Wnt/β-catenin inhibits dental pulp stem cell differentiation

Journal of Dental Research

Volumn 87, Issue 2, 2008, Pages 126-130

  Scheller, E L ^a   Chang, J ^b   Wang, C Y ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UCLA SCHOOL OF DENTISTRY   (United States)

Author keywords

Dental pulp; Mineralization; Osteopontin; Stem cell; Wnt

Indexed keywords

ALIZARIN; ALKALINE PHOSPHATASE; ANTHRAQUINONE DERIVATIVE; BETA CATENIN; COLLAGEN TYPE 1; COLORING AGENT; CTNNB1 PROTEIN, HUMAN; DIAGNOSTIC AGENT; OSTEOPONTIN; UNCLASSIFIED DRUG; WNT1 PROTEIN;

ARTICLE; BONE MINERALIZATION; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DRUG ANTAGONISM; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; HUMAN; NORTHERN BLOTTING; ODONTOBLAST; PHYSIOLOGY; POLYMERASE CHAIN REACTION; RETROVIRUS; SIGNAL TRANSDUCTION; STEM CELL; TOOTH PULP; WESTERN BLOTTING;

ALKALINE PHOSPHATASE; ANTHRAQUINONES; BETA CATENIN; BLOTTING, NORTHERN; BLOTTING, WESTERN; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN TYPE I; COLORING AGENTS; DENTAL PULP; GENETIC VECTORS; HUMANS; ODONTOBLASTS; OSTEOPONTIN; POLYMERASE CHAIN REACTION; RETROVIRIDAE; SIGNAL TRANSDUCTION; STEM CELLS; TRANSDUCTION, GENETIC; WNT1 PROTEIN;

EID: 39149133149     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910808700206     Document Type: Article

References (25)

1. Boland GM, Perkins G, Hall DJ, Tuan RS (2004). Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J Cell Biochem 93:1210-1230.
2. Boskey AL, Spevak L, Paschalis E, Doty SB, McKee MD (2002). Osteopontin deficiency increases mineral content and mineral crystallinity in mouse bone. Calcif Tissue Int 71:145-154.
3. Boyden LM, Mao J, Belsky J, Mitzner L, Farhi A, Mitnick MA, et al. (2002). High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 346:1513-1521.
4. Chen S, Guttridge DC, You Z, Zhang Z, Fribley A, Mayo MW, et al. (2001). Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. J Cell Biol 152:87-96.
5. Cheng SL, Yang JW, Rifas L, Zhang SF, Avioli LV (1994). Differentiation of human bone marrow osteogenic stromal cells in vitro: induction of the osteoblast phenotype by dexamethasone. Endocrinology 134:277-286.
6. Cho HH, Kim YJ, Kim SJ, Kim JH, Bae YC, Ba B, et al. (2006). Endogenous Wnt signaling promotes proliferation and suppresses osteogenic differentiation in human adipose derived stromal cells. Tissue Eng 12:111-121.
7. Day TF, Guo X, Garrett-Beal L, Yang Y (2005). Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 8:739-750.
8. de Boer J, Siddappa R, Gaspar C, van Apeldoorn A, Fodde R, van Blitterswijk C (2004). Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells. Bone 34:818-826.
9. Gaur T, Lengner CJ, Hovhannisyan H, Bhat RA, Bodine PV, Komm BS, et al. (2005). Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J Biol Chem 280:33132-33140.
10. Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, et al. (2001). LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107:513-523.
11. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S (2000). Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA 97:13625-13630.
12. Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, et al. (2002). Stem cell properties of human dental pulp stem cells. J Dent Res 81:531-535.
13. Holmen SL, Zylstra CR, Mukherjee A, Sigler RE, Faugere MC, Bouxsein ML, et al. (2005). Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem 280:21162-21168.
14. Jaiswal N, Haynesworth SE, Caplan AI, Bruder SP (1997). Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem 64:295-312.
15. Jarvinen E, Salazar-Ciudad I, Birchmeier W, Taketo MM, Jernvall J, Thesleff I (2006). Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling. Proc Natl Acad Sci USA 103:18627-18632.
16. Kang S, Bennett CN, Gerin I, Rapp LA, Hankenson KD, Macdougald OA (2007). WNT signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma. J Biol Chem 282:14515-14524.
17. Kratochwil K, Galceran J, Tontsch S, Roth W, Grosschedl R (2002). FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. Genes Dev 16:3173-3185.
18. Krishnan V, Bryant HU, Macdougald OA (2006). Regulation of bone mass by Wnt signaling. J Clin Invest 116:1202-1209.
19. Liu J, Jin T, Ritchie HH, Smith AJ, Clarkson BH (2005). In vitro differentiation and mineralization of human dental pulp cells induced by dentin extract. In Vitro Cell Dev Biol Anim 41:232-238.
20. Reya T, Clevers H (2005). Wnt signalling in stem cells and cancer. Nature 434:843-850.
21. Sasaki T, Ito Y, Xu X, Han J, Bringas P Jr, Maeda T, et al. (2005). LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev Biol 278:130-143.
22. Yang F, Yamashita J, Tang E, Wang HL, Guan K, Wang CY (2004). The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop. J Immunol 172:2446-2452.
23. You Z, Ouyang H, Lopatin D, Polver PJ, Wang CY (2001). Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity. J Biol Chem 276:26398-26404.
24. You Z, Saims D, Chen S, Zhang Z, Guttridge DC, Guan KL, et al. (2002). Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol 157:429-440.
25. Zhang W, Walboomers XF, Shi S, Fan M, Jansen JA (2006). Multilineage differentiation potential of stem cells derived from human dental pulp after cryopreservation. Tissue Eng 12:2813-2823.