Inhibition of respiratory syncytial virus by a new class of chemotherapeutic agents

Drugs of the Future

Volumn 25, Issue 3, 2000, Pages 287-294

  Aulabaugh, Ann ^a   Ding, Wei dong ^a   Ellestad, George A ^a   Gazumyan, Anna ^a   Hess, Cynthia D ^a   Krishnamurthy, Girija ^a   Mitsner, Boris ^a   Zaccardi, Joe ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ANTIVIRUS AGENT; CL 387626; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TARGETING; NONHUMAN; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0034102408     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2000.025.03.572014     Document Type: Review

References (34)

1. Hall, C.B. Respiratory syncytial virus. In: Textbook of Pediatric Infectious Diseases, Third Edition. Feigin, R.D., Cherry, J.D. (Eds.). Saunders: Philadelphia 1992, 1633-56.
2. Hall, C.B. Respiratory syncytial virus: A continuing culprit and conundrum. J Pediatr 1999, 135: S2-7.
3. Parvez, F.M., Jarvis, W.R. Nosocomial infections in the nursery. Semin Pediatr Infect Dis 1999, 10: 119-29.
4. Cabrera, A.G., Ligon, B.L., Stein, F. Pathogenic organisms associated with asthma in children treated in the intensive care unit. Semin Pediatr Infect Dis 1999, 10: 232-8.
5. De Clercq, E. Perspectives for the chemotherapy of respiratory syncytial virus (RSV) infections. Int J Antimicrob Agents 1996, 7: 193-202.
6. Hall, C.B., McBride, J.T., Walsh, E.E. et al. Aerosolized ribavirin treatment of infants with respiratory syncytial virus infection. N Engl J Med 1983, 308: 1443-7.
7. Woods, J.M., Marr, C.L.P., Penn, C.R. Inhibition of respiratory syncytial virus replication in vitro by a pyrazole dicarboxamide analogue of ribavirin. Antiviral Chem Chemother 1994, 5: 340-3.
8. Zamorski, M. Ribavirin for lower respiratory tract infection. J Fam Pract 1996, 43: 5536-7.
9. Lewisohn, D.M., Bowden, R.A., Mattson, D., Crawford, S.W. Phase I study of intravenous ribavirin treatment of respiratory syncytial virus pneumonia after marrow transplantation. Antimicrob Agents Chemother 1996, 40: 2555-7.
10. Long, C.E., Voter, K.Z., Barker, W.H., Hall, C.B. Long term follow-up of children hospitalized with respiratory syncytial virus lower respiratory tract infection and randomly treated with ribavirin or placebo. Pediatr Infect Dis J 1997, 16: 1023-8.
11. Wyde, P.R. Mini-review: Respiratory syncytial virus (RSV) disease and prospects for its control. Antiviral Res 1998, 39: 63-79.
12. Kling, J. Restoring magic to the bullets. Mod Drug Discov 1999, 33-45.
13. Johnson, S., Oliver, C., Prince, G.A. et al. Development of a humanized monoclonal antibody (MEDI-493) with a potent in vitro and in vivo activity against respiratory syncytial virus. J Infect Dis 1997, 176: 1215-24.
14. Prince, G.A. Respiratory syncytial virus antiviral agents. Exp Opin Ther Patents 1999, 9: 753-62.
15. Anderson, K., Stott, E.J., Wertz, G.W. Intracellular processing of the human respiratory syncytial virus fusion glycoprotein: Amino acid substitutions affecting folding, transport and cleavage. J Gen Virol 1992, 73: 1177-88.
16. Baker, K.A., Dutch, R.E., Lamb, R.A., Jardetzky, T.S. Structural basis for paramyxovirus-mediated membrane fusion. Mol Cell 1999, 3: 309-19.
17. Singh, M., Berger, B., Kim, P.S. LearnCoil-VMF: Computational evidence for coiled-coil-like motifs in many viral membrane-fusion proteins. J Mol Biol 1999, 290: 1031-41.
18. Turner, B.G., Summers, M.F. Structural biology of HIV. J Mol Biol 1999, 285: 1-32.
19. Caffrey, M., Cai, M., Kaufman, J. et al. Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41. EMBO J 1998, 17: 4572-84.
20. Epand, R.F., Macosko, J.C., Russell, C.J., Shin, Y-K., Epand, R.M. The ectodomain of HA2 of influenza virus promotes rapid pH dependent membrane fusion. J Mol Biol 1999, 286: 489-503.
21. Ben-Efraim, I., Kliger, Y., Hermesh, C., Shai, Y. Membrane-induced step in the activation of Sendai virus fusion protein. J Mol Biol 1999, 285: 609-25.
22. Arumugham, R., Seid, R.C. Jr., Doyle, S., Hildreth, S.W., Paradiso, P.R. Fatty acid acylation of the fusion glycoprotein of human respiratory syncytial virus. J Biol Chem 1989, 264: 10339-42.
23. Michielin, O., Vergeres, G., Ramsden, J.J. Myristoylation-induced compaction of a membrane-binding protein. J Am Chem Soc 1999, 121: 6523-6.
24. Krusat, T., Streckert, H.-J. Heparin-dependent attachment of respiratory syncytial virus (RSV) to host cells. Arch Virol 1997, 142: 1247-54.
25. Feldman, S.A., Hendry, R.M., Beeler, J.A. Identification of a linear heparin binding domain for human respiratory syncytial virus attachment glycoprotein G. J Virol 1999, 73: 6610-7.
26. Karron, R.A., Buonagurio, D.A., Georgiu, A.F. et al. Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: Clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant. Proc Natl Acad Sci USA 1997, 94: 13961-6.
27. Haywood, A.M. Virus receptors: Binding, adhesion strengthening, and changes in viral structure. J Virol 1994, 68: 1-5.
28. Barnard, D.L., Hill, C.L., Gage, T. et al. Potent inhibition of respiratory syncytial virus by polyoxometalates of several structural classes. Antiviral Res 1997, 34: 27-37.
29. Luscher-Mattli, M., Gluck, R. Dextran sulfate inhibits the fusion of influenza virus with model membranes, and suppresses influenza virus replication in vivo. Antiviral Res 1990, 14: 39-50.
30. Hosoya, M., Balzarini, J., Shigeta, S., De Clercq, E. Differential inhibitory effects of sulfated polysaccharides and polymers on the replication of various myxoviruses and retroviruses, depending on the composition of the target amino acid sequences of the viral envelope glycoproteins. Antimicrob Agents Chemother 1991, 35: 2515-20.
31. Lambert, D.M., Barney, S., Lambert, A.L. et al. Peptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. Proc Natl Acad Sci USA 1996, 93: 2186-91.
32. Ding W-D., Mitsner, B., Krishnamurthy, G. et al. Novel and specific respiratory syncytial virus inhibitors that target virus fusion. J Med Chem 1998, 41: 2671-5.
33. Wyde, P.R., Moore-Poveda, D.K., O'Hara, B., Ding, W-D., Mitsner, B., Gilbert, B.E. CL387626 exhibits marked and unusual antiviral activity against respiratory syncytial virus in tissue culture and in cotton rats. Antiviral Res 1998, 38: 31-42.
34. Unpublished results from Wyeth-Ayerst Research Laboratories.