Toward the rational design of protein kinase casein kinase-2 inhibitors

Pharmacology and Therapeutics

Volumn 93, Issue 2-3, 2002, Pages 159-168

  Sarno, Stefania ^a   Moro, Stefano ^a   Meggio, Flavio ^a   Zagotto, Giuseppe ^a   Dal Ben, Diego ^a   Ghisellini, Paola ^b   Battistutta, Roberto ^a   Zanotti, Giuseppe ^a   Pinna, Lorenzo A ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

CK2; Emodin; Flavonoids; Inhibitors; Protein kinase; Tetrabromobenzotriazole

Indexed keywords

1,8 DIHYDROXYXANTHEN 9 ONE; 2,7 DIHYDROXYFLUOREN 9 ONE; 4,5 DIHYDROXY 1 NITROANTHRAQUINONE; 4,5,6,7 TETRABROMO 1H BENZOTRIAZOLE; 4,5,6,7 TETRABROMO 2 AZABENZIMIDAZOLE; 5,6 DICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)BENZIMIDAZOLE; ALOE EMODIN; ANTHRAQUINONE DERIVATIVE; APIGENIN; BENZIMIDAZOLE DERIVATIVE; CASEIN KINASE II; CHRYSIN; CHRYSOPHANIC ACID; DANTRON; EMODIN; FISETIN; FLAVONOID; HYDROXYL GROUP; MORIN; MYRICETIN; NITROCHRYSOPHANIC ACID; PROTEIN KINASE INHIBITOR; QUERCETIN; UNCLASSIFIED DRUG; 4,5,6,7-TETRABROMO-2-AZABENZIMIDAZOLE; ENZYME INHIBITOR; PROTEIN SERINE THREONINE KINASE; TRIAZOLE DERIVATIVE;

CARCINOGENICITY; CONFERENCE PAPER; DRUG DESIGN; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; PRIORITY JOURNAL; VIRUS INFECTION; ANIMAL; COMPUTER SIMULATION; DRUG ANTAGONISM; PHOSPHORYLATION; RAT; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMAL; COMPUTER SIMULATION; EMODIN; ENZYME INHIBITORS; HUMAN; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; TRIAZOLES; ANIMALS; CASEIN KINASE II; HUMANS;

EID: 0035990903     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(02)00185-7     Document Type: Conference Paper

References (44)

1. Significance of casein kinase system in cell growth and proliferation with emphasis on studies of the androgenic regulation of prostate
2. The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2
3. Structural features underlying selective inhibition of protein kinase CK2 by ATP-site directed tetrabromo-benzotriazole
4. Oncogenic kinase signalling
5. Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor
6. Selective inhibition of a cyclic nucleotide independent protein kinase (G type casein kinase) by quercetin and related polyphenols
7. Specificity and mechanism of action of some commonly used protein kinase inhibitors
8. The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo
9. Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin
10. Differential effects of flavonoids as inhibitors of tyrosin protein kinases and serine/threonine protein kinases
11. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
12. Inhibition of casein kinase II by heparin
13. Abnormal casein kinases
14. Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine
15. A role for protein kinase CK2 in cell proliferation: Evidence using a kinase-inactive mutant of CK2 catalytic subunit α
16. Regulation of casein kinase II by growth factors: A reevaluation
17. Tyrosine versus serine/threonine phosphorylation by protein kinase casein kinase-2. A study with peptide substrates derived from immunophilin Fpr3
18. Random tyrosine and glutamic acid-containing polymers are very powerful inhibitors of casein kinase-2
19. Endogenous phosphate acceptor proteins for rat liver cytosolic casein kinases
20. Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1
21. Substrate specificity of protein kinase CK2
22. Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 Å resolution
23. GTP plus water mimic ATP in the active site of protein kinase CK2
24. Protein kinase CK2 α′ is induced by serum as a delayed early gene and cooperates with Ha-ras in cell transformation of primary embryo fibroblasts
25. Isolation, sequencing and disruption of the yeast CkA2 gene: Casein kinase II is essential for viability in Saccharomyces cerevisiae
26. Expression and localization of epitope-tagged protein kinase CK2
27. Casein kinase 2: An "eminence grise" in cellular regulation?
28. A historical view of protein kinase CK2
29. Protein kinase CK2 ("casein kinase-2") and its implication in cell division and proliferation
30. Protein kinase CK2 mutants defective in substrate recognition
31. Mutational analysis of residues implicated in the interaction between protein kinase CK2 and peptide substrates
32. A multifunctional network of basic residues confers unique properties to protein kinase CK2
33. Cooperative modulation of protein kinase CK2 by separate domains of its regulatory β subunit
34. Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ("casein kinase 2")
35. Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
36. Casein kinase 2α-induced murine lymphoma: Relation to Teilleriosis in cattle
37. Inhibition of phosphorylase kinase, and tyrosine protein kinase activities by quercetin
38. Halogenated benzimidazoles and benzotriazoles as selective inhibitors of protein kinases CKI and CKII from Saccharomyces cerevisiae and other sources
39. Protein kinase CK2 signal in neoplasia
40. Strategies toward the design of novel and selective protein tyrosine kinase inhibitors
41. Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor
42. Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription
43. Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties