Monocarboxylate transporter 8 in neuronal cell growth

Endocrinology

Volumn 150, Issue 4, 2009, Pages 1961-1969

  James, S R ^a   Franklyn, J A ^a   Reaves, B J ^b   Smith, V E ^a   Chan, S Y ^a   Barrett, T G ^a   Kilby, M D ^a   McCabe, C J ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; LIOTHYRONINE; MONOCARBOXYLATE TRANSPORTER 8; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CELL FUNCTION; CELL GROWTH; CELL MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE SILENCING; HORMONE TRANSPORT; HUMAN; HUMAN CELL; IN VITRO STUDY; NERVE CELL; PRIORITY JOURNAL; WILD TYPE;

BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CASPASE 3; CASPASE 7; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CRYSTALLINS; ENDOPLASMIC RETICULUM; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC VECTORS; HUMANS; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE PROTEINS; NEURONS; RNA, SMALL INTERFERING; TRIIODOTHYRONINE;

EID: 63849158541     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-1031     Document Type: Article

References (56)

1. Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J, O'Heir CE, Mitchell ML, Hermos RJ, Waisbren SE, Faix JD, Klein RZ 1999 Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 341:549-555
2. Pop VJ, Kuijpens JL, van Baar AL, Verkerk G, van Son MM, de Vijlder JJ, Vulsma T, Wiersinga WM, Drexhage HA, Vader HL 1999 Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol (Oxf) 50:149-155
3. Chan S, Kilby MD 2000 Thyroid hormone and central nervous system development. J Endocrinol 165:1-8
4. Chan S, Kachilele S, Hobbs E, Bulmer JN, Boelaert K, McCabe CJ, Driver PM, Bradwell AR, Kester M, Visser TJ, Franklyn JA, Kilby MD 2003 Placental iodothyronine deiodinase expression in normal and growth-restricted human pregnancies. J Clin Endocrinol Metab 88:4488 -4495
5. Kilby MD 2003 Thyroid hormones and fetal brain development. Clin Endocrinol (Oxf) 59:280 -281
6. Pop VJ, Brouwers EP, Vader HL, Vulsma T, van Baar AL, de Vijlder JJ 2003 Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clin Endocrinol (Oxf) 59:282-288
7. Ekins R 1992 The free hormone hypothesis and measurement of free hormones. Clin Chem 38:1289 -1293
8. Hennemann G, Docter R, Friesema EC, de Jong M, Krenning EP, Visser TJ 2001 Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability. Endocr Rev 22:451-476
9. Abe T, Kakyo M, Sakagami H, Tokui T, Nishio T, Tanemoto M, Nomura H, Hebert SC, Matsuno S, Kondo H, Yawo H 1998 Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. J Biol Chem 273:22395-22401
10. Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ 2003 Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem 278:40128 -40135
11. Lafreniere RG, Carrel L, Willard HF 1994 Anovel transmembrane transporter encoded by the XPCT gene in Xq13.2. Hum Mol Genet 3:1133-1139
12. Heuer H, Maier MK, Iden S, Mittag J, Friesema EC, Visser TJ, Bauer K 2005 The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone-sensitive neuron populations. Endocrinology 146:1701-1706
13. Heuer H 2007 The importance of thyroid hormone transporters for brain development and function. Best Pract Res Clin Endocrinol Metab 21:265-276
14. Tu HM, Legradi G, Bartha T, Salvatore D, Lechan RM, Larsen PR 1999 Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone. Endocrinology 140:784-790
15. Dumitrescu AM, Liao XH, Best TB, Brockmann K, Refetoff S 2004 Anovel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. Am J Hum Genet 74:168 -175
