The gene encoding fibrinogen-β is a target for retinoic acid receptor-related orphan receptor α

Molecular Endocrinology

Volumn 19, Issue 10, 2005, Pages 2517-2526

  Chauvet, Caroline ^a   Bois Joyeux, Brigitte ^a   Fontaine, Coralie ^b   Gervois, Philippe ^b   Bernard, Marguerite Anne ^c   Staels, Bart ^b   Danan, Jean Louis ^a  

^a CNRS   (France)

^b INSERM   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; FIBRINOGEN; FIBRINOGEN BETA; MESSENGER RNA; RETINOIC ACID RECEPTOR RELATED ORPHAN RECEPTOR ALPHA; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR RISK; CELL STRAIN HEPG2; CHROMATIN; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; FEMALE; FIBRINOGEN BLOOD LEVEL; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC STABILITY; GENETIC TRANSFECTION; HEPATOMA CELL; HOMOZYGOSITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIVER; LIVER LEVEL; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN TARGETING; RECEPTOR BINDING; REGULATORY MECHANISM; TRANSCRIPTION INITIATION;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; DNA; FIBRINOGEN; GENES, REPORTER; HUMANS; LIVER; MICE; MICE, INBRED C57BL; MICE, NEUROLOGIC MUTANTS; PROMOTER REGIONS (GENETICS); RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSFECTION;

ATAXIA;

EID: 25444484668     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2005-0153     Document Type: Article

References (58)

