Serum IGF-I and hormonal responses to incremental exercise in athletes with and without left ventricular hypertrophy

Journal of Sports Science and Medicine

Volumn 8, Issue 1, 2009, Pages 67-76

  Zebrowska, Aleksandra ^a   Gasior, Zbigniew ^b   Langfort, Józef ^a,c  

^a INSTITUTE OF SPORT SCIENCES   (Poland)

^b MEDICAL UNIVERSITY OF SILESIA   (Poland)

^c POLISH ACADEMY OF SCIENCES   (Poland)

Author keywords

Anabolic hormones; Echocardiography; Endurance training; Heart; Somatomedins

Indexed keywords

EID: 63449132669     PISSN: None     EISSN: 13032968     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Bisi, G., Podio, V., Valetto, M.R., Bertuccio, G., Rio, G., Boghen, M.F., Berti, F., Muller, E.E. and Ghigo, E. (1999) Radionuclide angiocardiographic evaluation of the cardiovascular effects of recombinant human IGF-I in normal adults. European Journal of Endocrinology 140, 322-327.
2. Brink, M., Chrast, J., Mitch, W.E. and Delafontaine, P. (1999) Angiotensin II stimulates gene expression of cardiac insulin-like growth factor 1 and its receptor through effects on blood pressure and food intake. Hypertension 34, 1053-1059.
3. Bleumink, G.S., Schut, A.F., Sturkenboom, MC.J.M., Janssen, J.A.M.J.L., Witteman, J.C.M., van Duijn, C.M., Hofman, A.and Stricker, B.H.Ch. (2005) A promoter polymorphism of the insulin-like growth factor-I gene is associated with left ventricular hypertrophy. Heart 91, 239-240.
4. Catalucci, D., Latronico, M.V., Ellingsen, O. and Condorelli, G. (2008) Physiological myocardial hypertrophy: how and why? Frontiers in Bioscience 1(13), 312-324.
5. Culig, Z., Hobisch, A., Cronauer, M., Hittmair, A., Radmayer, C., Bartsch, G. and Klocker, H. (1995) Activation of androgen receptor by polypeptide growth factors and cellular regulators. World Journal of Urology 13, 285-289.
6. Decker, M.L., Janes, D.M., Barclay, M.M., Harger, L. and Decker, R.S. (1997) Regulation of adult cardiocyte growth: Effects of active and passive mechanical loading. American. Journal of Physiology 272, H2902-H2918.
7. Delafontaine, P., Yao-Hua, S. and Yangxin, L. (2004) Expression, Regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arteriosclerosis Thrombosis and Vascular Biology 24, 435-444.
8. Devereux, R.B., Alonso, R., Lutas, R., Gottlieb, G., Campo, E., Sachs, I. and Reiche, K.N. (1998) Echocardiogrphic assessment of left ventricular hypertrophy: comparison to necropsy finding. American Journal of Cardiology l57, 450-458.
9. Diez, J. (1999) Insulin growth factor I in essential hypertension. Kidney International 55, 744-759.
10. Donohue, T.J., Dworkin, L.D., Lango, M.N., Fliegner, K., Lango, R.P., Benstein, J.A., Slater, W.R. and Catanese, V.M. (1994) Induction of myocardial insulin-like growth factor-I gene expression in left ventricular hypertrophy. Circulation 89, 799-809.
11. Eliakim, A., Brasel, J.A., Mohan, S., Wong, W.L. and Cooper, D.M. (1998) Increased physical activity and the growth hormone-IGF-I axis in adolescent males. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 275, R308-R314.
12. Fischer, F., Schulte, H., Mohan, S., Tataru, M., Köhler, E., Assmann, G. and Eckardstein, A. (2004) Association of insulin-like growth factors, insulin growth factor binding proteins and acid-labile subunit with coronary heart disease. Clinical Endocrinology 61, 595-602.
13. Fletcher G.F., Balady G.J., Amsterdam E.A., Chaitman B., Eckel R., Fleg J., Froelicher V.F. Leon A., Piña I.L., Rodney R., Simons-Morton D.A., Williams M.A. and Bazzarre T. (2001) Exercise standards for testing and training. A statement for healthcare professionals from the America Heart Association. Circulation 104, 1694-1740.
