Permeability of the flavonoids liquiritigenin and its glycosides in licorice roots and davidigenin, a hydrogenated metabolite of liquiritigenin, using human intestinal cell line Caco-2

Journal of Ethnopharmacology

Volumn 89, Issue 2-3, 2003, Pages 285-289

  Asano, Takayuki ^a   Ishihara, Kazuhisa ^a   Morota, Takashi ^a   Takeda, Shuichi ^a   Aburada, Masaki ^a  

^a TSUMURA AND CO   (Japan)

Author keywords

Caco 2; Davidigenin; Liquiritigenin; Liquiritin; Liquiritin apioside; Permeability coefficients (Papp)

Indexed keywords

ANTIALLERGIC AGENT; ANTITUSSIVE AGENT; DAVIDIGENIN; FLAVANOID; GLYCOSIDE; LIQUIRITIGENIN; LIQUIRITIN; LIQUIRITIN APIOSIDE; MANNITOL; PROPRANOLOL; UNCLASSIFIED DRUG;

ARTICLE; CARCINOMA CELL; CELL STRAIN CACO 2; CHEMICAL PARAMETERS; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG ABSORPTION; DRUG PENETRATION; EUCALYPTUS; GLYCYRRHIZA; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; TRANSCYTOSIS;

EID: 0242552334     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2003.09.009     Document Type: Article

References (24)

1. Akao T., Kida H., Kanaoka M., Hattori M., Kobashi K. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. Journal of Pharmacy and Pharmacology. 50:1998;1155-1160.
2. Artursson P. Epithelial transport of drugs in cell culture. I: anal absorbtive (Caco-2) cells. Journal of Pharmaceutical Science. 79:1990;476-482.
3. Artursson P., Karlsson J. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochemical and Biophysical Research Communications. 175:1991;880-885.
4. Chuan L., Homma M., Oka K. Characteristics of delayed excretion of flavonoids in human urine after administration of Shosaiko-To, a herbal medicine. Biological and Pharmaceutical Bulletin. 12:1998;1251-1257.
5. Cogburn J.N., Donovan M.G., Schasteen C.S. A model of human small intestinal absorptive cells. 1. Transport barrier. Pharmaceutical Research. 8:1991;210-216.
6. Hirohashi T., Suzuki H., Chu X.Y., Tamai I., Tsuji A., Sugiyama Y. Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2). Journal of Pharmacology and Experimental Therapeutics. 292:2000;265-270.
7. Homma M., Oka K., Taniguchi C., Niitsuma T., Hayashi T. Systematic analysis of post-administrative Saiboku-To urine by liquid chromatography to determine pharmacokinetics of traditional Chinese medicine. Biomedical Chromatography. 11:1997;125-131.
8. Hunter J., Hirst B.H., Shimmons N.L. Drug absorption limited by p-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers. Pharmaceutical Research. 10:1993;743-749.
9. Kitagawa I., Chen W.Z., Taniyama T., Harada E., Hori K., Kobayashi M., Jiali R. Quantitative determination of constituents in various licorice roots by means of high performance liquid chromatography. Yakugaku Zasshi. 118:1998;519-528.
10. Kobashi K., Akao T. Relation of intestinal bacteria to pharmacological effects of glycoside. Bioscience Microflora. 16:1997;1-7.
11. Meunier V., Bourrié M., Berger Y., Fabre G. The human intestinal epithelial cell line Caco-2; Pharmacological and pharmacokinetic applications. Cell Biology and Toxicology. 11:1995;187-194.
12. Miura H., Kitamura Y., Sugii M. Determination and synthesis of confusoside, a minor dihydrochalcone glycoside from Sympocos microcalyx Hay. Shoyakugaku Zasshi. 39:1985;312-315.
13. Nakajima, R., Sakakibara, I., Kubo, M., Higuchi, M., Sasaki, H., Okada, M., Morita, K., Kamei, J., 2001. In: Proceedings of the 48th Annual Meeting of the Japanese Society of Pharmacognosy Kanazawa abstract papers, pp. 144.
14. Shibata S., Saitoh T. Flavonoid compound in licorice root. Journal of the Indian Chemical Society. 55:1978;1184-1191.
15. Shimamura H., Nakai S., Yamamoto K., Hitomi N., Yumioka E. Biliary and urinary metabolites of liquritin in rats. Shoyakugaku Zassi. 44:1990;265-268.
16. Shimamura H., Suzuki H., Hanano M., Suzuki A., Tagaya O., Horie T., Sugiyama Y. Multiple systems for the biliary excretion of organic anions in rats: liquiritigenin conjugates as model compounds. Journal of Pharmacology and Experimental Therapeutics. 271:1994;370-378.
17. Taniguchi C., Homma M., Takano O., Hirano T., Oka K., Aoyagi Y., Niitsuma T., Hayashi T. Pharmacological effects of urinary products obtained after treatment with Saiboku-To, a herbal medicine for bronchial asthma, on type IV allergic reaction. Planta Medica. 66:2000;607-611.
18. Vaidyanathan J.B., Walle T. Transport and metabolism of the tea flavonoid (-)-epicatechin by the human intestinal cell line Caco-2. Pharmaceutical Research. 18:2001;1420-1425.
19. Walgren R.A., Karnaky K.J. Jr., Lindenmayer G.E., Walle T. Efflux of dietary flavonoid quercetin 4′-β glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2. Journal of Pharmacology and Experimental Therapeutics. 294:2000;830-836.
20. Walle U.K., Walle T. Taxol transport by human intestinal epithelial Caco-2 cells. Drug Metabolism and Disposition. 26:1998;343-346.
21. Walle U.K., Galijatovic A., Walle T. Transport of the flavonoid Chrysin and its conjugated metabolites by the human intestinal cell line Caco-2. Biochemical Pharmacology. 58:1999;431-438.
22. Yee S. In vitro permeability across Caco-2 cell (colonic) can predict in vivo (small intestinal) absorption in man-fact or myth. Pharmaceutical Research. 14:1997;763-766.
23. Yoneda K., Yamagata E., Tsujimura M. Studies on resources of crude drugs (V) comparison of the constituents of wild Glychyrrhiza uralensis and various chinese licorices obtained in Japanese marke. Shoyakugaku Zasshi. 44:1990;202-206.
24. Zuo F., Zhou M.Z., Yan M.Z., Liu M.L., Xiong Y.L., Zhang Q., Hong Y.S., Wen H.Y. Metabolism of constituents in Huangqin-Tang, a prescription in traditional Chinese medicine, by human intestinal flora. Biological and Pharmaceutical Bulletin. 25:2002;558-563.