Immunomodulatory effects of aqueous-extracted Astragali radix in methotrexate-treated mouse spleen cells

Journal of Ethnopharmacology

Volumn 84, Issue 2-3, 2003, Pages 193-198

  Lee, Young Sun ^a   Han, Ok Kyung ^a   Park, Chan Woo ^b   Suh, Seong Il ^c   Shin, Sang Woo ^a   Yang, Chae Ha ^a   Jeon, Tae Won ^a   Lee, Eun Sil ^a   Kim, Kwang Joong ^a   Kim, Seong Ho ^d   Yoo, Wang Keun ^a   Kim, Hyo Jung ^a  

^a Kyungsan University   (South Korea)

^b Kyungju Oriental Hospital   (South Korea)

^c Keimyung University   (South Korea)

^d Hanyang University   (South Korea)

Author keywords

Astragali radix; Cell proliferation; Cytokine; Methotrexate; RT PCR

Indexed keywords

ASTRAGALUS MEMBRANACEUS EXTRACT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; METHOTREXATE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG SYNTHESIS; FEMALE; IC 50; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; MITOGENESIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BODY WEIGHT; CELL DIVISION; CELL SEPARATION; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FABACEAE; FEMALE; GENE EXPRESSION REGULATION; IMMUNOSUPPRESSIVE AGENTS; METHOTREXATE; MICE; MICE, INBRED ICR; MITOGENS; OLIGONUCLEOTIDE PROBES; ORGAN SIZE; PLANT EXTRACTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SPLEEN;

EID: 0037297474     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(02)00298-2     Document Type: Article

References (26)

