Wnt signaling inhibits cementoblast differentiation and promotes proliferation

Bone

Volumn 44, Issue 5, 2009, Pages 805-812

  Nemoto, Eiji ^a   Koshikawa, Yohei ^a   Kanaya, Sousuke ^a   Tsuchiya, Masahiro ^a   Tamura, Masato ^b   Somerman, Martha J ^c   Shimauchi, Hidetoshi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Cementoblast; Differentiation; In vitro; Proliferation; Wnt signaling

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; BONE SIALOPROTEIN; CYCLIN D1; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; OSTEOCALCIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR OCN; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3A PROTEIN;

ANIMAL CELL; ARTICLE; BLAST CELL; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CEMENTOBLAST; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; IN VITRO STUDY; MESENCHYME CELL; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEM CELL; TOOTH DEVELOPMENT; TRANSCRIPTION REGULATION;

ALKALINE PHOSPHATASE; ANIMALS; BETA CATENIN; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CYCLIN D1; DENTAL CEMENTUM; ENZYME ACTIVATION; LITHIUM CHLORIDE; MICE; MICROSCOPY, FLUORESCENCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; WNT PROTEINS;

EID: 63449121771     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2008.12.029     Document Type: Article

References (50)

1. Saygin N.E., Giannobile W.V., and Somerman M.J. Molecular and cell biology of cementum. Periodontol. 2000 24 (2000) 73-98
2. Bosshardt D.D. Are cementoblasts a subpopulation of osteoblasts or a unique phenotype?. J. Dent. Res. 84 (2005) 390-406
3. D'Errico J.A., MacNeil R.L., Takata T., Berry J., Strayhorn C., and Somerman M.J. Expression of bone associated markers by tooth root lining cells, in situ and in vitro. Bone 20 (1997) 117-126
4. D'Errico J.A., Berry J.E., Ouyang H., Strayhorn C.L., Windle J.J., and Somerman M.J. Employing a transgenic animal model to obtain cementoblasts in vitro. J. Periodontol. 71 (2000) 63-72
5. Kitagawa M., Tahara H., Kitagawa S., Oka H., Kudo Y., Sato S., et al. Characterization of established cementoblast-like cell lines from human cementum-lining cells in vitro and in vivo. Bone 39 (2006) 1035-1042
6. Zhao M., Xiao G., Berry J.E., Franceschi R.T., Reddi A., and Somerman M.J. Bone morphogenetic protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype. J. Bone Miner. Res. 17 (2002) 1441-1451
7. Logan C.Y., and Nusse R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20 (2004) 781-810
8. Miller J.R. The Wnts. Genome Biol. 3 (2002) REVIEWS3001
9. Aberle H., Bauer A., Stappert J., Kispert A., and Kemler R. beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 16 (1997) 3797-3804
10. Gong Y., Slee R.B., Fukai N., Rawadi G., Roman-Roman S., Reginato A.M., et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107 (2001) 513-523
11. Kato M., Patel M.S., Levasseur R., Lobov I., Chang B.H., Glass II D.A., et al. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J. Cell Biol. 157 (2002) 303-314
12. Boyden L.M., Mao J., Belsky J., Mitzner L., Farhi A., Mitnick M.A., et al. High bone density due to a mutation in LDL-receptor-related protein 5. N. Engl. J. Med. 346 (2002) 1513-1521
13. Little R.D., Carulli J.P., Del Mastro R.G., Dupuis J., Osborne M., Folz C., et al. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am. J. Hum. Genet. 70 (2002) 11-19
14. Bain G., Muller T., Wang X., and Papkoff J. Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction. Biochem. Biophys. Res. Commun. 301 (2003) 84-91
15. Gaur T., Lengner C.J., Hovhannisyan H., Bhat R.A., Bodine P.V., Komm B.S., et al. Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J. Biol. Chem. 280 (2005) 33132-33140
16. Rawadi G., Vayssiere B., Dunn F., Baron R., and Roman-Roman S. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J. Bone Miner. Res. 18 (2003) 1842-1853
17. de Boer J., Siddappa R., Gaspar C., van Apeldoorn A., Fodde R., and van Blitterswijk C. Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells. Bone 34 (2004) 818-826
18. Boland G.M., Perkins G., Hall D.J., and Tuan R.S. Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J. Cell. Biochem. 93 (2004) 1210-1230
19. van der Horst G., van der Werf S.M., Farih-Sips H., van Bezooijen R.L., Lowik C.W., and Karperien M. Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells. J. Bone Miner. Res. 20 (2005) 1867-1877
20. Eijken M., Meijer I.M., Westbroek I., Koedam M., Chiba H., Uitterlinden A.G., et al. Wnt signaling acts and is regulated in a human osteoblast differentiation dependent manner. J. Cell. Biochem. 104 (2008) 568-579
21. Liu F., Chu E.Y., Watt B., Zhang Y., Gallant N.M., Andl T., et al. Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev. Biol. 313 (2008) 210-224
