Ginsenoside Rg1 helps mice resist to disseminated candidiasis by Th1 type differentiation of CD4+ T cell

International Immunopharmacology

Volumn 6, Issue 9, 2006, Pages 1424-1430

  Lee, Jue Hee ^a   Han, Yongmoon ^a  

^a Dongduk Women's University   (South Korea)

Author keywords

Anti IFN antibody; Candida albicans; Candidal CFU; Disseminated candidiasis; Ginsenoside Rg1; Th1 lineage development

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GINSENOSIDE RG 1; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

AGAR GEL DIFFUSION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CD4+ T LYMPHOCYTE; CELL ISOLATION; CELL LINEAGE; CELLULAR IMMUNITY; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG MECHANISM; DRUG SENSITIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FUNGUS GROWTH; GROWTH INHIBITION; HOST RESISTANCE; IMMUNOMODULATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROVOCATION TEST; TH1 CELL; YEAST CELL;

ANIMALS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CANDIDIASIS; CELL DIFFERENTIATION; FEMALE; GINSENOSIDES; IMMUNITY, INNATE; IMMUNITY, NATURAL; MICE; MICE, INBRED BALB C; TH1 CELLS;

EID: 33745869802     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2006.04.009     Document Type: Article

References (31)

1. Attele A.S., Wu J.I., and Yuan C. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 58 (1999) 1685-1693
2. Lee F.C. Facts about ginseng, the elixir of life (1982), Hollyn International Corp, Elizabeth, NJ
3. Gillis N.C. Panax ginseng pharmacology: a nitric oxide link?. Biochem Pharmacol 54 (1997) 1-8
4. Sonnenborn U., and Proppert Y. Ginseng (Panax ginseng C.A. Meyer). Br J Phytother 2 (1991) 3-14
5. Huang K.C. The pharmacology of Chinese herbs (1999), CRC Press, Boca Raton. FL
6. Benishin C.G., Lee R., Wang L.C., and Liu H.J. Effects of ginsenoside Rb1 on central cholinergic metabolism. Pharmacology 42 (1991) 223-229
7. Yamaguchi Y., Haruta K., and Kobayashi H. Effects of ginsenosides on impaired on performance induced in the rat by scopolamine in a radial-arm maze. Psychoneuroendocrinology 20 (1995) 645-653
8. Tsang D., Yeung H.W., Tso W.W., and Peck H. Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes. Planta Med 3 (1985) 221-224
9. Benishin C.G. Actions of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings. Neurochem Int 21 (1992) 1-5
10. Kenaroba B., Neychev H., Hadjiivanova C., and Petkov V.D. Immunomodulating activity of ginsenoside Rg1 from Panax ginseng. Jpn J Pharmacol 54 (1990) 447-454
11. Lee E.J., Ko E., Lee J., Rho S., Ko S., Shin M.K., et al. Ginsenoside Rg1 enhances CD4(+) T-cell activities and modulates Th1/Th2 differentiation. Int Immunopharmacol 4 (2004) 235-244
12. Han Y., and Cutler J.E. Antibody response that protects against disseminated candidasis. Infect Immun 63 (1995) 2714-2719
13. Han Y., Kozel T.R., Zhang M.X., MacGill R.S., Carroll M.C., and Cutler J.E. Complement is essential for protection by an IgM and an IgG3 monoclonal antibody against experimental, hematogenously disseminated candidiasis. J Immunol 167 (2001) 1550-1557
14. Han Y. A role of neutrophil in anti-Candida monoclonal antibody protection against vaginal infection due to Candida albicans. Yakhak Hoeji 47 (2003) 190-194
15. Han Y., Granger B., and Cutler J.E. Immunoprotection against candidiasis. In: Candida and candidosis. In: Calderone R.A. (Ed) (2003), ASM Press, Washington DC 243-256
16. Edwards J.E. Invasive Candida infections: evolution of a fungal pathogen. N Engl J Med 324 (1991) 1060-1062
17. Body G.P. The emergence of fungi as major hospital pathogens. J Hosp Infect 11 Suppl A (1988) 411-426
18. Roeder A., Kirschning C.J., Reupec R.A., Schaller M., and Korting H.C. Toll-like receptors and innate antifungal responses. Trends Microbiol. 12 (2004) 44-49 [Review]
19. Romani L., and Howard D.H. Mechanisms of resistance to fungal infections. Curr Opin Immunol 7 (1995) 517-523
20. Puccetti P., Romani L., and Bistoni F. A Th1-Th2-like switch in candidiasis: new prospectives for therapy. Trends Microbiol 3 (1995) 237-240
21. Lavigne L.M., Schopf L.R., Chung C.L., Maylor R., and Sypek J.P. The role of recombinant murine IL-12 and INF-g in the pathogenesis of murine systemic Candida albicans infection. J Immunol 160 (1998) 284-292
22. Herzyk D.J., Gore E.R., Polsky R., Nadwodny K.L., Maier C.C., and Liu S. Immunomodulatory effects of anti-CD4 antibody in host resistance against infections and tumors in human CD4 transgenic mice. Infect Immun 69 (2001) 1032-1043
23. Han Y., Jin B.S., Ko S.K., and Lee J.H. Immunoactivity of ginsenosides Re and Rg1 that enhances resistance of mice against experimental disseminated candidiasis. Nat Prod Sci 10 (2004) 134-139
24. Han Y., and Lee J.H. Berberine synergy with amphotericin B against disseminated candidiasis in mice. Bio Pharm Bull 28 (2005) 541-544
25. Han Y. Ginkgo terpene component has an anti-inflammatory effect on Candida albicans-caused arthritis. Int Immunopharmacol 5 (2005) 1049-1056
26. Han Y. Utilization of ferroproteins by Candida albicans during candidastasis by apotransferrin. Arch Pharm Res 28 (2005) 963-969
27. Han Y., Riesselman M.H., and Cutler J.E. Protection against candidiasis by an immunoglobulin G3 (IgG3) monoclonal antibody specific for the same mannotriose as an IgM protective antibody. Infect Immun 68 (2000) 1649-1654
28. Louria D.B., Brayton R.G., and Finkel G. Studies on the pathogenesis of experimental Candida albicans infections in mice. Sabouraudia 268 (1963) 271-283
29. Sieck T., Moors M.A., Buckley H.R., and Blank K.J. Protection against murine disseminated candidiasis mediated by a Candida albicans-specific T-cell line. Infect Immun 61 (1993) 3540-3543
30. Cantorna M.T., and Balish E. Role of CD4+ lymphocytes in resistance to mucosal candidiasis. Infect Immun 59 (1991) 2447-2455
31. Tonnetti L., Spaccapelo R., Cenci E., Mencacci A., Puccetti P., Coffman R., et al. Interleukin-4 and-10 exacerbate candidiasis in mice. Eur J Immunol 25 (1995) 1559-1565