The use of CpG as an adjuvant to Toxoplasma gondii vaccination

Parasitology Research

Volumn 92, Issue 4, 2004, Pages 313-316

  Spencer, Jennifer A ^a   Smith, Bruce F ^a   Guarino, Anthony J ^a   Blagburn, Byron L ^a   Baker, Henry J ^a  

^a AUBURN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CPG DINUCLEOTIDE; DINUCLEOTIDE; IMMUNOLOGICAL ADJUVANT; PARASITE ANTIBODY; TOXOPLASMA GONDII VACCINE; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HUMORAL IMMUNITY; IMMUNIZATION; LETHAL DOSE; MOUSE; NONHUMAN; PARASITE SURVIVAL; PARASITE VIRULENCE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TEMPERATURE SENSITIVE MUTANT; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, PROTOZOAN; DINUCLEOSIDE PHOSPHATES; FEMALE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MICE; MICE, INBRED ICR; OLIGODEOXYRIBONUCLEOTIDES; PROTOZOAN VACCINES; SURVIVAL ANALYSIS; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL; VACCINATION;

BACTERIA (MICROORGANISMS); MAMMALIA; TOXOPLASMA GONDII;

EID: 1542614368     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-003-1039-7     Document Type: Article

References (26)

1. Chace JH, Hooker NA, Mildenstein KL, Krieg AM, Cowdery JS (1997) Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12. Clin Immunol Immunopathol 84:185-193
2. Cheadle MA, Lindsay DS, Blagburn BL (1999) Prevalence of antibodies to Neospora caninum in dogs. Vet Parasitol 85: 325-330
3. Corral RS, Petray PB (2001) CpG DNA as a Th1-promoting adjuvant in immunization against Trypanosoma cruzi. Vaccine 19:234-242
4. Desolme B, Mevelec MN, Buzoni-Gatel D, Bout D (2000) Induction of protective immunity against toxoplasmosis in mice by DNA immunization with a plasmid encoding Toxoplasma gondii GRA4 gene. Vaccine 18:2512-2521
5. Elkins KL, Rhinehart-Jones TR, Stibitz S, Conover JS, Klinman DM (1999) Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J Immunol 162:2291-2298
6. Fachado A, Rodriguez A, Angel SO, Pinto DC, Vila I, Acosta A, Amendoeira RR, Lannes-Vieira J (2003) Protective effect of a naked DNA vaccine cocktail against lethal toxoplasmosis in mice. Vaccine 21:1327-1335
7. Gavrilescu LC, Denkers, EY (2001) IFN-γ overproduction and high level apoptosis are associated with high but not low virulence Toxoplasma gondii infection. J Immunol 167:902-909
8. Gazzinelli RT, Hakim FT, Hieny S, Shearer GM, Sher A (1991) Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-γ production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J Immunol 146:286-292
9. Gomis S, Babiuk L, Godson DL, Allan B, Thrush T, Townsend H, Willson P, Waters E, Hecker R, Potter A (2003) Protection of chickens against Escherichia coli infections by DNA containing CpG motifs. Infect Immun 71:857-863
10. Gramzinski RA, Doolan DL, Sedegah M, Davis HL, Krieg AM, Hoffman SL (2001) Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice. Infect Immun 69:1643-1649
11. Jiang W, Baker HJ, Smith BF (2003) Mucosal immunization with Helicobacter, CpG DNA, and cholera toxin is protective. Infect Immun 71:40-46
12. Jones TR, Obaldia III N, Gramzinski RA, Charoenvit Y, Kolodny N, Kitov S, Davis HL, Krieg AM, Hoffman SL (1999) Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys. Vaccine 17:3065-3071
13. Khan IA, Casciotti L (1999) IL-15 prolongs the duration of CD8+ T cell-mediated immunity in mice infected with a vaccine strain of Toxoplasma gondii. J Immunol 163:4503-4509
14. Krahenbul JL, Remington JS (1982) Immunology of Toxoplasma and toxoplasmosis. In Cohen S, Warren KS (eds) Immunology of parasitic infections. Blackwell, London
15. Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, Koretzky GA, Klinman DM (1995) CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546-549
16. Krieg AM, Love-Homan, L, Yi AK, Harty JT (1998) CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J Immunol 161:2428-2434
17. Lee SW, Sung YC (1998) Immuno-stimulatory effects of bacterial-derived plasmids depend on the nature of the antigen in intramuscular DNA inoculations. Immunology 94:285-289
18. Lee Y-H, Channon JY, Matsuura T, Schwartzman JD, Shin D-W, Kasper L (1999) Functional and quantitative analysis of splenic T cell immune responses following oral Toxoplasma gondii infection in mice. Exp Parasitol 91:212-221
19. Liang H, Nishioka Y, Reich CF, Pisetsky DS, Lipsky PE (1996) Activation of human B cells by phosphorothioate oligodeoxynucleotides. J Clin Invest 98:1119-1129
20. Nielsen HV, Lauemoller SL, Christiansen L, Buus L, Fomsgaard A, Petersen E (2000) Complete protection against lethal T. gondii infection in mice immunized with a plasmid encoding the SAG1 gene. Infect Immun 67:6356-6363
21. Sayles PC, Johnson LL (1996) Intact immune defenses are required for mice to resist the ts-4 vaccine strain of Toxoplasma gondii. Infect Immun 64:3088-3092
22. Sayles PC, Gibson GW, Johnson LL (2000) B cells are essential for vaccination-induced resistance to virulent Toxoplasma gondii. Infect Immun 68:1026-1033
23. Spencer JA, Hill GM, Jezewski A, Young-White R, Blagburn BL (1999) The immune responses to Neospora caninum infection in BALB/c mice. Exp Biol Proc 202
24. Stacey KJ, Blackwell JM (1999) Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major. Infect Immun 67:3719-3726
25. Waldeland H, Frenkel JK (1983) Live and killed vaccines against toxoplasmosis in mice. J Parasitol 69:60-65
26. Yi AK, Klinman DM, Martin TL, Matson S, Krieg AM (1996) Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway. J Immunol 157:5394-5402