Identification of human CYP2C8 as a retinoid-related orphan nuclear receptor target gene

Journal of Pharmacology and Experimental Therapeutics

Volumn 329, Issue 1, 2009, Pages 192-201

  Chen, Yuping ^a   Coulter, Sherry ^a   Jetten, Anton M ^a   Goldstein, Joyce A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; RETINOID RELATED ORPHAN NUCLEAR RECEPTOR ALPHA; RETINOID RELATED ORPHAN NUCLEAR RECEPTOR GAMMA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; GENE DELETION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIVER CELL; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA INTERFERENCE; TRANSCRIPTION REGULATION;

ADENOVIRIDAE; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; DNA, COMPLEMENTARY; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENETIC VECTORS; HEPATOCYTES; HUMANS; LIVER; PLASMIDS; PROMOTER REGIONS, GENETIC; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION;

EID: 63849084776     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.148916     Document Type: Article

References (33)

1. Albrecht U (2006) Orchestration of gene expression and physiology by the circadian clock. J Physiol Paris 100:243-251.
2. Besnard S, Heymes C, Merval R, Rodriguez M, Galizzi JP, Boutin JA, Mariani J, and Tedgui A (2002) Expression and regulation of the nuclear receptor RORalpha in human vascular cells. FEBS Lett 511:36-40.
3. Bort R, Gomez-Lechon MJ, Castell JV, and Jover R (2004) Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes. Arch Biochem Biophys 426:63-72.
4. Chauvet C, Bois-Joyeux B, and Danan JL (2002) Retinoic acid receptor-related orphan receptor (ROR) alpha4 is the predominant isoform of the nuclear receptor RORalpha in the liver and is up-regulated by hypoxia in HepG2 human hepatoma cells. Biochem J 364:449-456.
5. Chauvet C, Bois-Joyeux B, Fontaine C, Gervois P, Bernard MA, Staels B, and Danan JL (2005) The gene encoding fibrinogen-beta is a target for retinoic acid receptor-related orphan receptor alpha. Mol Endocrinol 19:2517-2526.
6. Chen Y, Ferguson SS, Negishi M, and Goldstein JA (2003) Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter. Mol Pharmacol 64:316-324.
7. Chen Y, Ferguson SS, Negishi M, and Goldstein JA (2004) Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol Exp Ther 308:495-501.
8. Chen Y, Kissling G, Negishi M, and Goldstein JA (2005) The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter. J Pharmacol Exp Ther 314:1125-1133.
9. Ferguson SS, Chen Y, LeCluyse EL, Negishi M, and Goldstein JA (2005) Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive an-drostane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha. Mol Pharmacol 68:747-757.
10. Genoux A, Dehondt H, Helleboid-Chapman A, Duhem C, Hum DW, Martin G, Pennacchio LA, Staels B, Fruchart-Najib J, and Fruchart JC (2005) Transcrip-tional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORalpha. Arterioscler Thromb Vasc Biol 25:1186-1192.
11. Gerbal-Chaloin S, Daujat M, Pascussi JM, Pichard-Garcia L, Vilarem MJ, and Maurel P (2002) Transcriptional regulation ofCYP2C9 gene: role ofglucocorticoid receptor and constitutive androstane receptor. J Biol Chem 277:209-217.
12. Goldstein JA (2001) Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. Br J Clin Pharmacol 52:349 - 355.
13. Handschin C and Meyer UA(2003) Induction ofdrug metabolism:the role ofnuclear receptors. Pharmacol Rev 55:649 - 673.
14. Hastings M, O'Neill JS, and Maywood ES (2007) Circadian clocks: regulators of endocrine and metabolic rhythms. J Endocrinol 195:187-198.
15. Jetten AM and Joo JH (2006) Retinoid-related Orphan Receptors (RORs): Roles in Cellular Differentiation and Development. Adv Dev Biol 16:313-355.
16. Jover R, Bort R, Gomez-Lechon MJ, and Castell JV (1998) Re-expression of C/EBP alpha induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells. FEBS Le 431:227-230.
17. Jover R, Bort R, Gomez-Lechon MJ, and Castell JV (2001) Cytochrome P450 reg lation by hepatocyte nuclear factor 4 in human hepatocytes: a study using aden virus-mediated antisense targeting. Hepatology 33:668-675.
18. Kallen J, Schlaeppi JM, Bitsch F, Delhon I, and Fournier B (2004) Crystal structu of the human RORalpha Ligand binding domain in complex with cholester sulfate at 2.2 A. JBiol Chem 279:14033-14038.
19. Kallen JA, Schlaeppi JM, Bitsch F, Geisse S, Geiser M, Delhon I, and Fournier (2002) X-ray structure ofthe hRORalpha LBD at 1.63 A:structural and function data that cholesterol or a cholesterol derivative is the natural ligand of RORalph Structure 10:1697-1707.
20. Kang HS, Angers M, Beak JY, Wu X, Gimble JM, Wada T, Xie W, Collins JB Grissom SF, and Jetten AM (2007) Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism. Physiol Genomics 31:281-294.
21. Klose TS, Blaisdell JA, and Goldstein JA (1999) Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. J Biochem Mol Toxicol 13:289-295.
22. Komoroski BJ, Zhang S, Cai H, Hutzler JM, Frye R, Tracy TS, Strom SC, Lehmar T, Ang CY, Cui YY, et al. (2004) Induction and inhibition ofcytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures. Drug Metab Dispos 32:512-518.
23. Madan A, Graham RA, Carroll KM, Mudra DR, Burton LA, Krueger LA, Downey A Czerwinski M, Forster J, Ribadeneira MD, et al. (2003) Effects of prototypic microsomal enzyme inducers on cytochrome P450 expression in cultured huma hepatocytes. Drug Metab Dispos 31:421-431.
24. McFayden MC, Melvin WT, and Murray GI (1998) Regional distribution of indiviual forms of cytochrome P450 mRNA in normal adult human brain. Biochem Pharmacol 55:825-830.
25. Medvedev A, Yan ZH, Hirose T, Giguere V, and Jetten AM (1996) Cloning of a cDN encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element. Gene 181:199 - 206.
26. Ohdo S (2007) Chronopharmacology focused on biological clock. Drug Metab Pha macokinet 22:3-14.
27. Raucy JL, Mueller L, Duan K, Allen SW, Strom S, and Lasker JM (2002) Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocyte J Pharmacol Exp Ther 302:475-482.
28. Stehlin-Gaon C, Willmann D, Zeyer D, Sanglier S, Van Dorsselaer A, Renaud J Moras D, and Schüle R (2003) All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. Nat Struct Biol 10:820 - 825.
29. Totah RA and Rettie AE (2005) Cytochrome P450 2C8: substrates, inhibitors, phar macogenetics, and clinical relevance. Clin Pharmacol Ther 77:341-352.
30. Wada T, Kang HS, Angers M, Gong H, Bhatia S, Khadem S, Ren S, Ellis E, Strom SC, Jetten AM, et al. (2008) Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol Pharmacol 73:891-899.
31. Wray J and Bishop-Bailey D (2008) Epoxygenases and peroxisome proliferator activated receptors in mammalian vascular biology. Exp Physiol 93:148-154.
32. Yang X, Downes M, Yu RT, Bookout AL, He W, Straume M, Mangelsdorf DJ, and Evans RM (2006) Nuclear receptor expression links the circadian clock to metab olism. Cell 126:801-810.
33. Zeldin DC (2001) Epoxygenase pathways of arachidonic acid metabolism. J Biol Chem 276:36059 - 36062.