Targeting a binding pocket within the trimer-of-hairpins: Small-molecule inhibition of viral fusion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 42, 2004, Pages 15046-15051

  Cianci, Christopher ^a   Langley, David R ^a   Dischino, Douglas D ^a   Sun, Yaxiong ^a,c   Yu, Kuo Long ^a,d   Stanley, Anne ^b   Roach, Julia ^a   Li, Zhufang ^a   Dalterio, Richard ^a   Colonno, Richard ^a   Meanwell, Nicholas A ^a   Krystal, Mark ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^c AMGEN INC   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BMS 356188; BMS 433771; IODINE 125; PROTEIN INHIBITOR; RFI 641; TRIMERIC CLASS 1 VIRUS FUSION PROTEIN; UNCLASSIFIED DRUG; VIRUS FUSION PROTEIN; VIRUS FUSION PROTEIN INHIBITOR;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; DRUG PROTEIN BINDING; DRUG STRUCTURE; FEASIBILITY STUDY; HYDROPHOBICITY; MOLECULAR WEIGHT; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN DOMAIN; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; VIRUS INHIBITION;

AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; BENZIMIDAZOLES; BINDING SITES; MEMBRANE FUSION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOTOAFFINITY LABELS; PROTEIN CONFORMATION; RESPIRATORY SYNCYTIAL VIRUSES; VIRAL FUSION PROTEINS;

PNEUMOVIRUS; RESPIRATORY SYNCYTIAL VIRUS; RNA VIRUSES;

EID: 6344229213     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0406696101     Document Type: Article

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