16. Friesema EC, Grueters A, Biebermann H, Krude H, von Moers A, Reeser M, Barrett TG, Mancilla EE, Svensson J, Kester MH, Kuiper GG, Balkassmi S, Uitterlinden AG, Koehrle J, Rodien P, Halestrap AP, Visser TJ 2004 Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet 364:1435-1437
17. Biebermann H, Ambrugger P, Tarnow P, von Moers A, Schweizer U, Grueters A 2005 Extended clinical phenotype, endocrine investigations and functional studies of a loss-of-function mutation A150V in the thyroid hormone specific transporter MCT8. Eur J Endocrinol 153:359 -366
18. Brockmann K, Dumitrescu AM, Best TT, Hanefeld F, Refetoff S 2005 X-linked paroxysmal dyskinesia and severe global retardation caused by defective MCT8 gene. J Neurol 252:663-666
19. Holden KR, Zuniga OF, May MM, Su H, Molinero MR, Rogers RC, Schwartz CE 2005 X-linked MCT8 gene mutations: characterization of the pediatric neurologic phenotype. J Child Neurol 20:852-857
20. Jansen J, Friesema EC, Kester MH, Milici C, Reeser M, Gruters A, Barrett TG, Mancilla EE, Svensson J, Wemeau JL, Silva Canalli MH, Lundgren J, McEntagart ME, Hopper N, Arts WF, Visser TJ 2007 Functional analysis of MCT8 mutations identified in patients with X-linked psychomotor retardation and elevated serum triiodothyronine. JClin Endocrinol Metab 92:2378 -2381
21. Maranduba CM, Friesema EC, Kok F, Kester MH, Jansen J, Sertie AL, Passos- Bueno MR, Visser TJ 2006 Decreased cellular uptake and metabolism in Allan-Herndon-Dudley syndrome (AHDS) due to a novel mutation in the MCT8 thyroid hormone transporter. J Med Genet 43:457-460
22. Schwartz CE, May MM, Carpenter NJ, Rogers RC, Martin J, Bialer MG, Ward J, Sanabria J, Marsa S, Lewis JA, Echeverri R, Lubs HA, Voeller K, Simensen RJ, Stevenson RE 2005 Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene. Am J Hum Genet 77:41-53
23. Schwartz CE, Stevenson RE 2007 The MCT8 thyroid hormone transporter and Allan-Herndon-Dudley syndrome. Best Pract Res Clin Endocrinol Metab 21:307-321
24. 3 levels caused by mutations in monocarboxylate transporter 8. Nat Clin Pract Endocrinol Metab 2:512-523
25. Andrews PW 1984 Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev Biol 103:285-293
26. Chan S, McCabe CJ, Visser TJ, Franklyn JA, Kilby MD 2003 Thyroid hormone responsiveness in N-Tera-2 cells. J Endocrinol 178:159 -167
27. Chatterjee VK, Lee JK, Rentoumis A, Jameson JL 1989 Negative regulation of the thyroid-stimulating hormone alpha gene by thyroid hormone: receptor interaction adjacent to the TATA box. Proc Natl Acad Sci USA 86:9114 -9118
28. Lazar MA, Berrodin TJ 1990 Thyroid hormone receptors form distinct nuclear protein-dependent and independent complexes with a thyroid hormone response element. Mol Endocrinol 4:1627-1635
29. Ashizawa K, Cheng SY 1992 Regulation of thyroid hormone receptormediated transcription by a cytosol protein. Proc Natl Acad Sci USA 89: 9277-9281
30. Friesema EC, Kuiper GG, Jansen J, Visser TJ, Kester MH 2006 Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. Mol Endocrinol 20:2761-2772
31. Gittoes NJ, McCabe CJ, Verhaeg J, Sheppard MC, Franklyn JA 1997 Thyroid hormone and estrogen receptor expression in normal pituitary and nonfunctioning tumors of the anterior pituitary. J Clin Endocrinol Metab 82:1960 -1967
32. Heaney AP, Singson R, McCabe CJ, Nelson V, Nakashima M, Melmed S 2000 Expression of pituitary-tumour transforming gene in colorectal tumours. Lancet 355:716 -719
33. Boelaert K, Tannahill LA, Bulmer JN, Kachilele S, Chan SY, Kim D, Gittoes NJ, Franklyn JA, Kilby MD, McCabe CJ 2003 A potential role for PTTG/ securin in the developing human fetal brain. FASEB J 17:1631-1639
