Liquiritigenin, a licorice flavonoid, helps mice resist disseminated candidiasis due to Candida albicans by Th1 immune response, whereas liquiritin, its glycoside form, does not

International Immunopharmacology

Volumn 9, Issue 5, 2009, Pages 632-638

  Lee, Ju Young ^a   Lee, Jue Hee ^a   Park, Ji Hye ^a   Kim, Song Yi ^a   Choi, Ji Young ^b   Lee, Seung Ho ^b   Kim, Yeong Shik ^c   Kang, Sam Sik ^c   Jang, Eui Chan ^d   Han, Yongmoon ^a  

^a Dongduk Women's University   (South Korea)

^b Yeungnam University   (South Korea)

^c Seoul National University   (South Korea)

^d Chung Ang University   (South Korea)

Author keywords

Anti CD4+; Anti IFN ; Candida albicans; Disseminated candidiasis; Liquiritigenin; Liquiritin; Th1 immune response

Indexed keywords

CD4 ANTIBODY; CD4 ANTIGEN; FLAVONOID; FLUCONAZOLE; GAMMA INTERFERON; INTERFERON RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; LIQUIRITIGENIN; LIQUIRITIN; ANTIINFECTIVE AGENT; BLOCKING ANTIBODY; CYTOKINE; FLAVANONE DERIVATIVE; GLUCOSIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLYCYRRHIZA; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; INVASIVE CANDIDIASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL TIME; TH1 CELL; TH2 CELL; TREATMENT RESPONSE; YEAST CELL; ADOPTIVE TRANSFER; ANIMAL; BACTERIAL COUNT; BAGG ALBINO MOUSE; CANDIDIASIS; CELLULAR IMMUNITY; DRUG EFFECTS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PATHOLOGY; PHYTOTHERAPY; PLANT ROOT; SECRETION (PROCESS);

ADOPTIVE TRANSFER; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIBODIES, BLOCKING; CANDIDA ALBICANS; CANDIDIASIS; COLONY COUNT, MICROBIAL; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLAVANONES; GLUCOSIDES; GLYCYRRHIZA; IMMUNITY, CELLULAR; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; PHYTOTHERAPY; PLANT ROOTS; TH1 CELLS;

EID: 63649105581     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.02.007     Document Type: Article

References (40)

