The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of β1 integrins

Current Biology

Volumn 16, Issue 3, 2006, Pages 315-320

  Dunphy, Jillian L ^a   Moravec, Radim ^a   Ly, Kim ^a   Lasell, Troy K ^b   Melancon, Paul ^b   Casanova, James E ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 6; ADP-RIBOSYLATION FACTOR 6; BETA1 INTEGRIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; IQSEC1 PROTEIN, HUMAN; ISOPROTEIN; PRIMER DNA; SMALL INTERFERING RNA;

ARTICLE; CELL ADHESION; COMPARATIVE STUDY; ENDOCYTOSIS; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENETICS; HELA CELL; HUMAN; IMMUNOBLOTTING; IMMUNOPRECIPITATION; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT; RNA INTERFERENCE;

ADP-RIBOSYLATION FACTORS; ANTIGENS, CD29; CELL ADHESION; DNA PRIMERS; ENDOCYTOSIS; FLOW CYTOMETRY; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HELA CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MICROSCOPY, FLUORESCENCE; PROTEIN ISOFORMS; PROTEIN TRANSPORT; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 31944442964     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2005.12.032     Document Type: Article

References (25)

1. A.M. Powelka, J. Sun, J. Li, M. Gao, L.M. Shaw, A. Sonnenberg, and V.W. Hsu Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11 Traffic 5 2004 20 36
2. R. Cox, R.J. Mason-Gamer, C.L. Jackson, and N. Segev Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers Mol. Biol. Cell 15 2004 1487 1505
3. A. Someya, M. Sata, K. Takeda, G. Pacheco-Rodriguez, V.J. Ferrans, J. Moss, and M. Vaughan ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6 Proc. Natl. Acad. Sci. USA 98 2001 2413 2418
4. S.A. Beausoleil, M. Jedrychowski, D. Schwartz, J.E. Elias, J. Villen, J. Li, M.A. Cohn, L.C. Cantely, and S.P. Gygi Large-scale characterization of HeLa cell nuclear phosphoproteins Proc. Natl. Acad. Sci. USA 101 2004 12130 12135
5. L.C. Santy, and J.E. Casanova Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D J. Cell Biol. 154 2001 599 610
6. S.R. Frank, J.C. Hatfield, and J.E. Casanova Remodeling of the actin cytoskeleton is coordinately regulated by protein kinase C and the ADP-ribosylation factor nucleotide exchange factor ARNO Mol. Biol. Cell 9 1998 3133 3146
7. J. Song, Z. Khachikian, H. Radhakrishna, and J.G. Donaldson Localization of endogenous ARF6 to sites of cortical actin rearrangement and involvement of ARF6 in cell spreading J. Cell Sci. 111 1998 2257 2267
8. F. Palacios, L. Price, J. Schweitzer, J.G. Collard, and C. D'Souza-Schorey An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration EMBO J. 20 2001 4973 4986
9. H. Sabe Requirement for Arf6 in cell adhesion, migration, and cancer cell invasion J. Biochem. (Tokyo) 134 2003 485 489
10. F.D. Brown, A.L. Rozelle, H.L. Yin, T. Balla, and J.G. Donaldson Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic J. Cell Biol. 154 2001 1007 1017
11. K. Kawamoto, Y. Yoshida, H. Tamaki, S. Torii, C. Shinotsuka, S. Yamashina, and K. Nakayama GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat Traffic 3 2002 483 495
12. X. Zhao, T.K. Lasell, and P. Melancon Localization of large ADP-ribosylation factor-guanine nucleotide exchange factors to different Golgi compartments: evidence for distinct functions in protein traffic Mol. Biol. Cell 13 2002 119 133
13. C. Shinotsuka, S. Waguri, M. Wakasugi, Y. Uchiyama, and K. Nakayama Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins Biochem. Biophys. Res. Commun. 294 2002 254 260
14. C. Shinotsuka, Y. Yoshida, K. Kawamoto, H. Takatsu, and K. Nakayama Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation J. Biol. Chem. 277 2002 9468 9473
15. R. Yamaji, R. Adamik, K. Takeda, A. Togawa, G. Pacheco-Rodriguez, V.J. Ferrans, J. Moss, and M. Vaughan Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex Proc. Natl. Acad. Sci. USA 97 2000 2567 2572
16. R. Garcia-Mata, T. Szul, C. Alvarez, and E. Sztul ADP-ribosylation factor/COPI-dependent events at the endoplasmic reticulum-Golgi interface are regulated by the guanine nucleotide exchange factor GBF1 Mol. Biol. Cell 14 2003 2250 2261
17. L.M. Memmo, and P. McKeown-Longo The alphavbeta5 integrin functions as an endocytic receptor for vitronectin J. Cell Sci. 111 1998 425 433
18. G. Altankov, and F. Grinnell Fibronectin receptor internalization and AP-2 complex reorganization in potassium-depleted fibroblasts Exp. Cell Res. 216 1995 299 309
19. N.D. Boyd, B.M. Chan, and N.O. Petersen Beta1 integrins are distributed in adhesion structures with fibronectin and caveolin and in coated pits Biochem. Cell Biol. 81 2003 335 348
20. M. Krauss, M. Kinuta, M.R. Wenk, P. De Camilli, K. Takei, and V. Haucke ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma J. Cell Biol. 162 2003 113 124
21. D. Padron, Y.J. Wang, M. Yamamoto, H. Yin, and M.G. Roth Phosphatidylinositol phosphate 5-kinase Ibeta recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis J. Cell Biol. 162 2003 693 701
22. K.W. Wong, and R.R. Isberg Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake J. Exp. Med. 198 2003 603 614
23. S. Onel, L. Bolke, and C. Klambt The Drosophila ARF6-GEF Schizo controls commissure formation by regulating Slit Development 131 2004 2587 2594
24. H. Long, C. Sabatier, L. Ma, A. Plump, W. Yuan, D.M. Ornitz, A. Tamada, F. Murakami, C.S. Goodman, and M. Tessier-Lavigne Conserved roles for Slit and Robo proteins in midline commissural axon guidance Neuron 42 2004 213 223
25. S.H. Hansen, and J.E. Casanova Gs alpha stimulates transcytosis and apical secretion in MDCK cells through cAMP and protein kinase A J. Cell Biol. 126 1994 677 687