Stable amorphous danazol nanostructured powders with rapid dissolution rates produced by spray freezing into liquid

Drug Development and Industrial Pharmacy

Volumn 30, Issue 7, 2004, Pages 695-704

  Hu, Jiahui ^a,b   Johnston, Keith P ^c   Williams III, Robert O ^b  

^a FOREST RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c The University of Texas at Austin   (United States)

Author keywords

Amorphous; Dissolution; Glass transition temperature; Poorly water soluble drug; Spray freezing into liquid; Stability

Indexed keywords

DANAZOL; DESSICANT; EXCIPIENT; MACROGOL 8000; NANOPARTICLE; POLOXAMER; POLYMER; POVIDONE; PVP K 15; UNCLASSIFIED DRUG; WATER;

AEROSOL; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG PACKAGING; DRUG POTENCY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; FREEZING; GLASS TRANSITION TEMPERATURE; MODULATED DIFFERENTIAL SCANNING CALORIMETRY; MOISTURE; MORPHOLOGY; PARTICLE SIZE; PARTICLE SIZE DISTRIBUTION; PHYSICAL CHEMISTRY; POWDER; SCANNING ELECTRON MICROSCOPY; SPRAY FREEZING INTO LIQUID; SURFACE AREA ANALYSIS; SURFACE PROPERTY; THERMOGRAVIMETRY; WETTABILITY; X RAY DIFFRACTION;

DANAZOL; DRUG STABILITY; ESTROGEN ANTAGONISTS; PARTICLE SIZE; POWDERS; TECHNOLOGY, PHARMACEUTICAL;

EID: 4344689255     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120039212     Document Type: Article

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