14. Hanson, M.C., Fath, K.A., Alexander, R.W. and Delafontaine, P. (1993) Induction of cardiac insulin-like growth factor I gene expression in pressure overload hypertrophy. American Journal of Medicine and Science 306(2), 69-74.
15. Horio, T., Maki, T., Kishimoto, I., Okumura, H., Yoshihara, F., Suga, S., Takeo, S., Kawano, Y. and Kangawa, K. (2005) Production and autocrine/paracrine effects of endogenous insulin-like growth factor-1 in rat cardiac fibroblasts. Regulatory Peptides 124, 65-72.
16. Huang, Ch., Buchanan, D.L., Gordon, R.L., Scherman, M.J., Razzaq, J., White, K. and Buetow, D.E. (2003) Increased insulin-like growth factor-I gene expression precedes left ventricular cardiomyocytes hypertrophy in rapidly-hypertrophying rat model system. Cell Biochemistry and Function 21, 355-361.
17. Kasikcioglu, E., Oflaz, H., Akhan, H., Kayserilioglu, A. and Umman, B. (2005) Peak pulse pressure during exercise and left ventricular hypertrophy in athletes. Anatolian Journal of Cardiology 5, 64-65.
18. Kim, J., Wende, A.R., Sena, S., Theobald, H.A., Soto, J., Sloan, C., Wayment, B.E., Litwin, S.E., Holzenberger, M., LeRoith, D. and Abel, E.D. (2008) Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Molecular Endocrinology 22(11), 2531-2543.
19. Kobayashi, S., Kawashma, S., Sakoda, T., Ueyama, T., Hirase, T., Kawai, M., Toh, R., Iwai, K. and Yokoyama, M. (2004) Glycogen Synthase Kinase-3 is involved in the process of myocardial hypertrophy stimulated by insulin-like growth factor-1. Circulation Journal 68, 247-253.
20. Koziris, L.P., Hickson, R.C., Chatterton, R.T., Groseth, R.T., Christie, I.M., Goldflies, D.G. and Unterman, T.G. (1999) Serum levels of total and free IGF-I and IGFBP-3 are increased and maintained in long-term training. Journal Applied Physiology 86, 1436-1442.
21. Kraemer, W.J. (2000) Effects of exercise and alkalosis on serum insulinlike growth factor I and IGF-binding protein-3. Canadian Journal of Applied Physiology 25, 127-138.
22. Kupfer, I.M. and Rubin, S.A. (1992) Differential regulation of insulinlike growth factor I by growth hormone and thyroid hormone in the heart of juvenile hypophysectomized rats. Journal of Molecular and Cellular Cardiology 24, 631-639.
23. Levy, D., Savage D.D., Garrisonn, R.J., Anderson, K.M., Kannell, W.B. and Casterlli, W.P. (1997) Echocardiographic criteria for left ventricular hypertrophy: the Framingham heart study. American Journal of Cardiology 59, 656-960.
24. Manetta, J., Brun, J.F., Fedou, C., Maïmoun, L., Prefaut, C. and Mercier, J. (2003) Serum levels of insulin-like growth factor-I (IGF-I), and IGF-binding proteins-1 and-3 in middle-aged and young athletes versus sedentary men: relationship with glucose disposal. Metabolism 52, 821-826.
25. Manetta, J., Brun, J.F., Maïmoun, L., Callis, A., Prefaut, C. and Mercier J. (2002) Effect of training on the GH/IGF-I axis during exercise in middle-aged men: relationship to glucose homeostasis. American Journal of Physiology and Endocrinology 283, 929-936.
26. Marsh, J.D., Lehmann, M.H., Ritchie, R.H., Gwathmey, J.K., Green, G.E. and Schiebinger, R.J. (1998) Androgen receptors mediated hypertrophy in cardiac myocytes. Circulation 98, 256-261.
27. McMullen, J.R., Shioi, T., Huang, W.Y., Zhang, L., Tarnavski, O., Bisping, E., Schinke, M., Kong, S., Sherwood, MC., Brown, J., Rigi, L., Kang, P.M. and Izumo, S. (2004) The insulin like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase (p110alpha) pathway. Journal of Biological Chemistry 279, 4782-4793.
