Regulation of epithelial junctions by proteins of the ADP-ribosylation factor family

Frontiers in Bioscience

Volumn 14, Issue 2, 2009, Pages 717-730

  Hiroi, Toyoko ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Actin cytoskeleton; ADP ribosylation factor; Beta1 integrin; Cell motility; E cadherin; Epithelial adherens

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR;

ANIMAL; EPITHELIUM CELL; HUMAN; PHYSIOLOGY; REVIEW; TIGHT JUNCTION;

ADP-RIBOSYLATION FACTORS; ANIMALS; EPITHELIAL CELLS; HUMANS; TIGHT JUNCTIONS;

EID: 63849164451     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3275     Document Type: Article

References (127)

1. Braga VM and Yap AS: The challenges of abundance: epithelial junctions and small GTPase signalling. Curr Opin Cell Biol 17(5), 466-474(2005) (Pubitemid 41267160)
2. Van Aelst L and Symons M: Role of Rho family GTPases in epithelial morphogenesis. Genes Dev 16(9), 1032-1054(2002) (Pubitemid 34507193)
3. Wennerberg K, Rossman KL and der CJ: The Ras superfamily at a glance. J Cell Sci 118(Pt 5), 843-846(2005) (Pubitemid 40484876)
4. Kahn RA and Gilman AG: Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin. J Biol Chem 259(10), 6228-6234(1984) (Pubitemid 14106335)
5. Kahn RA and Gilman AG: The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein. J Biol Chem 261(17), 7906-7911(1986) (Pubitemid 17208722)
6. D'Souza-Schorey C and Chavrier P: ARF proteins: roles in membrane traffic and beyond. Nat Rev Mol Cell Biol 7(5), 347-358(2006)
7. Donaldson JG, Honda A and Weigert R: Multiple activities for Arf1 at the Golgi complex. Biochim Biophys Acta 1744(3), 364-373(2005) (Pubitemid 40848254)
8. Donaldson JG: Multiple roles for Arf6: sorting, structuring, and signaling at the plasma membrane. J Biol Chem 278(43), 41573-41576(2003) (Pubitemid 37310409)
9. Jaworski J: ARF6 in the nervous system. Eur J Cell Biol 86(9), 513-524(2007) (Pubitemid 47233377)
10. Burd CG, Strochlic TI and Gangi Setty SR: Arf-like GTPases: not so Arf-like after all. Trends Cell Biol 14(12), 687-694(2004) (Pubitemid 39572554)
11. Gillingham AK and Munro S: The small G proteins of the Arf family and their regulators. Annu Rev Cell Dev Biol 23, 579-611(2007)
12. Kahn RA, Cherfils J, Elias M, Lovering RC, Munro S and Schurmann A: Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins. J Cell Biol 172(5), 645-650(2006)
13. Peyroche A, Antonny B, Robineau S, Acker J, Cherfils J and Jackson CL: Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain. Mol Cell 3(3), 275-285(1999) (Pubitemid 29290668)
14. Renault L, Guibert B and Cherfils J: Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor. Nature 426(6966), 525-530(2003) (Pubitemid 37522634)
15. *Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism. Mol Cell 12(6), 1403-1411(2003) (Pubitemid 38037010)
16. Casanova JE: Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors. Traffic 8(11), 1476-1485(2007) (Pubitemid 47578354)
17. Inoue H and Randazzo PA: Arf GAPs and their interacting proteins. Traffic 8(11), 1465-1475(2007) (Pubitemid 47591332)
18. Cukierman E, Huber I, Rotman M and Cassel D: The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization. Science 270(5244), 1999-2002(1995)
19. Huber I, Cukierman E, Rotman M, Aoe T, Hsu VW, Cassel D: Requirement for both the amino-terminal catalytic domain and a noncatalytic domain for in vivo activity of ADP-ribosylation factor GTPase-activating protein. J Biol Chem 273(38), 24786-24791(1998) (Pubitemid 28454982)
