. Segal, Y. Cao, S. L. Rowland- Jones, V. Cerundolo, A. Hurley, M. Markowitz, D. D. Ho, D. F. Nixon and A. J. McMichael: Quantitation of HIV-1- specific cytotoxic T lymphocytes and plasma load of viral RNA. Science, 279 (5359), 2103-6. (1998). (Pubitemid 28196353)
68. M. R. Betts, D. R. Ambrozak, D. C. Douek, S. Bonhoeffer, J. M. Brenchley, J. P. Casazza, R. A. Koup and L. J. Picker: Analysis of Total Human Immunodeficiency Virus (HIV)-Specific CD4 (+) and CD8 (+) T-Cell Responses: Relationship to Viral Load in Untreated HIV Infection. J Virol, 75 (24), 11983-91. (2001). (Pubitemid 33115870)
69. A. Zafiropoulos, E. Barnes, C. Piggott and P. Klenerman: Analysis of 'driver' and 'passenger' CD8+ Tcell responses against variable viruses. Proc Biol Sci, 271 Suppl 3, S53-6 (2004). (Pubitemid 38186908)
70. R. Zuniga, A. Lucchetti, P. Galvan, S. Sanchez, C. Sanchez, A. Hernandez, H. Sanchez, N. Frahm, C. H. Linde, H. S. Hewitt, W. Hildebrand, M. Altfeld, T. M. Allen, B. D. Walker, B. T. Korber, T. Leitner, J. Sanchez and C. Brander: Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control. J Virol, 80 (6), 3122-5 (2006). (Pubitemid 43346412)
71. B. Asquith and C. R. Bangham: An introduction to lymphocyte and viral dynamics: the power and limitations of mathematical analysis. Proc R Soc Lond B Biol Sci, 270 (1525), 1651-7 (2003). (Pubitemid 37041284)
72. B. Asquith and C. R. Bangham: How does HTLV-I persist despite a strong cell-mediated immune response? Trends Immunol, 29 (1), 4-11 (2008).
73. S. Sakaguchi and F. Powrie: Emerging challenges in regulatory T cell function and biology. Science, 317 (5838), 627-9 (2007). (Pubitemid 47229955)
74. Y. Belkaid: Regulatory T cells and infection: a dangerous necessity. Nat Rev Immunol, 7 (11), 875-88 (2007). (Pubitemid 350006238)
75. A. L. Kinter, R. Horak, M. Sion, L. Riggin, J. McNally, Y. Lin, R. Jackson, A. O'Shea, G. Roby, C. Kovacs, M. Connors, S. A. Migueles and A. S. Fauci: CD25+ regulatory T cells isolated from HIV-infected individuals suppress the cytolytic and nonlytic antiviral activity of HIV-specific CD8+ T cells in vitro. AIDS Res Hum Retroviruses, 23 (3), 438-50 (2007). (Pubitemid 46608564)
76. S. Tsunemi, T. Iwasaki, T. Imado, S. Higasa, E. Kakishita, T. Shirasaka and H. Sano: Relationship of CD4+CD25+ regulatory T cells to immune status in HIVinfected patients. AIDS, 19 (9), 879-86 (2005). (Pubitemid 40834930)
77. J. Inoue, M. Seiki, T. Taniguchi, S. Tsuru and M. Yoshida: Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. Embo J, 5 (11), 2883-8 (1986).
78. E. Hanon, P. Goon, G. P. Taylor, H. Hasegawa, Y. Tanaka, J. N. Weber and C. R. Bangham: High production of interferon gamma but not interleukin-2 by human Tlymphotropic virus type I-infected peripheral blood mononuclear cells. Blood, 98 (3), 721-6 (2001).
79. S. L. Cross, M. B. Feinberg, J. B. Wolf, N. J. Holbrook, F. Wong-Staal and W. J. Leonard: Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I. Cell, 49 (1), 47-56 (1987).
80. F. Toulza, A. Heaps, Y. Tanaka, G. P. Taylor and C. R. M. Bangham: High frequency of CD4+FoxP3+ cells in HTLV-1 infection: inverse correlation with HTLV-1- specific CTL response. Blood, 111, 5047-5053 (2008).
81. Y. Yamano, N. Takenouchi, H. C. Li, U. Tomaru, K. Yao, C. W. Grant, D. A. Maric and S. Jacobson: Virusinduced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease. J Clin Invest, 115 (5), 1361-8 (2005). (Pubitemid 40629056)
82. U. Oh, C. Grant, C. Griffith, K. Fugo, N. Takenouchi and S. Jacobson: Reduced Foxp3 protein expression is associated with inflammatory disease during human t lymphotropic virus type 1 Infection. J Infect Dis, 193 (11), 1557-66 (2006). (Pubitemid 43794586)
83. T. Kohno, Y. Yamada, N. Akamatsu, S. Kamihira, Y. Imaizumi, M. Tomonaga and T. Matsuyama: Possible origin of adult T-cell leukemia/lymphoma cells from human T lymphotropic virus type-1-infected regulatory T cells. Cancer Sci, 96 (8), 527-33 (2005). (Pubitemid 41387306)
84. G. Roncador, J. F. Garcia, L. Maestre, E. Lucas, J. Menarguez, K. Ohshima, S. Nakamura, A. H. Banham and M. A. Piris: FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma. Leukemia, 19 (12), 2247-53 (2005). (Pubitemid 41741621)
85. S. Chen, N. Ishii, S. Ine, S. Ikeda, T. Fujimura, L. C. Ndhlovu, P. Soroosh, K. Tada, H. Harigae, J. Kameoka, N. Kasai, T. Sasaki and K. Sugamura: Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells. Int Immunol, 18 (2), 269-77 (2006). (Pubitemid 43160140)
86. D. C. Macallan, D. Wallace, Y. Zhang, C. De Lara, A. T. Worth, H. Ghattas, G. E. Griffin, P. C. Beverley and D. F. Tough: Rapid turnover of effector-memory CD4 (+) T cells in healthy humans. J Exp Med, 200 (2), 255-60 (2004). (Pubitemid 38982184)
87. C. A. Michie, A. McLean, C. Alcock and P. C. Beverley: Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature, 360 (6401), 264-5 (1992).