Radionuclide angiocardiographic evaluation of the cardiovascular effects of recombinant human IGF-I in normal adults

European Journal of Endocrinology

Volumn 140, Issue 4, 1999, Pages 322-327

  Bisi, Gianni ^a,d   Podio, Valerio ^a   Valetto, Maria Rosa ^a   Broglio, Fabio ^a   Bertuccio, Giovanni ^a   Del Rio, Graziano ^b   Boghen, Muni F ^a   Berti, Ferruccio ^c   Muller, Eugenio E ^c   Ghigo, Ezio ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN C;

ADULT; ANGIOCARDIOGRAPHY; ARTICLE; CARDIOVASCULAR DISEASE; CATECHOLAMINE RELEASE; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART PROTECTION; HUMAN; HUMAN EXPERIMENT; MALE; MUSCLE GROWTH; NORMAL HUMAN; PRIORITY JOURNAL; SCINTIANGIOGRAPHY; SUBCUTANEOUS DRUG ADMINISTRATION;

ADULT; CATECHOLAMINES; HEART; HEMODYNAMIC PROCESSES; HUMAN GROWTH HORMONE; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; MALE; RADIONUCLIDE VENTRICULOGRAPHY; RECOMBINANT PROTEINS;

EID: 0032912788     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1400322     Document Type: Article

References (51)