28. Mettauer, B., Geny, B., Landsdorf-Wolf, E., Charloux, A., Zhao, Q.M., Heitz-Naegelen, B., Epailly, E., Lampert, E. and Levy, F. (2001) Exercise training with a heart device: a hemodynamic, metabolic, and hormonal study. Medicine and Science Sports and Exercise 33, 2-9.
29. Modesti, P.A., Vanni, S., Bertolozzi, I., Cecioni, I., Lumachi, C., Perna, A.M., Boddi, M. and Gensini, G.F. (2004) Different growth factor in the right and left ventricles in experimental volume overload. Hypertension 43, 110-108.
30. Neri Serneri, G., Boddi, M., Modesti, P., Cecioni I., Coppo M., Padeletti L., Michelucci A., Colella A. and Galanti G. (2001) Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes. Circulation Research 89, 977-982.
31. Nguyen, U.N., Mougin, F., Simon-Rigaud, M.L., Rouillon, I.D., Marguel, P. and Regnard, J. (1998) Influence of exercise duration on serum insulin-like growth factor and its binding proteins in athletes. European Journal of Applied Physiology and Occupational Physiology 78, 533-537.
32. Nishimura, T., Yamada, Y. and Kawai, C. (1980) Echocardiographic evaluation of long-term effects of exercise on left ventricular hypertrophy and function in professional bicyclists. Circulation 10, 540-547.
33. Pelliccia, A., Maron, B.J., Spataro, A., Proschan, M. and Spirito, P. (1991) The upper limits of physiological hypertrophy in highly trained athletes. The New England Journal of Medicine 324, 295-301.
34. Pluim, B.M., Zwinderman, A.H., van der Laarse, A. and van der Wall, E.E. (1999) The athlete's heart: a meta-analysis of cardiac structure and function. Circulation 100, 336-344.
35. Ren, J., Samson, W.K. and Sowers, J.R. (1999) Insulin-like growth factor I as a cardiac hormone: physiological and pathophysiological implications in heart disease. Journal of Molecular and Cellular Cardiology 31, 2049-2061.
36. Rich, B.S. and Havens, S.A. (2004) The athletic heart syndrome. Current Sports Medicine Reports 3, 84-88.
37. Rosendal, L., Langberg, H., Flyvbjerg, A., Frystyk, J., Ørskov, H. and Kjær, M. (2002) Physical capacity influences the response of insulin-like growth factor and its binding proteins to training. Journal of Applied Physiology 93, 1669-1675.
38. Scheinowitz, M., Kessler-Icekson, G., Freimann, S., Zimmermann, R., Schaper, W., Golomb, E., Savion, N. and Eldar, M. (2003) Short-and long-term swimming exercise training increase myocardial insulin-like growth factor-I gene expression. Growth Hormone and IGF Research 13, 19-25.
39. Schwarz, A.J., Brasel, J., Hintz, R.L., Mohan, S. and Cooper, D.M. (1996) Acute effect of brief low-and high-intensity exercise on circulating insulin-like growth factor (IGF) I, II and IGHbinding protein-3 and its proteolysis in young healthy men. Journal of Clinical Endocrinology and Metabolism 81, 3492-3497.
40. Sharma, S. (2003) Athlete's heart-effect of age, sex, ethnicity and sporting discipline. Experimental Physiology 88, 665-669.
41. Strøm, C.C., Aplin, M., Ploug, T., Christofferson, T.E., Langfort, J., Viese, M., Galbo, H., Haunso, S. and Sheikh, S.P. (2005) Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy. FEBS Journal 272, 2684-2695.
42. Zanconato, S., Moromisato, D.Y., Moromisato, M.Y., Woods, J., Brasel, J.A., LeRoith, D., Roberts, C.T. and Cooper D.M. (1994) Effect of training and growth hormone suppression on insulin-like growth factor-I mRNA in young rats. Journal of Applied Physiology 76, 2204-2209.