20. Balch WE, Kahn RA and Schwaninger R: ADP-ribosylation factor is required for vesicular trafficking between the endoplasmic reticulum and the cis-Golgi compartment. J Biol Chem 267(18), 13053-13061(1992)
21. Ooi CE, Dell'Angelica EC and Bonifacino JS: ADP-Ribosylation factor 1(ARF1) regulates recruitment of the AP-3 adaptor complex to membranes. J Cell Biol 142(2), 391-402(1998) (Pubitemid 28361547)
22. Altan-Bonnet N, Phair RD, Polishchuk RS, Weigert R and Lippincott-Schwartz J: A role for Arf1 in mitotic Golgi disassembly, chromosome segregation, and cytokinesis. Proc Natl Acad Sci U S A 100(23), 13314-13319(2003) (Pubitemid 37444739)
23. Dascher C and Balch WE: Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus. J Biol Chem 269(2), 1437-1448(1994) (Pubitemid 24032542)
24. Cao H, Weller S, Orth JD, Chen J, Huang B, Chen JL, Stamnes M and McNiven MA: Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. Nat Cell Biol 7(5), 483-492(2005) (Pubitemid 40637408)
25. Godi A, Pertile P, Meyers R, Marra P, Di Tullio G., Iurisci C, Luini A, Corda D and De Matteis MA: ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns (4, 5) P2 on the Golgi complex. Nat Cell Biol 1(5), 280-287(1999) (Pubitemid 129495778)
26. Haynes LP, Thomas GM and Burgoyne RD: Interaction of neuronal calcium sensor-1 and ADP-ribosylation factor 1 allows bidirectional control of phosphatidylinositol 4-kinase beta and trans-Golgi network-plasma membrane traffic. J Biol Chem 280(7), 6047-6054(2005) (Pubitemid 40280088)
27. D'Souza-Schorey C, Li G, Colombo MI and Stahl PD: A regulatory role for ARF6 in receptor-mediated endocytosis. Science 267(5201), 1175-1178(1995)
28. Altschuler Y, Liu S, Katz L, Tang K, Hardy S, Brodsky F, Apodaca G and Mostov K: ADP-ribosylation factor 6 and endocytosis at the apical surface of Madin-Darby canine kidney cells. J Cell Biol 147(1), 7-12(1999) (Pubitemid 30211791)
29. Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT and Lefkowitz RJ: beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. J Biol Chem 276(45), 42509-42513(2001)
30. Delaney KA, Murph MM, Brown LM and Radhakrishna H: Transfer of M2 muscarinic acetylcholine receptors to clathrin-derived early endosomes following clathrin-independent endocytosis. J Biol Chem 277(36), 33439-33446(2002) (Pubitemid 34984867)
31. Galas MC, Helms JB, Vitale N, Thiersé D, Aunis D and Bader MF: Regulated exocytosis in chromaffin cells. A potential role for a secretory granule-associated ARF6 protein. J Biol Chem 272(5), 2788-2793(1997) (Pubitemid 27053323)
32. Matsukawa J, Nakayama K, Nagao T, Ichijo H and Urushidani T: Role of ADP-ribosylation factor 6(ARF6) in gastric acid secretion. J Biol Chem 278(38), 36470-36475(2003) (Pubitemid 37139976)
33. Lawrence JT and Birnbaum MJ: ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4, 5-bisphosphate. Proc Natl Acad Sci U S A 100(23), 13320-13325(2003) (Pubitemid 37444740)
34. Zhang Q, Cox D, Tseng CC, Donaldson JG and Greenberg S.: A requirement for ARF6 in Fcgamma receptor-mediated phagocytosis in macrophages. J Biol Chem. 273(32), 19977-19981(1998) (Pubitemid 28377546)
35. Niedergang F, Colucci-Guyon E, Dubois T, Raposo G and Chavrier P.: ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages. J Cell Biol. 161(6), 1143-1150(2003) (Pubitemid 36870175)