1. Saccà L, Cittadini A & Fazio S. Growth hormone and the heart. Endocrine Reviews 1994 15 555-573.
2. Isgaard J & Friberg P. Regulation of insulin-like growth factor I (IGF-I) and receptors for IGF-I and growth hormone in the heart. Endocrinology and Metabolism 1997 4 (Suppl B) 15-19.
3. Mathews LS, Enberg B & Norstedt G. Regulation of rat growth hormone receptor gene expression. Journal of Biological Chemistry 1989 17 9905-9910.
4. Murphy LJ, Bell GI, Duckworth L & Friesen G. Identification, characterization and regulation of a rat complimentary deoxyribonucleic acid which encodes insulin-like growth factor I. Endocrinology 1987 121 684-691.
5. Guron G, Friberg P, Wickman A, Brantsing C, Gabrielsson B & Isgaard J. Cardiac insulin-like growth factor I and growth hormone receptor expression in renal hypertension. Hypertension 1996 27 636-642.
6. Isgaard J, Wahlander H, Adams MA & Friberg P. Increased expression of growth hormone receptor mRNA and insulin-like growth factor I mRNA in volume overloaded hearts. Hypertension 1994 23 884-888.
7. Russel-Jones DL, Leach RM, Ward JPT & Thomas CR. Insulin-like growth factor-I gene expression is increased in the right ventricle hypertrophy induced by chronic hypoxia in the rat. Journal of Molecular Endocrinology 1993 10 99-102.
8. Delafontaine P. Insulin-like growth factor I and its binding proteins in the cardiovascular system. Cardiovascular Research 1995 30 825-834.
9. Engelmann GL, Boehm KD, Haskell JF, Khairallah PA & Ilan J. Insulin-like growth factors and neonatal cardiomyocyte development: ventricular gene expression and membrane receptor variations in normotensive and hypertensive rats. Molecular and Cellular Endocrinology 1989 63 1-14.
10. Guse AH, Kiess W, Funk B, Kessler U, Berg I & Gercken G. Identification and characterization of insulin-like growth factor receptors on adult rat cardiac myocytes: linkage to inositol 1,4,5-trisphosphate formation. Endocrinology 1992 130 145-151.
11. Isgaard J, Nilsson A, Vilkman K & Isaksson OGP. Growth hormone regulates the level of insulin-like growth factor mRNA in rat skeletal muscle. Journal of Endocrinology 1989 120 107-112.
12. Donath MY, Zapf J, Eppenberger-Eberhardt M, Froesch ER & Eppenberger HM. Insulin-like growth factor I stimulates myofibril development and decreases smooth muscle-actin of adult cardiomyocytes. Proceedings of the National Academy of Sciences of the USA 1994 91 1686-1690.
13. Donohue TJ, Dworkin LD, Lango MN, Fliegner K, Lango RP, Benstein JA et al. Induction of myocardial insulin-like growth factor-I gene expression in left ventricular hypertrophy. Circulation 1994 89 799-809.
14. Ito H, Hiroe M, Hirata Y, Tsujino M, Adachi S, Shichiri M et al. Insulin-like growth factor-I induces hypertrophy with enhanced expression of muscle specific genes in cultured rat cardiomyocytes. Circulation 1993 87 1715-1721.
15. Duerr RL, Huang S, Miraliakbar HR, Clark R, Chien KR & Ross J. Insulin-like growth factor-I enhances ventricular hypertrophy and function during the onset of experimental cardiac failure. Journal of Clinical Investigation 1995 95 619-627.
16. Cittadini A, Stromer H, Katz SE, Clark R, Moses AC, Morgan JP et al. Differential cardiac effects of growth hormone and insulin-like growth factor I in the rat. A combined in vivo and in vitro evaluation. Circulation 1996 93 800-809.
17. Florini JR & Ewton DZ. Induction of gene expression in muscle by IGFs. Growth Regulation 1992 2 23-29.
18. Guler HP, Schmid C, Zapf J & Froesch ER. Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects Proceedings of the National Academy of Sciences of the USA 1988 86 326-330.
19. Fuller J, Mynett JR & Sugden PH. Stimulation of cardiac protein synthesis by insulin-like growth factors. Biochemical Journal 1992 282 85-90.
20. Buerke M, Murohara T, Skurk C, Nuss C, Tomaselli K & Lefer AM. Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion. Proceedings of the National Academy of Sciences of the USA 1995 92 8031-8035.
21. Ambler GR, Johnston BM, Maxwell L, Gavin JB & Gluckmann PD. Improvement of doxorubicin induced cardiomyopathy in rats treated with insulin-like growth factor I. Cardiovascular Research 1993 27 1368-1373.
22. Johannsson G, Bengtsson BA, Andersson B, Isgaard J & Caidahl K. Long-term cardiovascular effects of growth hormone treatment in GH-deticient adults. Preliminary data in a small group of patients. Clinical Endocrinology 1996 45 305-314.
23. Amato G, Carella C, Fazio S, La Montagna G, Cittadini A, Sabatini D et al. Body composition, bone metabolism and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses. Journal of Clinical Endocrinology and Metabolism 1993 77 1671-1676.
24. Merola B, Cittadini A, Colao A, Longobardi S, Fazio S, Sabatini D et al. Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency. Journal of Clinical Endocrinology and Metabolism 1993 77 1658-1661.
25. Fazio S, Biondi B, Sabatini D, Cuocolo A, Tommaselli AP, Lombardi G et al. Long-term growth hormone deficiency as a cause of cardiomyopathy and its reversibility with specific replacement therapy. Journal of Clinical Endocrinology and Metabolism 1996 81 887-890.
26. Valcavi R, Gaddi O, Zini M, Iavicoli M, Mellino V & Portioli I. Cardiac performance and mass in adults with hypopituitarism: effect of one year of growth hormone treatment. Journal of Clinical Endocrinology and Metabolism 1995 80 659-666.
