Physical stability of micronized powders produced by spray-freezing into liquid (SFL) to enhance the dissolution of an insoluble drug

Pharmaceutical Development and Technology

Volumn 8, Issue 2, 2003, Pages 187-197

  Rogers, True L ^a,c   Johnston, Keith P ^b   Williams III, Robert O ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b The University of Texas at Austin   (United States)

^c DOW CHEMICAL COMPANY   (United States)

Author keywords

Danazol; Dissolution enhancement; Micronization; Particle engineering; Spray freezing into liquid; Stability

Indexed keywords

DANAZOL; POLOXAMER; POLYVINYL ALCOHOL; POVIDONE;

ANALYSIS OF VARIANCE; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; FREEZING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMIDITY; HYDROPHILICITY; MOISTURE; POROSITY; POWDER; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SPRAY FREEZING INTO LIQUID; SURFACE PROPERTY; TEMPERATURE; X RAY POWDER DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG COMPOUNDING; DRUG STABILITY; EXCIPIENTS; FREEZING; HUMIDITY; POWDERS; SOLUBILITY; SOLUTIONS; TEMPERATURE; X-RAY DIFFRACTION;

EID: 0037654793     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-120018489     Document Type: Article

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