36. Uchida H, Kondo A, Yoshimura Y, Mazaki Y and Sabe H: PAG3/Papalpha/ KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages. J Exp Med 193(8), 955-966(2001) (Pubitemid 32525868)
37. Palacios F, Price L, Schweitzer J, Collard JG and D'Souza-Schorey C: An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration. EMBO J 20(17), 4973-4986(2001) (Pubitemid 32848649)
38. Santy LC and Casanova JE: Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D. J Cell Biol 154(3), 599-610(2001) (Pubitemid 34286164)
39. Weber KS, Weber C, Ostermann G, Dierks H, Nagel W and Kolanus W: Cytohesin-1 is a dynamic regulator of distinct LFA-1 functions in leukocyte arrest and transmigration triggered by chemokines. Curr Biol 11(24), 1969-1974(2001) (Pubitemid 33146424)
40. Santy LC: Characterization of a fast cycling ADP-ribosylation factor 6 mutant. J Biol Chem 277(43), 40185-40188(2002) (Pubitemid 35215587)
41. Song J, Khachikian Z, Radhakrishna H and Donaldson JG: Localization of endogenous ARF6 to sites of cortical actin rearrangement and involvement of ARF6 in cell spreading. J Cell Sci 111(Pt 15), 2257-2267(1998) (Pubitemid 28403530)
42. Palacios F and D'Souza-Schorey C: Modulation of Rac1 and ARF6 activation during epithelial cell scattering. J Biol Chem 278(19), 17395-17400(2003) (Pubitemid 36799625)
43. Radhakrishna H, Al-Awar O, Khachikian Z and Donaldson JG: ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. J Cell Sci 112(Pt 6), 855-866(1999) (Pubitemid 29179318)
44. Boshans RL, Szanto S, van Aelst L and D'Souza-Schorey C: ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA. Mol Cell Biol 20(10), 3685-3694(2000) (Pubitemid 30243914)
45. D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD and Van Aelst L: A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements. EMBO J 16(17), 5445-5454(1997) (Pubitemid 27380151)
46. Radhakrishna H, Klausner RD and Donaldson JG: Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase. J Cell Biol 134(4), 935-947(1996) (Pubitemid 26278219)
47. Albertinazzi C, Za L, Paris S and de Curtis I: ADP-ribosylation factor 6 and a functional PIX-p95-APP1 complex are required for Rac1B-mediated neurite outgrowth. Mol Biol Cell 14(4), 1295-1307(2003) (Pubitemid 36547401)
48. Hernandez-Deviez DJ, Roth MG, Casanova JE and Wilson JM: ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate 5-kinase alpha. Mol Biol Cell 15(1), 111-120(2004) (Pubitemid 38044948)
49. Brown HA, Gutowski S, Moomaw CR, Slaughter C and Sternweis PC: ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity. Cell 75(6), 1137-1144(1993) (Pubitemid 24006110)
50. Honda A, Nogami M, Yokozeki T, Yamazaki M, Nakamura H, Watanabe H, Kawamoto K, Nakayama K, Morris AJ, Frohman MA and Kanaho Y: Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell 99(5), 521-532(1999)
51. Randazzo PA, Inoue H and Bharti S: Arf GAPs as regulators of the actin cytoskeleton. Biol Cell 99(10), 583-600(2007) (Pubitemid 47543316)
52. Shin K, Fogg VC and Margolis B: Tight junctions and cell polarity. Annu Rev Cell Dev Biol 22, 207-235(2006)
53. Luton F, Klein S, Chauvin JP, Le Bivic A, Bourgoin S, Franco M and Chardin P: EFA6, exchange factor for ARF6, regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement. Mol Biol Cell 15(3), 1134-1145(2004) (Pubitemid 38316222)
54. Shultz T, Nash-Livni N, Shmuel M and Altschuler Y: EFA6 regulates endosomal trafficking and affects early endosomes in polarized MDCK cells. Biochem Biophys Res Commun 351(1), 106-112(2006) (Pubitemid 44635413)