22. Sarkar L., and Sharpe P.T. Expression of Wnt signalling pathway genes during tooth development. Mech. Dev. 85 (1999) 197-200
23. van Genderen C., Okamura R.M., Farinas I., Quo R.G., Parslow T.G., Bruhn L., et al. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev. 8 (1994) 2691-2703
24. Andl T., Reddy S.T., Gaddapara T., and Millar S.E. WNT signals are required for the initiation of hair follicle development. Dev. Cell 2 (2002) 643-653
25. Jarvinen E., Salazar-Ciudad I., Birchmeier W., Taketo M.M., Jernvall J., and Thesleff I. Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 18627-18632
26. Nakashima A., Katagiri T., and Tamura M. Cross-talk between Wnt and bone morphogenetic protein 2 (BMP-2) signaling in differentiation pathway of C2C12 myoblasts. J. Biol. Chem. 280 (2005) 37660-37668
27. Hedgepeth C.M., Conrad L.J., Zhang J., Huang H.C., Lee V.M., and Klein P.S. Activation of the Wnt signaling pathway: a molecular mechanism for lithium action. Dev. Biol. 185 (1997) 82-91
28. Klein P.S., and Melton D.A. A molecular mechanism for the effect of lithium on development. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 8455-8459
29. Jackson A., Vayssiere B., Garcia T., Newell W., Baron R., Roman-Roman S., et al. Gene array analysis of Wnt-regulated genes in C3H10T1/2 cells. Bone 36 (2005) 585-598
30. Komori T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89 (1997) 755-764
31. Otto F., Thornell A.P., Crompton T., Denzel A., Gilmour K.C., Rosewell I.R., et al. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89 (1997) 765-771
32. Nakashima K., Zhou X., Kunkel G., Zhang Z., Deng J.M., Behringer R.R., et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108 (2002) 17-29
33. Kahler R.A., and Westendorf J.J. Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter. J. Biol. Chem. 278 (2003) 11937-11944
34. Kahler R.A., Galindo M., Lian J., Stein G.S., van Wijnen A.J., and Westendorf J.J. Lymphocyte enhancer-binding factor 1 (Lef1) inhibits terminal differentiation of osteoblasts. J. Cell. Biochem. 97 (2006) 969-983
35. Sherr C.J. Cancer cell cycles. Science 274 (1996) 1672-1677
36. Krishnan V., Bryant H.U., and MacDougald O.A. Regulation of bone mass by Wnt signaling. J. Clin. Invest. 116 (2006) 1202-1209
37. Vaes B.L., Dechering K.J., van Someren E.P., Hendriks J.M., van de Ven C.J., Feijen A., et al. Microarray analysis reveals expression regulation of Wnt antagonists in differentiating osteoblasts. Bone 36 (2005) 803-811
38. Scheller E.L., Chang J., and Wang C.Y. Wnt/beta-catenin inhibits dental pulp stem cell differentiation. J. Dent. Res. 87 (2008) 126-130
39. Nishio Y., Dong Y., Paris M., O'Keefe R.J., Schwarz E.M., and Drissi H. Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene. Gene 372 (2006) 62-70
40. Roca H., Phimphilai M., Gopalakrishnan R., Xiao G., and Franceschi R.T. Cooperative interactions between RUNX2 and homeodomain protein-binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene. J. Biol. Chem. 280 (2005) 30845-30855
41. Harada H., Tagashira S., Fujiwara M., Ogawa S., Katsumata T., Yamaguchi A., et al. Cbfa1 isoforms exert functional differences in osteoblast differentiation. J. Biol. Chem. 274 (1999) 6972-6978
42. Ducy P., Zhang R., Geoffroy V., Ridall A.L., and Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89 (1997) 747-754
43. Hovanes K., Li T.W., Munguia J.E., Truong T., Milovanovic T., Lawrence Marsh J., et al. Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. Nat. Genet. 28 (2001) 53-57
44. Filali M., Cheng N., Abbott D., Leontiev V., and Engelhardt J.F. Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter. J. Biol. Chem. 277 (2002) 33398-33410
45. Shtutman M., Zhurinsky J., Simcha I., Albanese C., D'Amico M., Pestell R., et al. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 5522-5527
46. Shen R., Wang X., Drissi H., Liu F., O'Keefe R.J., and Chen D. Cyclin D1-cdk4 induce runx2 ubiquitination and degradation. J. Biol. Chem. 281 (2006) 16347-16353
47. Neth P., Ciccarella M., Egea V., Hoelters J., Jochum M., and Ries C. Wnt signaling regulates the invasion capacity of human mesenchymal stem cells. Stem Cells 24 (2006) 1892-1903
48. Yun M.S., Kim S.E., Jeon S.H., Lee J.S., and Choi K.Y. Both ERK and Wnt/beta-catenin pathways are involved in Wnt3a-induced proliferation. J. Cell. Sci. 118 (2005) 313-322
49. Caverzasio J., and Manen D. Essential role of Wnt3a-mediated activation of mitogen-activated protein kinase p38 for the stimulation of alkaline phosphatase activity and matrix mineralization in C3H10T1/2 mesenchymal cells. Endocrinology 148 (2007) 5323-5330
50. Kim S.E., Lee W.J., and Choi K.Y. The PI3 kinase-Akt pathway mediates Wnt3a-induced proliferation. Cell Signal 19 (2007) 511-518