Immunomodulatory effects of anti-CD4 antibody in host resistance against infections and tumors in human CD4 transgenic mice

Infection and Immunity

Volumn 69, Issue 2, 2001, Pages 1032-1043

  Herzyk, D J ^a   Gore, E R ^a   Polsky, R ^a   Nadwodny, K L ^a   Maier, C C ^a   Liu, S ^a   Hart, T K ^a   Harmsen, A G ^a   Bugelski, P J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CORTICOSTEROID; CYTOKINE; GANGLIOSIDE ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 4; KELIXIMAB;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CANDIDA ALBICANS; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; FEMALE; HOST RESISTANCE; IMMUNOMODULATION; INFECTION RESISTANCE; MALE; MELANOMA; METASTASIS; MOUSE; NONHUMAN; PNEUMOCYSTIS CARINII; PRIORITY JOURNAL; SURVIVAL; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; CANDIDIASIS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MALE; MELANOMA, EXPERIMENTAL; MICE; MICE, TRANSGENIC; PNEUMOCYSTIS INFECTIONS; T-LYMPHOCYTES;

EID: 0035144136     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.2.1032-1043.2001     Document Type: Article

References (54)

1. A Primatized MAb to human CD4 causes receptor modulation, without marked reduction in CD4+ T cells in chimpanzees: In vitro and in vivo characterization of a MAb (IDEC-CE9.1) to human CD4
2. Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo
3. Susceptibility of beige mutam mice to candidiasis may be linked to a defect in granulocyte production by bone marrow stem cells
4. Strain dependence of antibody-mediated protection in murine systemic candidiasis
5. Production and function of cytokines in natural and acquired immunity to Candida albicans infection
6. Identification of a CD4 binding site on the beta 2 domain of HLA-DR molecules
7. Induction of immune tolerance during administration of monoclonal antibody to L3T4 does not depend on depletion of L3T4+ cells
8. Role of L3T4+ lymphocytes in protective immunity to systemic Candida albicans infection in mice
9. Interaction between CD4 and class II MHC molecules mediates cell adhesion
10. Anti-beta 1 integrin IgG inhibits pulmonary macrometastasis and the size of micrometastases from a murine mammary carcinoma
11. Administration of monoclonal anti-IFN-γ antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major
12. Cell adhesion and experimental metastasis: A study using the B16 malignant melanoma model system
13. Circulating CD4 and CD8 T cells have little impact on host defense against experimental vaginal candidiasis
14. IFN-γ and IL-4 pattern lymphokine secretion in mice partially depleted of CD4+ T cells by anti-CD4 monoclonal antibody
15. An enzyme-linked immunosorbent assay for quantifying adherence of Candida to human vascular endothelium
16. Age influences recovery of systemic and mucosal immune responses following acute depletion of CD4 T cells
17. A novel method for real time quantitative RT-PCR
18. In vivo inhibition by a monoclonal antibody to CD4+ T cells of humoral and cellular immunity in sheep
19. Anti-CD4 therapy in recent-onset NIDDM
20. Requirement for CD4+ cells in resistance to Pneumocystis carinii pneumonia in mice
21. Active immunity to Pneumocystis carinii reinfection in T-cell-depleted mice
22. Real time quantitative PCR
23. Reciprocal expression of interferon-γ or interleukin-4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets
24. Single-organism model of host defense against infection: A novel immunotoxicologic approach to evaluate immunomodulatory drugs
25. Suppression of the humoral response to anti-CD3 mAB by pretreatment with anti-CD4 mAB
26. Treatment of rheumatoid arthritis with an anti-CD4 monoclonal antibody
27. Humanized monoclonal antibody therapy for rheumatoid arthritis
28. Suppression of the immune response to immunotoxins with anti-CD4 monoclonal antibodies
29. Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4
30. Immunologic regulation of experimental cutaneous leishmaniasis. V. Characterization of effector and specific suppressor T cells
31. Specific suppression of responses to Leishmania tropica by a clonal T cell line
32. Phase 1 clinical trial of chimeric monoclonal anti-CD4 antibody in multiple sclerosis
33. Immunocytokines: A promising approach to cancer immunotherapy
34. Innate and acquired immune responses against Candida albicans in congenic B10.D2 mice with deficiency of C5 complement component
35. Efficacy of tumor-infiltrating lymphocytes in the treatment of hepatic metastases arising from transgenic intraocular tumors in mice
36. Role of natural killer and T-cells in interferon induced inhibition of spontaneous metastasis of B16F10I, murine melanoma
37. Treatment of a newly established transgenic model of chronic arthritis with nondepleting anti-CD4 monoclonal antibody
38. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
39. Control of immune-mediated diseases of the central nervous system with monoclonal (CD4-specific) antibodies
40. The pathoge, nesis of acute systemic candidiasis in a susceptible inbred mouse strain
41. Inhibition of contact sensitivity in human CD4+ transgenic mice by human CD4-specific monoclonal antibodies: CD4+ T-cell depletion is not required
42. Elimination of CD4+ T cells in mice bearing an advanced sarcoma augments the anti-tumor action of interleukin-2
43. Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN-gamma secreting TH1 cells in humans
44. Th1 and Th2 cytokine secretion patterns in murine candidiasis: Association of Th1 responses with acquired resistance
45. Course of primary candidiasis in T celldepleted mice infected with attenuated variant cells
46. Cellular and humoral immunity to Leishmania major in genetically susceptible mice after in vivo depletion of L3T4+ T cells
47. CD4+ helper T cells are required for resistance to a highly metastatic murine tumor
48. Comparative pharmacodynamics of keliximab and clenoliximab in transgenic mice bearing human CD4
49. A new model of Pneumocystis carinii infection in mice selectively depleted of helper T lymphocytes
50. Tumor necrosis factor and interleukin-6 in Candida albicans infection in normal and granulocytopenic mice
51. Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker
52. Interleukin-12 gene transfer results in CD8-dependent regression of murine CT26 liver tumors
53. Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia
54. Clinical and immunologic effects of a PRIMATIZED anti-CD4 monoclonal antibody in active rheumatoid arthritis: Results of a phase I, single dose escalating trial