55. Franco M, Peters PJ, Boretto J, van Donselaar E, Neri A, D'Souza-Schorey C and Chavrier P: EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization. EMBO J 18(6), 1480-1491(1999) (Pubitemid 29127062)
56. Derrien V, Couillault C, Franco M, Martineau S, Montcourrier P, Houlgatte R and Chavrier P: A conserved C-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions. J Cell Sci 115(Pt 14), 2867-2879(2002)
57. Niessen CM: Tight junctions/adherens junctions: basic structure and function. J Invest Dermatol 127(11), 2525-2532(2007) (Pubitemid 47585053)
58. Bryant DM and Stow JL: The ins and outs of E-cadherin trafficking. Trends Cell Biol 14(8), 427-434(2004) (Pubitemid 39092700)
59. Palacios F, Schweitzer JK, Boshans RL and D'Souza-Schorey C: ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly. Nat Cell Biol 4(12), 929-936(2002) (Pubitemid 35469422)
60. Le TL, Yap AS and Stow JL: Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamics. J Cell Biol 146(1), 219-232(1999) (Pubitemid 29349976)
61. Paterson AD, Parton RG, Ferguson C, Stow JL and Yap AS: Characterization of E-cadherin endocytosis in isolated MCF-7 and chinese hamster ovary cells: the initial fate of unbound E-cadherin. J Biol Chem 278(23), 21050-21057(2003) (Pubitemid 36806416)
62. Akhtar N and Hotchin NA: RAC1 regulates adherens junctions through endocytosis of E-cadherin. Mol Biol Cell 12(4), 847-862(2001) (Pubitemid 33051983)
63. Yap AS: The morphogenetic role of cadherin cell adhesion molecules in human cancer: a thematic review. Cancer Invest 16(4), 252-261(1998) (Pubitemid 28211011)
64. Braga VM, Machesky LM, Hall A and Hotchin NA: The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J Cell Biol 137(6), 1421-1431(1997) (Pubitemid 27265952)
65. Hordijk PL, ten Klooster JP, van der Kammen RA, Michiels F, Oomen LC and Collard JG: Inhibition of invasion of epithelial cells by Tiam1-Rac signaling. Science 278(5342), 1464-1466(1997) (Pubitemid 27509819)
66. Noren NK, Niessen CM, Gumbiner BM and Burridge K: Cadherin engagement regulates Rho family GTPases. J Biol Chem 276(36), 33305-33308(2001)
67. Someya A, Sata M, Takeda K, Pacheco-Rodriguez G, Ferrans VJ, Moss J and Vaughan M: ARF-GEP (100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6. Proc Natl Acad Sci U S A 98(5), 2413-2418(2001) (Pubitemid 32209496)
68. Hiroi T, Someya A, Thompson W, Moss J and Vaughan M: GEP100/BRAG2: activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and alpha-catenin. Proc Natl Acad Sci U S A 103(28), 10672-10677(2006) (Pubitemid 44078035)
69. Morishige M, Hashimoto S, Ogawa E, Toda Y, Kotani H, Hirose M, Wei S, Hashimoto A, Yamada A, Yano H, Mazaki Y, Kodama H, Nio Y, Manabe T, Wada H, Kobayashi H and Sabe H: GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion. Nat Cell Biol 10(1), 85-92(2008)
70. Sheen VL, Ganesh VS, Topcu M, Sebire G, Bodell A, Hill RS, Grant PE, Shugart YY, Imitola J, Khoury SJ, Guerrini R and Walsh CA: Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex. Nat Genet 36(1), 69-76(2004) (Pubitemid 38056210)
71. Shin HW, Morinaga N, Noda M and Nakayama K: BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity. Mol Biol Cell 15(12), 5283-5294(2004) (Pubitemid 39564724)
72. Gates J and Peifer M: Can 1000 reviews be wrong? Actin, alpha-Catenin, and adherens junctions. Cell 123(5), 769-772(2005) (Pubitemid 41721025)