1. Edwards J.E. Invasive Candida infections: evolution of a fungal pathogen. N Engl J Med 324 (1991) 1060-1062
2. Body G.P. The emergence of fungi as major hospital pathogens. J Hosp Infect 11 Suppl A (1988) 411-426
3. Han Y., and Cutler J.E. Antibody response that protects against disseminated candidasis. Infect Immun 63 (1995) 2714-2719
4. Han Y., Granger B., and Cutler J.E. Immunoprotection against candidiasis. In: Calderone R.A. (Ed). Candida and candidosis (2003), ASM Press, Washington DC 243-256
5. Roeder A., Kirschning C.J., Reupec R.A., Schaller M., and Korting H.C. Toll-like receptors and innate antifungal responses. Trends Microbiol 12 (2004) 44-49 [Review]
6. Romani L., and Howard D.H. Mechanisms of resistance to fungal infections. Curr Opin Immunol 7 (1995) 517-523
7. Puccetti P., Romani L., and Bistoni F. A Th1-Th2-like switch in candidiasis: new prospectives for therapy. Trends Microbiol 3 (1995) 237-240
8. Lavigne L.M., Schopf L.R., Chung C.L., Maylor R., and Sypek J.P. The role of recombinant murine IL-12 and INF-g in the pathogenesis of murine systemic Candida albicans infection. J Immunol 160 (1998) 284-292
9. Mossman T.R., and Coffman R.l. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7 (1989) 145-161
10. Fidel Jr. P.L. Distinct protective host defenses against oral and vaginal candidiasis. Med Mycol 40 (2002) 359-375
11. Maia D.C., Sassa M.F., Placeres M.C., and Carlos I.Z. Influence of Th1/Th2 cytokines and nitric oxide in murine systemic infection induced by Sporothrix schenckii. Mycopathologia 161 (2006) 11-19
12. Herzyk D.J., Gore E.R., Polsky R., Nadwodny K.L., Maier C.C., Liu S., et al. Immunomodulatory effects of anti-CD4 antibody in host resistance against infections and tumors in human CD4 transgenic mice. Infect Immun 69 (2001) 1032-1043
13. Lee J.H., and Han Y. Ginsenoside Rg1 helps mice resist to disseminated candidiasis by Th1 type differentiation of CD4+ T cell. Int Immunopharm 6 (2006) 1424-1430
14. Lee J., Lee J., Park J., Jung H., Kim J., Kang S., et al. Immunoregulatory activity by daucosterol, a β-sitosterol glycoside, induces protective Th1 immune response against disseminated candidiasis in mice. Vaccine 25 (2007) 3834-3840
15. Fu B., Li H., Wang X., Lee F., and Cui S. Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase. J Agric Food Chem 53 (2005) 7408-7414
16. Tsukamoto S., Aburatani M., Yoshida T., Yamashita Y., El-Beih A., and Ohta T. CYP3A4 inhibitors isolated from licorice. Biol Pharm Bull 28 (2005) 2000-2002
17. Hatano T., Yasuhara T., Myamoto K., and Okuda T. Anti-human immunodeficiency virus phenolics from licorice. Chem Pharm Bull 36 (1988) 2286-2288
18. Hatano T., Yasuhara T., Fukuda T., Noro T., and Okuda T. Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarylcoumarin and glisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase. Chem Pharm Bull 37 (1989) 3005-3009
19. Liu Z., Tanaka S., Horigome H., Hirano T., and Oka K. Induction of apoptosis in human lung fibroblasts and peripheral lymphocytes in vitro by Shosaiko-to derived phenolic metabolites. Biol Pharm Bull 25 (2002) 37-41
20. Kitagawa I., Chen W.Z., Taniyama T., Harada E., Hori K., Kobayashi M., et al. Quantitative determination of constituents in various licorice roots by means of high performance liquid chromatography. Yakugaku Zasshi 118 (1998) 519-528
21. Zuo F., Zhou M.Z., Yan M.Z., Liu M.L., Xiong Y.L., Zhang Q., et al. Metabolism of constituents in Huangqin-Tang, a prescription in traditional Chinese medicine, by human intestinal flora. Biol Pharm Bull 25 (2002) 558-563
22. Taniguchi C., Homma M., Takano O., Hirano T., Oka K., Aoyagi Y., et al. Pharmacological effects of urinary products obtained after treatment with Saiboku-To, a herbal medicine for bronchial asthma, on type IV allergic reaction. Planta Med 66 (2000) 607-611
23. Nakajima R., Sakakibara I., Kubo M., Higuchi M., Sasaki H., Okada M., et al. Proceedings of the 48th annual meeting of the Japanese Society of Pharmacognosy Kanazawa abstract papers (2001) 144
24. Ohtake N., Suzuki R., Daikuhara H., Nakai Y., Yamamoto M., Amagaya S., et al. Modulation of lung local immune responses by oral administration of a herbal medicine Sho-saiko-to. Int J Immunopharmacol 22 (2000) 419-430
25. Han Y., Riesselman M.H., and Cutler J.E. Protection against candidiasis by an immunoglobulin G3 (IgG3) monoclonal antibody specific for the same mannotriose as an IgM protective antibody. Infect Immun 68 (2000) 1649-1654
26. Han Y., and Lee J.H. Berberine synergy with amphotericin B against disseminated candidiasis in mice. Biol Pharm Bull 28 (2005) 541-544
27. Han Y. Ginkgo terpene component has an anti-inflammatory effect on Candida albicans-caused arthritis. Int Immunopharmacol 5 (2005) 1049-1056
28. Wang C.L., Zhang R.Y., Han Y.S., Dong X.G., and Liu W.B. Chemical studies of coumarins from Glycyrrhiza uralensis Fisch. Yao Xue Xue Bao 26 (1991) 147-151
29. Nakanishi T., Inada A., Kambayashi K., and Yoneda K. Flavonoid glycosides of the roots of Glycyrrhiza uralensis. Phytochemistry 24 (1985) 339-341
30. Han Y. Synergic effect of grape seed extract with amphotericin B against disseminated candidiasis due to Candidal albicans. Phytomedicine 14 (2007) 733-738
31. Louria D.B., Brayton R.G., and Finkel G. Studies on the pathogenesis of experimental Candida albicans infections in mice. Sabouraudia 268 (1963) 271-283
32. Sieck T., Moors M.A., Buckley H.R., and Blank K.J. Protection against murine disseminated candidiasis mediated by a Candida albicans-specific T-cell line. Infect Immun 61 (1993) 3540-3543
33. Sarkar K., and Das P.K. Protective effect of neoglycoprotein-conjugated muramyl peptide against Leishmania donovani infection: the role of cytokines. J Immunol 158 (1997) 5357-5365
34. Cantorna M.T., and Balish E. Role of CD4+ lymphocytes in resistance to mucosal candidiasis. Infect Immun 59 (1991) 2447-2455
35. Myers L., and Boulic P.J.D. Flow cytometric analysis of the TH1-TH2 shift in allergic individuals using Moducare™ (sterols/sterolins). 26th annual congress of the Physiology Society of Southern Africa (1998)
36. Lee Y.S., Han O.K., Park C.W., Suh S.I., Shin S.W., Yong C.H., et al. Immunomodulatory effects of aqueous-extracted Astragali Radix in methotrexate-treated mouse spleen cells. J Ethnopharmacol 84 (2003) 193-198
37. Jin R., and Kurashige S. Effects of Chinese herbs on macrophage function in N-buthyl-N-butanolnitrosoamine treated mice. Immunopharmacol Immunotoxicol 18 (1996) 105-114
38. Asano T., Ishihara K., Morota T., Takeda S., and Aburada M. Permeability of the flavonoids liquiritigenin and its glycosides in licorice roots and davidigenin, a hydrogenated metabolite of liquiritigenin, using human intestinal cell line Caco-2. J Ethnopharmacol 89 (2003) 285-289
39. Munder M., Mallo M., Eichmann K., and Modolell. Murine macrophage secrete interferone g upon combined stimulation with interleukin (IL)-12 and IL-18: a novel pathway of autocrine macrophage activation. J Exp Med 187 (1998) 2103-2108
40. Ogmundscottir H.G., and Weir D.M. Mechanisms of macrophage activation. Clin Exp Immunol 40 (1980) 223-234 [Review]