34. Schroder M, Kaufman RJ 2005 ER stress and the unfolded protein response. Mutat Res 569:29 -63
35. Kozutsumi Y, Segal M, Normington K, Gething MJ, Sambrook J 1988 The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature 332:462-464
36. Flynn GC, Pohl J, Flocco MT, Rothman JE 1991 Peptide-binding specificity of the molecular chaperone BiP. Nature 353:726 -730
37. Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D 2000 Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 6:1099 -1108
38. Okada T, Yoshida H, Akazawa R, Negishi M, Mori K 2002 Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. Biochem J 366:585-594
39. Ron D 2002 Translational control in the endoplasmic reticulum stress response. J Clin Invest 110:1383-1388
40. Sagara Y, Fernandez-Belda F, de Meis L, Inesi G 1992 Characterization of the inhibition of intracellular Ca2+ transport ATPases by thapsigargin. J Biol Chem 267:12606 -12613
41. Li WW, Alexandre S, Cao X, Lee AS 1993 Transactivation of the grp78 promoter by Ca2+ depletion. A comparative analysis with A23187 and the endoplasmic reticulum Ca(2 + )-ATPase inhibitor thapsigargin. J Biol Chem 268: 12003-12009
42. Manning Fox JE, Meredith D, Halestrap AP 2000 Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol 529(Pt 2):285-293
43. Mori J, Suzuki S, Kobayashi M, Inagaki T, Komatsu A, Takeda T, Miyamoto T, Ichikawa K, Hashizume K 2002 Nicotinamide adenine dinucleotide phosphate-dependent cytosolic T(3) binding protein as a regulator for T(3)-medi- ated transactivation. Endocrinology 143:1538 -1544
44. Suzuki S, Suzuki N, Mori J, Oshima A, Usami S, Hashizume K 2007 μ-Crys- tallin as an intracellular 3,5,3'-triiodothyronine holder in vivo. Mol Endocrinol 21:885-894
45. Visser WE, Friesema EC, Jansen J, Visser TJ 2007 Thyroid hormone transport by monocarboxylate transporters. Best Pract Res Clin Endocrinol Metab 21: 223-236
46. Hagenbuch B, Meier PJ 2004 Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch 447:653-665
47. James SR, Franklyn JA, Kilby MD 2007 Placental transport of thyroid hormone. Best Pract Res Clin Endocrinol Metab 21:253-264
48. Taylor PM, Ritchie JW 2007 Tissue uptake of thyroid hormone by amino acid transporters. Best Pract Res Clin Endocrinol Metab 21:237-251
49. Sugiura M, Nagaoka M, Yabuuchi H, Akaike T 2007 Overexpression of MCT8 enhances the differentiation of ES cells into neural progenitors. Bio- chem Biophys Res Commun 360:741-745
50. Jansen J, Friesema EC, Kester MH, Schwartz CE, Visser TJ 2008 Genotype- phenotype relationship in patients with mutations in thyroid hormone transporter MCT8. Endocrinology 149:2184 -2190
51. Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP 2005 Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). J Biol Chem 280:27213-27221
52. Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN, Halestrap AP 2000 CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J 19:3896 -3904
53. Halestrap AP, Meredith D 2004 The SLC16 gene family from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch 447:619 -628
54. Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, EndouH2002 Thehuman T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics 79: 95-103
55. Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H 2001 Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem 276:17221-17228
56. Friesema EC, Jansen J, Jachtenberg JW, Visser WE, Kester MH, Visser TJ 2008 Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10. Mol Endocrinol 22:1357-1369