1. Hertog M.G., Feskens E.J., Hollman P.C., Katan M.B., Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet. 342:1993;1007-1011.
2. Hollman P.C., Katan M.B. Dietary flavonoids: intake, health effects and bioavailability. Food and Chemical Toxicology. 37:1999;937-942.
3. Hong C.Y., Ku J., Wu P. Astragalus membranaceus stimulates human sperm motility in vitro. American Journal of Chinese Medicine. 20:1992;289-294.
4. Iijima K., Sun S., Cyong J.C., Jyonouchi H. Juzentaiho-to, a Japanese herbal medicine, modulated type 1 and Type 2 T cell responses in old BALB/c mice; Hoelen is one of the main active herbal components. American Journal of Chinese Medicine. 27:1999;191-203.
5. Jin R., Kurashige S. Effects of Chinese herbs on macrophage functions in N-butyl-N-butanolnitrosoamine treated mice. Immunopharmacology and Immunotoxicology. 18:1996;105-114.
6. Jin R., Kurashige S. Effect of Shi-ka-ron on cytokine production of lymphocytes in mice treated with cyclophosphamide. American Journal of Chinese Medicine. 24:1996;37-44.
7. Jin R., Wan L.L., Mitsuishi T., Sato S., Akuzawa Y., Kodama K., Kurashige S. Effect of Shi-ka-ron and Chinese herbs on cytokine production of macrophage in immunocompromised mice. American Journal of Chinese Medicine. 22:1994;255-266.
8. Jin R., Wan L.L., Mitsuishi T., Kodama K., Kurashige S. Immunomodulative effects of Chinese herbs in mice treated with anti-tumor agent cyclophosphamide. Journal of the Pharmaceutical Society of Japan. 114:1994;533-538.
9. Joo J.J., Kim Y.S., Lee J.D., Choi D.Y., Koh H.K., Ahn B.C., Park D.S., Kang S.K., Kim C.H., Lee Y.H., Choi Y.T., Nam S.S. The Effect of Kongjindan aqua-acupuncture on the CD4+ T cell count at al. in rats were administered with MTX. The Journal of Korean Acupuncture and Moxibustion Society. 16:1999;179-202.
10. Kajimura K., Takagi Y., Miyano K., Sawabe Y., Mimura M., Sakagami Y., Yokoyama H., Yoneda K. Polysaccharide of Astragali radix enhances IgM antibody production in aged mice. Biological and Pharmaceutical Bulletin. 20:1997;1178-1182.
11. Kurashige S., Akuzawa Y., Endo F. Effects of Astragali radix extract on carcinogenesis, cytokine production, and cytotoxicity in mice treated with a carcinogen, N-butyl-N′-butanolnitrosoamine. Cancer Investigation. 17:1999;30-35.
12. Lau B.H.S., Ong P., Tosk J. Macrophage chemiluminescence modulated by Chinese medicinal herbs Astragalus membranaceus and Ligustrum luidum. Phytotherapy Research. 3:1989;148-153.
13. Lau B.H., Ruckle H.C., Botolazzo T., Lui P.D. Chinese medicinal herbs inhibit growth of murine renal cell carcinoma. Cancer Biotherapy. 9:1994;153-161.
14. Lee Y.S., Kim H.S., Kim S.K., Kim S.D. IL-6 mRNA expression in mouse peritoneal macrophages and NIH3T3 fibroblasts in response to Candida albicans. Journal of Microbiolgy and Biotechnology. 10:2000;8-15.
15. Liang H., Zhang Y., Geng B. The effect of Astragalus polysaccharides (APS) on cell mediated immunity (CMI) in burned mice. Chinese Journal of Plastic Surgery and Burns. 10:1994;138-141.
16. Mizuno M., Yamada J., Terai H., Kozukue N., Lee Y.S., Tsuchida H. Differences in immunomodulating effects between wild and cultured Panax Ginseng. Biochemical and Biophysical Research Communications. 200:1994;1672-1678.
17. Park J.W., Han I.S., Suh S.I., Baek W.K., Suh M.H. Effects of Ginseng Saponin on the cytokine gene expression in human immune system. Jouranl of Ginseng Research. 20:1996;15-22.
18. Park J.W., Choi Y.J., Jang M.A., Lee Y.S., Jun D.Y., Suh S.I., Baek W.K., Suh M.H., Jin I.N., Kwon T.K. Chemopreventive agent resveratrol, a natural product derived from grapes, reversibly inhibits progression through S and G2 phases of the cell cycle in U937 cells. Cancer Letters. 163:2001;43-49.
19. Prinz M., Häusler K.G., Kettenmann H., Hanisch U. adrenergic receptor stimulation selectively inhibits IL-12p40 release in microglia. Brain Research. 899:2001;264-270.
20. Rittenhaus J.R., Lui P.D., Lau B.H. Chinese medicinal herbs reverse macrophage suppression induced by urological tumors. The Journal of Urology. 146:1991;486-490.
21. Shan B.E., Yoshida Y., Sugiura T., Yamashita U. Stimulating activity of Chinese medicinal herbs on human lymphocytes in vitro. International Journal of Immunopharmacology. 21:1999;149-159.
22. Song B.K., Lee E.J., Kim H.K., Jin S.D., Kim S.J., Kim D.H. Effects of Astrgali radix on the function of murine immunocytes in vivo and in vitro. Korean Journal of Herbology. 13:1998;115-128.
23. Song Q., Kobayashi T., Xiu L.M., Hong T., Cyong J.C. Effects of Astragali root and Hedysari root on the murine B and T cell differentiation. Journal of Ethnopharmacology. 73:2000;111-119.
24. Thomson A.W. The Cytokine Handbook. 1994;32-53 Academic press, London.
25. Zhang M., Caragine T., wang H., Cohen P.S., Botchkina G., Soda K., Bianchi M., Ulrich P., Cerami A., Sherry B., Tracey K.J. Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: a counterregulatory mechanism that restrains the immune response. Journal of Experimental Medicine. 185:1997;1759-1768.
26. Zhao K.S., Mancini C., Doria G. Enhancement of the immune response in mice by Astragalus membranaceus extracts. Immunopharmacology. 20:1990;225-233.