Use of thin film freezing to enable drug delivery: A review

Journal of Drug Delivery Science and Technology

Volumn 19, Issue 2, 2009, Pages 89-98

  Overhoff, Kirk A ^a   Johnston, K P ^b   Tam, J ^b   Engstrom, J ^c   Williams III, R O ^d  

^a VERTEX PHARMACEUTICALS   (United States)

^b The University of Texas at Austin   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Drug development; Modeling; Nanoparticle; Rapid freecing; Solidification

Indexed keywords

DANAZOL; DIAZEPAM; DOXORUBICIN; EUDRAGIT; HYDROXYPROPYLMETHYLCELLULOSE PHTHALATE; ITRACONAZOLE; NANOPARTICLE; POLYMER; TACROLIMUS;

AREA UNDER THE CURVE; CRYSTAL STRUCTURE; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG MANUFACTURE; DRUG MECHANISM; FILM; FREEZE DRYING; FREEZING; HEAT TRANSFER; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MORPHOLOGY; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRECIPITATION; REVIEW; SINGLE DRUG DOSE; SPRAY DRYING; SUPERCRITICAL FLUID; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 63749095789     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(09)50016-0     Document Type: Review

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