27. Vetter U, Kupferschmid C, Lang D & Pentz S. Insulin-like growth factors and insulin increase the contractility of neonatal rat cardiocytes in vitro. Basic Research in Cardiology 1998 83 647-654.
28. Johnston DM, Gluckmann PD, Bratt CM, Ambler GR & Lubbe WF. Insulin-like growth factors elicit positive inotropic responses in isolated rat heart. Growth Regulation 1994 4 44 (Abstract).
29. Russel Jones DL, Bates AI, Umpleby AM, Hennessy TR, Bowes SB, Hopkins KD et al. A comparison of the effect of IGF-I and insulin on glucose metabolism, fat metabolism and the cardiovascular system in normal human volunteers. European Journal of Endocrinology 1995 25 403-411.
30. Donath MY, Jenni R, Brunner HP, Anrig M, Kohli S, Glatz Y et al. Cardiovascular and metabolic effects of insulin-like growth factor-I at rest and during exercise in humans. Journal of Clinical Endocrinology and Metabolism 1996 81 4089-4094.
31. Burow RD, Strauss HW, Singleton R, Pond M, Rehn T, Bailey IK et al. Analysis of left ventricular function from multiple gated acquisition cardiac blood pool imaging. Comparison to contrast angiography. Circulation 1977 56 1024-1028.
32. Okada RD, Kirshenbaum HD, Kushner FG, Strauss HW, Dinsmore RE, Newell JB et al. Observer variance in the qualitative evaluation of left ventricular wall motion and the quantitation of left ventricular ejection fraction using rest and exercise multigated blood pool imaging. Circulation 1990 61 128-136.
33. Links JM, Becker LC, Shindledecker JG, Guzman P, Burow RD, Nickoloff EL et al. Measurement of absolute left ventricular volume from gated blood pool studies. Circulation 1982 65 82-91.
34. Kerr D, Tamborlane WV, Rife F & Sherwin RS. Effects of IGF-I on the responses to and recognition of hypoglycaemia in humans. Journal of Clinical Investigation 1993 91 141-143.
35. Ghigo E, Gianotti L, Arvat E, Ramunni J, Valetto MR, Broglio F et al. Effect of rhIGF-I administration on GH secretion both spontaneous and stimulated by GHRH or Hexarelin, a peptidyl GH secretagogue, in humans. Journal of Clinical Endocrinology and Metabolism 1999 84 285-290.
36. Vaccarello MA, Diamon FB, Guevara-Aguirre J, Rosenbloom AL, Fielder PJ, Gargosky S et al. Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency - Laron syndrome. Journal of Clinical Endocrinology and Metabolism 1993 77 273-280.
37. Trainer PJ, Holly J, Medbak S, Rees LH & Besser GM. The effect of recombinant IGF-I on anterior pituitary function in healthy volunteers. Clinical Endocrinology 1994 41 515-522.
38. Ghigo E, Aimaretti G, Gianotti L, Bellone J, Arvat E & Camanni F. New approach to the diagnosis of growth hormone deficiency in adults. European Journal of Endocrinology 1996 134 352-356.
39. Hartman ML, Clayton PE, Johnson ML, Celnikel A, Periman AJ, Alberti KGMM & Thorner MO. A low dose euglycemic infusion of recombinant human insulin-like growth factor I rapidly suppresses fasting-enhanced pulsatile growth hormone secretion in humans. Journal of Clinical Investigation 1993 91 2453-2462.
40. Jones J & Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocrine Reviews 1995 16 3-34.
41. Guler HP, Schmid C, Zapf J & Froesch ER. Effect of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects. Proceedings of the National Academy of Sciences of the USA 1989 86 2868-2872.
42. Copland AC & Nair KS. Recombinant human insulin-like growth factor I increases forearm blood flow. Journal of Clinical Endocrinology and Metabolism 1994 79 230-232.
43. Fryburg DA. IGF-I exerts GH and insulin-like actions on human muscle protein metabolism. American Journal of Physiology 1994 267 E331-E336.
44. Kiowski LV, Stoschisky K, Kim JH, Hussain MA & Froesch ER. Insulin-like growth factor I causes endothelium-dependent arterial vasodilatation. Circulation 1994 90 I-242 (Abstract).
45. Hirschberg R & Kopple JD. Evidence that insulin-like growth factor I increases renal plasma flow and glomerular filtration rate in fasted rats. Journal of Clinical Investigation 1989 83 326-330.
46. 2+ handling and enhance cardiac performance. Circulation Research 1996 79 227-236.
47. Firestone NS, Ribaric S & Mason WT. The effect of insulin-like growth factor-I on adult rat cardiac contractility. Molecular and Cellular Biochemistry 1996 164 223-229.
48. Isgaard J, Nillson A, Vikman K & Isaksson OGP. Growth hormone regulates the level of insulin-like growth factor I mRNA in rat skeletal muscle. Journal of Endocrinology 1989 120 107-112.
49. Gosteli-Peter MA, Winterhalter KH, Schmid C, Froesch ER & Zapf J. Expression and regulation of insulin-like growth factor I (IGF-I) and IGF binding protein messenger ribonucleic acid levels in tissues of hypophysectomized rats infused with IGF-I and growth hormone. Endocrinology 1994 135 2558-2567.
50. Volterrani M, Desenzani P, Lorusso R, d'Aloia A, Manelli F & Giustina A. Haemodynamic effects of intravenous growth hormone in congestive heart failure. Lancet 1997 359 1067-1068.
51. Bisi G, Podio V, Valetto MR, Broglio F, Bertuccio G, Boghen MF et al. The acute administration of Hexarelin, a synthetic GH-releasing hexapeptide, but not growth hormone, increases left ventricular ejection fraction in humans. Circulation 1997 96 I-361 (Abstract).