1. Nuclear Receptors Nomenclature Committee 1999 A unified nomenclature system for the nuclear receptor superfamily. Cell 97:161-163
2. Giguère V 1999 Orphan nuclear receptors: from gene to function. Endocr Rev 20:689-725
3. Carlberg C, Hooft van Huijsduijnen R, Staple JK, DeLamarter JF, Becker-André M 1994 RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers. Mol Endocrinol 8:757-770
4. Giguère V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G 1994 Isoform-specific amino-terminal domains dictate DNA-binding properties of RORα, a novel family of orphan hormone nuclear receptors. Genes Dev 8:538-553
5. Giguère V, McBroom LD, Flock G 1995 Determinants of target gene specificity for RORα1: monomeric DNA binding by an orphan nuclear receptor. Mol Cell Biol 15:2517-2526
6. Harding HP, Atkins GB, Jaffe AB, Seo WJ, Lazar MA 1997 Transcriptional activation and repression by RORα, an orphan nuclear receptor required for cerebellar development. Mol Endocrinol 11:1737-1746
7. Raspé E, Mautino G, Duval C, Fontaine C, Duez H, Barbier O, Monte D, Fruchart J, Fruchart J-C, Staels B 2002 Transcriptional regulation of human Rev-erbα gene expression by the orphan nuclear receptor retinoic acid-related orphan receptor α. J Biol Chem 277:49275-49281
8. Gawlas K, Stunnenberg HG 2000 Differential binding and transcriptional behaviour of two highly related orphan receptors, RORα4 and RORβ1. Biochim Biophys Acta 1494:236-241
9. Becker-André M, André E, DeLamarter JF 1993 Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences. Biochem Biophys Res Commun 194:1371-1379
10. Hamilton BA, Frankel WN, Kerrebrock AW, Hawkins TL, Fitzhugh W, Kusumi K, Russell LB, Mueller KL, van Berkel V, Birren BW, Kruglyak L, Lander ES 1996 Disruption of the nuclear hormone receptor RORα in staggerer mice. Nature 379:736-739
11. Matysiak-Scholze U, Nehls M 1997 The structural integrity of RORα isoforms is mutated in staggerer mice: cerebellar coexpression of RORα1 and RORα4. Genomics 43:78-84
12. Herrup K, Mullen RJ 1979 Regional variation and absence of large neurons in the cerebellum of the staggerer mouse. Brain Res 172:1-12
13. Kopmels B, Mariani J, Delhaye-Bouchaud N, Audibert F, Fradelizi D, Wollman EE 1992 Evidence for a hyperexcitability state of staggerer mutant mice macrophages. J Neurochem 58:192-199
14. Delerive P, Monté D, Dubois G, Trottein F, Fruchart-Najib J, Mariani J, Fruchart J-C, Staels B 2001 The orphan nuclear receptor RORα is a negative regulator of the inflammatory response. EMBO Rep 2:42-48
15. Mamontova A, Seguret-Mace S, Esposito B, Chaniale C, Bouly M, Delhaye-Bouchaud N, Luc G, Staels B, Duverger N, Mariani J, Tedgui A 1998 Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORα. Circulation 98:2738-2743
16. Vu-Dac N, Gervois P, Grotzinger T, De Vos P, Schoonjans K, Fruchart JC, Auwerx J, Mariani J, Tedgui A, Staels B 1997 Transcriptional regulation of apolipoprotein A-I gene expression by the nuclear receptor RORα. J Biol Chem 272:22401-22404
17. Besnard S, Silvestre J-S, Duriez M, Bakouche J, Lemaigre-Dubreuil Y, Mariani J, Levy BI, Tedgui A 2001 Increased ischemia-induced angiogenesis in the staggerer mouse, a mutant on the nuclear receptor RORα. Circ Res 89:1209-1215
18. Matsui T 1997 Transcriptional regulation of a Purkinje cell-specific gene through a functional interaction between RORα and RAR. Genes Cells 2:263-272
19. Gold DA, Baek SH, Schork NJ, Rose DW, Larsen DD, Sachs B, Rosenfeld MG, Hamilton BA 2003 RORα coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron 40:1119-1131
20. Dussault I, Giguère V 1997 Differential regulation of the N-myc proto-oncogene by RORα and RVR, two orphan members of the superfamily of nuclear hormone receptors. Mol Cell Biol 17:1860-1867
21. Meyer T, Kneissel M, Mariani J, Fournier B 2000 In vitro and in vivo evidence for orphan nuclear receptor RORα function in bone metabolism. Proc Natl Acad Sci USA 97:9197-9202
22. Bois-Joyeux B, Chauvet C, Nacer-Chérif H, Bergeret W, Mazure N, Giguère V, Laudet V, Danan J-L 2000 Modulation of the far upstream enhancer of the rat α-fetoprotein gene by members of the RORα, Rev-erbα, and Rev-erbβ groups of monomeric orphan nuclear receptors. DNA Cell Biol 19:589-599
23. Raspé E, Duez H, Gervois P, Fiévet C, Fruchart J-C, Besnard S, Mariani J, Tedgui A, Staels B 2001 Transcriptional regulation of apolipoprotein C-III gene expression by the orphan receptor RORα. J Biol Chem 276:2865-2871
24. Chauvet C, Bois-Joyeux B, Danan J-L 2002 Retinoic acid receptor-related orphan receptor (ROR) α4 is the predominant isoform of the nuclear receptor RORα in liver and is up regulated by hypoxia in HepG2 human hepatoma cells. Biochem J 364:449-456
25. Kant JA, Fornace AJJ, Saxe D, Simon MI, McBride OW, Crabtree GR 1985 Evolution and organization of the fibrinogen locus on chromosome 4: gene duplication accompanied by transposition and inversion. Proc Natl Acad Sci USA 82:2344-2348
26. Mouse Genome Sequencing Consortium 2002 Initial sequencing and comparative analysis of the mouse genome. Nature 420:520-562
27. Marino MW, Fuller GM, Elder FF 1986 Chromosomal localization of human and rat A α, B β, and γ fibrinogen genes by in situ hybridization. Cytogenet Cell Genet 42:36-41