73. Yamada S, Pokutta S, Drees F, Weis WI and Nelson WJ: Deconstructing the cadherin-catenin-actin complex. Cell 123, 889-901(2005) (Pubitemid 41721034)
74. Drees F, Pokutta S, Yamada S, Nelson WJ and Weis WI: Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell 123, 903-915(2005) (Pubitemid 41721035)
75. Johnson RP and Craig SW: The carboxy-terminal tail domain of vinculin contains a cryptic binding site for acidic phospholipids. Biochem Biophys Res Commun 210(1), 159-164(1995)
76. Gilmore AP and Burridge K: Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate. Nature 381(6582), 531-535(1996) (Pubitemid 26170933)
77. Weekes J, Barry ST and Critchley DR: Acidic phospholipids inhibit the intramolecular association between the N-and C-terminal regions of vinculin, exposing actin-binding and protein kinase C phosphorylation sites. Biochem J 314(Pt 3), 827-832(1996) (Pubitemid 26097743)
78. Corgan AM, Singleton C, Santoso CB and Greenwood JA: Phosphoinositides differentially regulate alpha-actinin flexibility and function. Biochem J 378(Pt 3), 1067-1072(2004) (Pubitemid 38406887)
79. Fukami K, Furuhashi K, Inagaki M, Endo T, Hatano S and Takenawa T: Requirement of phosphatidylinositol 4, 5-bisphosphate for alpha-actinin function. Nature 359(6391), 150-152(1992)
80. Lee S, Park JB, Kim JH, Kim Y, Kim JH, Shin KJ, Lee JS, Ha SH, Suh PG and Ryu SH: Actin directly interacts with phospholipase D, inhibiting its activity. J Biol Chem 276(30), 28252-28260(2001)
81. Park JB, Kim JH, Kim Y, Ha SH, Yoo JS, Du G, Frohman MA, Suh PG and Ryu SH: Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner. J Biol Chem 275(28), 21295-21301(2000) (Pubitemid 30481827)
82. Norman JC, Jones D, Barry ST, Holt MR, Cockcroft S and Critchley DR: ARF1 mediates paxillin recruitment to focal adhesions and potentiates Rho-stimulated stress fiber formation in intact and permeabilized Swiss 3T3 fibroblasts. J Cell Biol 143(7), 1981-1995(1998) (Pubitemid 29022618)
83. Liu Y, Loijens JC, Martin KH, Karginov AV and Parsons JT: The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly. Mol Biol Cell 13(6), 2147-2156(2002) (Pubitemid 34651498)
84. Sakagami H, Honma T, Sukegawa J, Owada Y, Yanagisawa T and Kondo H: Somatodendritic localization of EFA6A, a guanine nucleotide exchange factor for ADP-ribosylation factor 6, and its possible interaction with alpha-actinin in dendritic spines. Eur J Neurosci 25(3), 618-628(2007)
85. Colley WC, Sung TC, Roll R, Jenco J, Hammond SM, Altshuller Y, Bar-Sagi D, Morris AJ and Frohman MA: Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr Biol 7(3), 191-201(1997) (Pubitemid 27164725)
86. Green KJ and Simpson CL: Desmosomes: new perspectives on a classic. J Invest Dermatol 127(11), 2499-2515(2007) (Pubitemid 47585074)
87. Naslavsky N, Weigert R and Donaldson JG: Convergence of non-clathrin-and clathrin-derived endosomes involves Arf6 inactivation and changes in phosphoinositides. Mol Biol Cell 14(2), 417-431(2003) (Pubitemid 36237006)
88. Radhakrishna H and Donaldson JG: ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway. J Cell Biol 139(1), 49-61(1997) (Pubitemid 27444080)
89. Mukherjee S, Gurevich VV, Jones JC, Casanova JE, Frank SR, Maizels ET, Bader MF, Kahn RA, Palczewski K, Aktories K and Hunzicker-Dunn M: The ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization. Proc Natl Acad Sci U S A 97(11), 5901-5906(2000) (Pubitemid 30367496)
