Mutational analyses of the BbCRASP-1 protein of Borrelia burgdorferi identify residues relevant for the architecture and binding of host complement regulators FHL-1 and factor H

International Journal of Medical Microbiology

Volumn 299, Issue 4, 2009, Pages 255-268

  Kraiczy, Peter ^a   Hanssen Hübner, Christa ^a   Kitiratschky, Veronique ^b   Brenner, Christiane ^b   Besier, Silke ^a   Brade, Volker ^a   Simon, Markus M ^c   Skerka, Christine ^d   Roversi, Pietro ^e   Lea, Susan M ^e   Stevenson, Brian ^f   Wallich, Reinhard ^b   Zipfel, Peter F ^d,g  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^d HANS KNÖLL INSTITUTE   (Germany)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f UNIVERSITY OF KENTUCKY   (United States)

^g FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Borrelia burgdorferi; Complement; Immune evasion; Innate immunity; Lyme disease

Indexed keywords

COMPLEMENT FACTOR H; COMPLEMENT REGULATOR ACQUIRING SURFACE PROTEIN; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; PROTEIN FHL 1; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BORRELIA BURGDORFERI; CARBOXY TERMINAL SEQUENCE; COMPLEMENT FACTOR; CONTROLLED STUDY; CRYSTAL STRUCTURE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; SURFACE PLASMON RESONANCE;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BORRELIA BURGDORFERI; COMPLEMENT FACTOR H; DNA MUTATIONAL ANALYSIS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY;

EID: 63549092698     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2008.09.002     Document Type: Article

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