Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 9, 2003, Pages 5016-5021

  Root, Michael J ^a   Hamer, Dean H ^b,c  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HELIX PROTEIN; ANTIVIRUS AGENT; CHIMERIC PROTEIN; GLYCOPROTEIN GP 41; INHIBITOR PROTEIN; NEUTRALIZING ANTIBODY; PSEUDOMONAS EXOTOXIN; UNCLASSIFIED DRUG; VIRUS FUSION PROTEIN; VIRUS GLYCOPROTEIN; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL KILLING; CONFORMATIONAL TRANSITION; CROSS REACTION; CYTOTOXICITY; DRUG TARGETING; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MEMBRANE FUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; BINDING SITES; CELL LINE; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP41; HIV-1; HUMANS;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; PSEUDOMONAS; PSEUDOMONAS EXOTOXIN;

EID: 0037966960     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0936926100     Document Type: Article

References (35)

1. Moore, J. P. & Stevenson, M. (2000) Nat. Rev. Mol. Cell Biol. 1, 40-49.
2. Wyatt, R. & Sodroski, J. (1998) Science 280, 1884-1888.
3. Freed, E. O. & Martin, M. A. (2001) in Field's Virology, ed. Howley, P. M. (Lippincott, Philadelphia), pp. 1971-2041.
4. Biscone, M., Pierson, T. & Doms, R. (2002) Curr. Opin. Pharmacol. 2, 529.
5. Burton, D. R. (1997) Proc. Natl. Acad. Sci. USA 94, 10018-10023.
6. Hanna, S. L., Yang, C., Owen, S. M. & Lal, R. B. (2002) AIDS 16, 1603-1608.
7. Chan, D. C., Chutkowski, C. T. & Kim, P. S. (1998) Proc. Natl. Acad. Sci. USA 95, 15613-15617.
8. Tan, K., Liu, J., Wang, J., Shen, S. & Lu, M. (1997) Proc. Natl. Acad. Sci. USA 94, 12303-12308.
9. Weissenhorn, W., Dessen, A., Harrison, S. C., Skehel, J. J. & Wiley, D. C. (1997) Nature 387, 426-430.
10. Eckert, D. M. & Kim, P. S. (2001) Annu. Rev. Biochem. 70, 777-810.
11. Furuta, R. A., Wild, C. T., Weng, Y. & Weiss, C. D. (1998) Nat. Struct. Biol. 5, 276-279.
12. Melikyan, G. B., Markosyan, R. M., Hemmati, H., Delmedico, M. K., Lambert, D. M. & Cohen, F. S. (2000) J. Cell Biol. 151, 413-423.
13. Wild, C. T., Shugars, D. C., Greenwell, T. K., McDanal, C. B. & Matthews, T. J. (1994) Proc. Natl. Acad. Sci. USA 91, 9770-9774.
14. Jiang, S., Lin, K., Strick, N. & Neurath, A. R. (1993) Nature 365, 113.
15. Kilby, J. M., Hopkins, S., Venetta, T. M., DiMassimo, B., Cloud, G. A., Lee, J. Y., Alldredge, L., Hunter, E., Lambert, D., Bolognesi, D., et al. (1998) Nat. Med. 4, 1302-1307.
16. Root, M. J., Kay, M. S. & Kim, P. S. (2001) Science 291, 884-888.
17. Eckert, D. M. & Kim, P. S. (2001) Proc. Natl. Acad. Sci. USA 98, 11187-11192.
18. Louis, J. M., Bewley, C. A. & Clore, G. M. (2001) J. Biol. Chem. 276, 29485-29489.
19. Rowell, J. F., Stanhope, P. E. & Siliciano, R. F. (1995) J. Immunol. 155, 473-488.
20. Ohno, H., Aguilar, R. C., Fournier, M. C., Hennecke, S., Cosson, P. & Bonifacino, J. S. (1997) Virology 238, 305-315.
21. Reiter, Y. & Pastan, I. (1996) Clin. Cancer Res. 2, 245-252.
22. Newton, D. L., Nicholls, P. J., Rybak, S. M. & Youle, R. J. (1994) J. Biol. Chem. 269, 26739-26745.
23. McHugh, L., Hu, S., Lee, B. K., Santora, K., Kennedy, P. E., Berger, E. A., Pastan, I. & Hamer, D. H. (2002) J. Biol. Chem. 277, 34383-34390.
24. Pitts, T. W., Bohanon, M. J., Leach, M. F., McQuade, T. J. Marschke, C. K., Merritt, J. A., Wierenga, W. & Nicholas, J. A. (1991) AIDS Res. Hum. Retroviruses 7, 741-750.
25. Connor, R. I., Chen, B. K., Choe, S. & Landau, N. R. (1995) Virology 206, 935-944.
26. Weng, Y. & Weiss, C. D. (1998) J. Virol. 72, 9676-9682.
27. Bera, T. K., Kennedy, P. E., Berger, E. A., Barbas, C. F., III, & Pastan, I. (1998) Mol. Med. 4, 384-391.
28. Ashorn, P., Berger, E. A. & Moss, B. (1993) Methods Enzymol. 221, 12-18.
29. Koshiba, T. & Chan, D. C. (2003) J. Biol. Chem. 278, 7573-7579.
30. Jiang, S., Lin, K. & Lu, M. (1998) J. Virol. 72, 10213-10217.
31. Sattentau, Q. J., Zolla-Pazner, S. & Poignard, P. (1995) Virology 206, 713-717.
32. Kliger, Y., Peisajovich, S. G., Blumenthal, R. & Shai, Y. (2000) J. Mol. Biol. 301, 905-914.
33. Ramachandran, R. V., Katzenstein, D. A., Wood, R., Batts, D. H. & Merigan, T. C. (1994) J. Infect. Dis. 170, 1009-1013.
34. Davey, R. T., Jr., Boenning, C. M., Herpin, B. R., Batts, D. H., Metcalf, J. A., Wathen, L., Cox, S. R., Polis, M. A., Kovacs, J. A., Falloon, J., et al. (1994) J. Infect. Dis. 170, 1180-1188.
35. Berger, E. A., Moss, B. & Pastan, I. (1998) Proc. Natl. Acad. Sci. USA 95, 11511-11513.