90. Brown FD, Rozelle AL, Yin HL, Balla T and Donaldson JG: Phosphatidylinositol 4, 5-bisphosphate and Arf6-regulated membrane traffic. J Cell Biol 154(5), 1007-1017(2001) (Pubitemid 34286180)
91. Mitra SK, Hanson DA and Schlaepfer DD: Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 6(1), 56-68(2005) (Pubitemid 40064899)
92. Pellinen T and Ivaska J: Integrin traffic. J Cell Sci 119(Pt 18), 3723-3731(2006) (Pubitemid 44614425)
93. Powelka AM, Sun J, Li J, Gao M, Shaw LM, Sonnenberg A and Hsu VW: Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11. Traffic 5(1), 20-36(2004) (Pubitemid 38159401)
94. Dunphy JL, Moravec R, Ly K, Lasell TK, Melancon P and Casanova JE: The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins. Curr Biol 16(3), 315-320(2006) (Pubitemid 43190232)
95. Jackson TR, Brown FD, Nie Z, Miura K, Foroni L, Sun J, Hsu VW, Donaldson JG and Randazzo PA: ACAPs are arf6 GTPase-activating proteins that function in the cell periphery. J Cell Biol 151(3), 627-638(2000)
96. Li J, Peters PJ, Bai M, Dai J, Bos E, Kirchhausen T, Kandror KV and Hsu VW: An ACAP1-containing clathrin coat complex for endocytic recycling. J Cell Biol 178(3), 453-464(2007) (Pubitemid 47196153)
97. Dai J, Li J, Bos E, Porcionatto M, Premont RT, Bourgoin S, Peters PJ and Hsu VW: ACAP1 promotes endocytic recycling by recognizing recycling sorting signals. Dev Cell 7(5), 771-776(2004) (Pubitemid 39462697)
98. Li J, Ballif BA, Powelka AM, Dai J, Gygi SP and Hsu VW: Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration. Dev Cell 9(5), 663-673(2005) (Pubitemid 41555148)
99. Bellis SL: Variant glycosylation: an underappreciated regulatory mechanism for beta1 integrins. Biochim Biophys Acta 1663(1-2), 52-60(2004) (Pubitemid 38625579)
100. Shen X, Hong MS, Moss J and Vaughan M: BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin beta1. Proc Natl Acad Sci U S A 104(4), 1230-1235(2007) (Pubitemid 46183987)
101. Lu J, Tiao G, Folkerth R, Hecht J, Walsh C and Sheen V: Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia. J Comp Neurol 494(3), 476-484(2006) (Pubitemid 41790996)
102. Schaller MD: Paxillin: a focal adhesion-associated adaptor protein. Oncogene 20(44), 6459-6472(2001) (Pubitemid 32977851)
103. Turner CE: Paxillin and focal adhesion signalling. Nat Cell Biol 2(12), E231-236(2000)
104. 1*GTP/Arf GAP interface reveals an Arf1 mutant that selectively affects the Arf GAP ASAP1. Curr Biol 15(23), 2164-2169(2005) (Pubitemid 41739751)
105. Kondo A, Hashimoto S, Yano H, Nagayama K, Mazaki Y and Sabe H: A new paxillin-binding protein, PAG3/Papα/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration. Mol Biol Cell 11(4), 1315-1327(2000) (Pubitemid 30211032)
106. Yoon HY, Miura K, Cuthbert EJ, Davis KK, Ahvazi B, Casanova JE and Randazzo PA: ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPaseactivating-protein activity and binding to RhoA-GTP. J Cell Sci 119(Pt 22), 4650-4666(2006) (Pubitemid 44964262)
107. Liu Y, Yerushalmi GM, Grigera PR and Parsons JT: Mislocalization or reduced expression of Arf GTPaseactivating protein ASAP1 inhibits cell spreading and migration by influencing Arf1 GTPase cycling. J Biol Chem 280(10), 8884-8892(2005) (Pubitemid 40409578)
108. Furman C, Short SM, Subramanian RR, Zetter BR and Roberts TM: DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism. J Biol Chem 277(10), 7962-7969(2002) (Pubitemid 34968247)
