A salt bridge between an N-terminal coiled coil of gp41 and an antiviral agent targeted to the gp41 core is important for anti-HIV-1 activity

Biochemical and Biophysical Research Communications

Volumn 270, Issue 1, 2000, Pages 153-157

  Jiang, Shibo ^a   Debnath, Asim K ^a  

^a NEW YORK BLOOD CENTER   (United States)

Author keywords

Anti HIV 1 activity; Antiviral agent; Coiled coil; gp41; HIV 1; Salt bridge

Indexed keywords

ACID; ANTIVIRUS AGENT; ASPARAGINE; GLYCOPROTEIN GP 41; LYSINE; VIRUS GLYCOPROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL MEMBRANE; COMPUTER MODEL; CONTROLLED STUDY; DRUG ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT; TARGET CELL;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0034595078     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.2411     Document Type: Article

References (25)

1. Moore J. P., Trkola A., Dragic T. Curr. Opin. Immunol. 9:1997;551-562.
2. Gallaher W. R., Ball J. M., Garry R. F., Griffin M. C., Montelaro R. C. AIDS Res. Hum. Retroviruses. 5:1989;431-440.
3. Lu M., Blacklow S. C., Kim P. S. Nat. Struct. Biol. 2:1995;1075-1082.
4. Chan D. C., Fass D., Berger J. M., Kim P. S. Cell. 89:1997;263-273.
5. Weissenhorn W., Dessen A., Harrison S. C., Skehel J. J., Wiley D. C. Nature. 387:1997;426-428.
6. Tan K., Liu J., Wang J., Shen S., Liu M. Proc. Natl. Acad. Sci. 94:1997;12303-12308.
7. Jiang S., Lin K., Lu M. J. Virol. 72:1998;10213-10217.
8. Jiang S., Lin K., Strick N., Neurath A. R. Nature. 365:1993;113.
9. Wild C. T., Shugars D. C., Greenwell T. K., McDanal C. B., Matthews T. J. Proc. Natl. Acad. Sci. USA. 91:1994;9770-9774.
10. Furuta R., Wild C. T., Weng Y., Weiss C. D. Nat. Struct. Biol. 5:1998;276-279.
11. Kilby J. M., Hopkins S., Venetta T. M., DiMassimo B., Cloud G. A., Lee J. Y., Alldredge L., Hunter E., Lambert D., Bolognesi D., Matthews T., Johnson M. R., Nowak M. A., Shaw G. M., Saag M. S. Nature Med. 4:1998;1302-1307.
12. Chan D. C., Chutkowski C. T., Kim P. S. Proc. Natl. Acad. Sci. USA. 95:1998;15613-15617.
13. Eckert D. M., Malashkevich V. N., Hong L. H., Carr P. A., Kim P. S. Cell. 99:1999;103-115.
14. Ferrer M., Kapoor T. M., Strassmaier T., Weissenhorn W., Skehel J. J., Oprian D., Schreiber S. L., Wiley D. C., Harrison S. C. Nat. Struct. Biol. 6:1999;953-960.
15. Jiang S., Debnath A. K. Biochem. Biophys. Res. Commun. 2000.
16. Jiang S., Lin K., Zhang L., Debnath A. K. J. Virol. Methods. 80:1999;85-96.
17. Debnath A. K., Radigan L., Jiang S. J. Med. Chem. 42:1999;3209.
18. Chou T.-C. Chou T.-C., Rideout D. C. Synergism and Anatagonism in Chemotherpy. 1991;61-102 Academic Press, San Diego.
19. DesJarlais R. L., Sheridan R. P., Seibel G. L., Dixon J. S., Kuntz I. D., Venkataraghavan R. J. Med. Chem. 31:1988;722-729.
20. Shoichet B. K., Bodian D. L., Kuntz I. D. J. Comp. Chem. 13:1992;380-397.
21. SYBYL 6.5, 1998, 1699 South Hanley Road, St. Louis, MO, 63144, USA, Tripos Associates, Inc.
22. CrystalEyes, 1999, 2171 East Francisco Blvd. San Rafel, CA, 94901, USA, Stereographic Corp.
23. Pearlman, R. S. CONCORD 4.0 User's Manual, 1998, 1699 South Hanley Road, St. Louis, MO, 63144, USA, Tripos Associates, Inc.
24. Gschwend D. A., Sirawaraporn W., Santi D. V., Kuntz I. D. Proteins. 29:1997;59-67.
25. Korber B., Kuiken C., Foley B., Hahn B., McCutchan F., Mellors J., Sodroski J. Human Retroviruses and AIDS 1998. 1998;Los Alamos Laboratory, Los Alamos. p. I-1.