28. Anderson GM, Shaw AR, Shafer JA 1993 Functional characterization of promoter elements involved in regulation of human Bβ-fibrinogen expression. J Biol Chem 268:22650-22655
29. Dalmon J, Laurent M, Courtois G 1993 The human β fibrinogen promoter contains a hepatocyte nuclear factor 1-dependent interleukin-6-responsive element. Mol Cell Biol 13:1183-1193
30. Hu C-H, Harris JE, Davie EW, Chung DW 1995 Characterization of the 5′-flanking region of the gene for the α chain of human fibrinogen. J Biol Chem 270:28342-28349
31. Huber P, Laurent M, Dalmon J 1990 Human β-fibrinogen gene expression. J Biol Chem 265:5695-5701
32. Liu Z, Fuller GM 1995 Detection of a novel transcription factor for the Aα fibrinogen gene in response to interleukin 6. J Biol Chem 270:7580-7586
33. Mizuguchi J, Hu C-H, Cao Z, Loeb KR, Chung DW, Davie EW 1995 Characterization of the 5′-flanking region of the gene for the γ chain of human fibrinogen. J Biol Chem 270:28350-28356
34. Zhang Z, Fuentes NL, Fuller GM 1995 Characterization of the IL-6 responsive elements in the γ fibrinogen gene promoter. J Biol Chem 270:24287-24291
35. Yu S, Sher B, Kudryk B, Redman CM 1983 Intracellular assembly of human fibrinogen. J Biol Chem 258:13407-13410
36. Roy SN, Mukhopadhyay G, Redman CM 1990 Regulation of fibrinogen assembly: transfection of HepG2 cells with Bβ cDNA specifically enhances synthesis of the three component chains of fibrinogen. J Biol Chem 265:6389-6393
37. Koenig W 2003 Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost 89:601-609
38. Sirtori CR, Colli S 1993 Influences of lipid-modifying agents on hemostasis. Cardiovasc Drugs Ther 7:817-823
39. Kockx M, Gervois PP, Poulain P, Derudas B, Peters JM, Gonzalez FJ, Princen HMG, Kooistra T, Staels B 1999 Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-α. Blood 93:2991-2998
40. Gervois P, Vu-Dac N, Kleeman R, Kockx M, Dubois G, Laine B, Kosykh V, Fruchart J-C, Kooistra T, Staels B 2001 Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor α agonists via inhibition of CCAAT box/enhancer-binding protein β. J Biol Chem 276:33471-33477
41. Tronche F, Ringeisen F, Blumenfeld M, Yaniv M, Pontoglio M 1997 Analysis of the distribution of binding sites for a tissue-specific transcription factor in the vertebrate genome. J Mol Biol 266:231-245
42. Costa RH, Kalinichenko VV, Holterman A-XL, Wang X 2003 Transcription factors in liver development, differentiation, and regeneration. Hepatology 38:1331-1347
43. Courtois G, Baumhueter S, Crabtree GR 1988 Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters. Proc Natl Acad Sci USA 85:7937-7941
44. Wang GL, Semenza GL 1993 Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem 268:21513-21518
45. Marinkovic S, Jahreis GP, Wong GG, Baumann H 1989 IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo. J Immunol 142:808-812
46. Harding HP, Lazar MA 1993 The orphan receptor Rev-erbAα activates transcription via a novel response element. Mol Cell Biol 13:3113-3121
47. Harding HP, Lazar MA 1995 The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat. Mol Cell Biol 15:4791-4802
48. Retnakaran R, Flock G, Giguère V 1994 Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator. Mol Endocrinol 8:1234-1244
49. Forman BM, Chen J, Blumberg B, Kliewer SA, Henshaw R, Ong ES, Evans RM 1994 Cross-talk among RORα1 and the Rev-erb family of orphan nuclear receptors. Mol Endocrinol 8:1253-1261
50. Sakao E, Ishihara A, Horikawa K, Akiyama M, Arai M, Kato M, Seki N, Fukunaga K, Shimizu-Yabe A, Iwase K, Ohtsuka S, Sato T, Kohno Y, Shibata S, Takiguchi M 2003 Two-peaked synchronization in day/night expression rhythms of the fibrinogen gene cluster in the mouse liver. J Biol Chem 278:30450-30457
51. Ueda HR, Chen W, Adachi A, Wakamatsu H, Hayashi S, Takasugi T, Nagano M, Nakahama K-I, Suzuki Y, Sugano S, Lino M, Shigeyoshi Y, Hashimoto S 2002 A transcription factor response element for gene expression during circadian night. Nature 418:534-539
52. Djian P, Easley K, Green H 2000 Targeted ablation of the murine involucrin gene. J Cell Biol 151:381-387
53. Raspé E, Madsen L, Lefebvre A-M, Leitersdorf I, Gelman L, Peinado-Onsurbe J, Dallongeville J, Fruchart J-C, Berge R, Staels B 1999 Modulation of rat liver apolipoprotein gene expression and serum lipid levels by tetradecylthioacetic acid (TTA) via PPARα activation. J Lipid Res 40:2099-2110
54. Bois-Joyeux B, Denissenko M, Thomassin H, Guesdon S, Ikonomova R, Bernuau D, Feldmann G, Danan J-L 1995 The c-jun proto-oncogene down-regulates the rat α-fetoprotein promoter in HepG2 hepatoma cells without binding to DNA. J Biol Chem 270:10204-10211
55. sg) is gender-related. J Comp Neurol 411:267-273
56. Jelic-Ivanovic Z, Pevcevic N 1990 Fibrinogen determination by five methods in patients receiving streptokinase therapy. Clin Chem 36:698-699
57. Shang Y, Hu X, DiRenzo J, Lazar MA, Brown M 2000 Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103: 843-852
58. Giraud S, Bienvenu F, Avril S, Gascan H, Heery DM, Coqueret O 2002 Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1α. J Biol Chem 277:8004-8011