FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma

Leukemia

Volumn 19, Issue 12, 2005, Pages 2247-2253

  Roncador, G ^a   Garcia, J F ^a   Maestre, L ^a   Lucas, E ^a   Menarguez, J ^b   Ohshima, K ^c   Nakamura, S ^d   Banham, A H ^e   Piris, M A ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^c FUKUOKA UNIVERSITY   (Japan)

^d AICHI CANCER CENTER HOSPITAL   (Japan)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Adult T cell leukaemia lymphoma; FOXP3; Lymphoma; Monoclonal antibody; Regulatory T cell

Indexed keywords

MONOCLONAL ANTIBODY; PARAFFIN; TRANSCRIPTION FACTOR FOXP3;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; T CELL LEUKEMIA; T CELL LYMPHOMA; TISSUE SECTION; TUMOR CELL;

EID: 28544443601     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2403965     Document Type: Article

References (27)

1. Fontenot JD, Rudensky AY. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 2005; 6: 331-337.
2. Kronenberg M, Rudensky A. Regulation of immunity by self-reactive T cells. Nature 2005; 435: 598-604.
3. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-1061.
4. Bennett CL, Ochs HD. IPEX is a unique X-linked syndrome characterized by immune dysfunction, polyendocrinopathy, enteropathy, and a variety of autoimmune phenomena. Curr Opin Pediatr 2001; 13: 533-538.
5. Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001; 27: 20-21.
6. Ochs HD, Ziegler SF, Torgerson TR. FOXP3 acts as a rheostat of the immune response. Immunol Rev 2005; 203: 156-164.
7. Godfrey VL, Wilkinson JE, Russell LB. X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am J Pathol 1991; 138: 1379-1387.
8. Roncador G, Brown P, Maestre L, Hue S, Martínez-Torrecuadrada J, Ling K et al. Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single cell level. Eur J Immunol 2005; 35: 1681-1691.
9. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 4: 330-336.
10. Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003; 4: 337-342.
11. Hori S, Sakaguchi S. Foxp3: A critical regulator of the development and function of regulatory T cells. Microbes Infect 2004; 6: 745-751.
12. Watanabe S. Adult T-cell leukemia/lymphoma. In: Knowles DM, (ed). Neoplastic Hematopathology, 2nd edn. Philadelphia, PA: Lippincott Williams & Wilkins, 2001, 1603-1616.
13. Shimoyama M. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-1987). Br J Haematol 1991; 79: 428-437.
14. Jaffe E, Harris N, Stein H, Vardiman J. Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2001.
15. Nicot C. Current views in HTLV-I-associated adult T-cell leukemia/ lymphoma. Am J Hematol 2005; 78: 232-239.
16. Uchiyama T, Hori T, Tsudo M, Wano Y, Umadome H, Tamori S et al. Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells. J Clin Invest 1985; 76: 446-453.
17. Karube K, Ohshima K, Tsuchiya T, Yamaguchi T, Kawano R, Suzumiya J et al. Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells. Br J Haematol 2004; 126: 81-84.
18. Ohshima K, Kikuchi M, Masuda Y, Kobari S, Sumiyoshi Y, Eguchi F et al. Defective provirus form of human T-cell leukemia virus type I in adult T-cell leukemia/lymphoma: Clinicopathological features. Cancer Res 1991; 51: 4639-4642.
19. Ohshima K, Yoshida T, Kikuchi M, Masuda Y, Kimura N, Satoh H. Rearrangement of human T cell receptor beta and gamma chain genes in adult T cell leukemia/lymphoma. Hematol Oncol 1990; 8: 111-118.
20. Martinez-Ramirez A, Cigudosa JC, Maestre L, Rodriguez-Perales S, Haralambieva E, Benitez J et al. Simultaneous detection of the immunophenotypic markers and genetic aberrations on routinely processed paraffin sections of lymphoma samples by means of the FICTION technique. Leukemia 2004; 18: 348-353.
21. Graca L. New tools to identify regulatory T cells. Eur J Immunol 2005; 35: 1678-1680.
22. Vieira PL, Christensen JR, Minaee S, O'Neill EJ, Barrat FJ, Boonstra A et al. IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells. J Immunol 2004; 172: 5986-5993.
23. Matsubara Y, Hori T, Morita R, Sakaguchi S, Uchiyama T. Phenotypic and functional relationship between adult T-cell leukemia cells and regulatory T cells. Leukemia 2005; 19: 482-483.
24. Moriyama K, Muranishi H, Nishimura J, Tanaka K, Asayama R, Takita A. Immunodeficiency in preclinical smoldering adult T-cell leukemia. Jpn J Clin Oncol 1988; 18: 363-369.
25. Read S, Powrie F. CD4(+) regulatory T cells. Curr Opin Immunol 2001; 13: 644-649.
26. Alvaro T, Lejeune M, Salvado MT, Bosch R, Garcia JF, Jaen J et al. Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells. Clin Cancer Res 2005; 11: 1467-1473.
27. Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004; 10: 942-949.