109. Onodera Y, Hashimoto S, Hashimoto A, Morishige M, Mazaki Y, Yamada A, Ogawa E, Adachi M, Sakurai T, manabe T, Wasa H, Masura N and Sabe H: Expression of AMAP1, an Arf GAP, provides novel targets to inhibit breast cancer invasive activiteies. EMBO J 24(5), 963-973(2005) (Pubitemid 40470145)
110. Brown MT, Andrade J, Radhakrishna H, Donaldson JG, Cooper JA, Randazzo PA: ASAP1, a phospholipiddependent arf GTPase-activating protein that associates with and is phosphorylated by Src. Mol Cell Biol 18(12), 7038-7051(1998) (Pubitemid 28533024)
111. Zhao ZS, Manser E, Loo TH and Lim L: Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly. Mol Cell Biol 20(17), 6354-6363(2000) (Pubitemid 30650222)
112. Turner CE, Brown MC, Perrotta JA, Riedy MC, Nikolopoulos SN, McDonald AR, Bagrodia S, Thomas S and Leventhal PS: Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: a role in cytoskeletal remodeling. J Cell Biol 145(4), 851-863(1999) (Pubitemid 29240860)
113. Frank SR, Adelstein MR and Hansen SH: GIT2 represses Crk-and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover. EMBO J 25(9), 1848-1859(2006)
114. Nishiya N, Kiosses WB, Han J, Ginsberg MH: An alpha4 integrin-paxillin- Arf-GAP complex restricts Rac activation to the leading edge of migrating cells. Nat Cell Biol 7(4), 343-352(2005) (Pubitemid 40533123)
115. Turner CE, West KA and Brown MC: Paxillin-ARF GAP signaling and the cytoskeleton. Curr Opin Cell Biol 13(5), 593-599(2001) (Pubitemid 32817018)
116. de Curtis I: Cell migration: GAPs between membrane traffic and the cytoskeleton. EMBO Rep 2(4), 277-281(2001)
117. Kaverina I, Krylyshkina O and Small JV: Regulation of substrate adhesion dynamics during cell motility. Int J Biochem Cell Biol 34(7), 746-761(2002) (Pubitemid 34304165)
118. Ridley AJ: Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking. Trends Cell Biol 16(10), 522-529(2006) (Pubitemid 44444995)
119. Takaishi K, Sasaki T, Kotani H, Nishioka H and Takai Y: Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J Cell Biol 139(4), 1047-1059(1997) (Pubitemid 27508574)
120. Ménétrey J, Perderiset M, Cicolari J, Dubois T, Elkhatib N, El Khadali F, Franco M, Chavrier P and Houdusse A: Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. EMBO J 26(7), 1953-1962(2007) (Pubitemid 46624047)
121. Dubois T, Paléotti O, Mironov AA, Fraisier V, Stradal TE, De Matteis MA, Franco M and Chavrier P: Golgilocalized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics. Nat Cell Biol 7(4), 353-364(2005) (Pubitemid 40533124)
122. Fucini RV, Navarrete A, Vadakkan C, Lacomis L, Erdjument-Bromage H, Tempst P and Stamnes M: Activated ADP-ribosylation factor assembles distinct pools of actin on golgi membranes. J Biol Chem 275(25), 18824-18829(2000) (Pubitemid 30422844)
123. Fucini RV, Chen JL, Sharma C, Kessels MM and Stamnes M: Golgi vesicle proteins are linked to the assembly of an actin complex defined by mAbp1. Mol Biol Cell 13(2), 621-631(2002) (Pubitemid 34165088)
124. Mao YS and Yin HL: Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases. Pflugers Arch 455(1), 5-18(2007) (Pubitemid 47403983)
125. Yin HL and Janmey PA: Phosphoinositide regulation of the actin cytoskeleton. Annu Rev Physiol 65, 761-789(2003) (Pubitemid 38249176)
126. Thiery JP: Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15(6), 740-746(2003) (Pubitemid 37487967)
127. Styers ML, Kowalczyk AP and Faundez V: Architecture of the vimentin cytoskeleton is modified by perturbation of the GTPase ARF1. J Cell Sci 119(Pt 17), 3643-3654(2006) (Pubitemid 44501868)