메뉴 건너뛰기




Volumn 46, Issue 5, 2009, Pages 748-757

PPARγ enhances IFNγ-mediated transcription and rescues the TGFβ antagonism by stimulating CIITA in vascular smooth muscle cells

Author keywords

Atherogenesis; CIITA; Collagen type I; IFN ; MHC II; PPAR ; Protein degradation; TGF ; Transcriptional regulation

Indexed keywords

COLLAGEN TYPE 1; GAMMA INTERFERON; LUCIFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSFORMING GROWTH FACTOR BETA; MHC CLASS II TRANSACTIVATOR PROTEIN; NUCLEAR PROTEIN; TRANSACTIVATOR PROTEIN;

EID: 63349106348     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2009.01.011     Document Type: Article
Times cited : (16)

References (39)
  • 1
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Nature 420 6917 (2002 Dec 19-26) 868-874
    • (2002) Nature , vol.420 , Issue.6917 , pp. 868-874
    • Libby, P.1
  • 2
    • 0021929537 scopus 로고
    • Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis
    • Jonasson L., Holm J., Skalli O., Gabbiani G., and Hansson G.K. Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis. J. Clin. Invest. 76 1 (1985 Jul) 125-131
    • (1985) J. Clin. Invest. , vol.76 , Issue.1 , pp. 125-131
    • Jonasson, L.1    Holm, J.2    Skalli, O.3    Gabbiani, G.4    Hansson, G.K.5
  • 3
    • 0027725153 scopus 로고
    • Type I collagen gene expression in human atherosclerosis. Localization to specific plaque regions
    • Rekhter M.D., Zhang K., Narayanan A.S., Phan S., Schork M.A., and Gordon D. Type I collagen gene expression in human atherosclerosis. Localization to specific plaque regions. Am. J. Pathol. 143 6 (1993 Dec) 1634-1648
    • (1993) Am. J. Pathol. , vol.143 , Issue.6 , pp. 1634-1648
    • Rekhter, M.D.1    Zhang, K.2    Narayanan, A.S.3    Phan, S.4    Schork, M.A.5    Gordon, D.6
  • 4
    • 33645294156 scopus 로고    scopus 로고
    • Interferon-gamma induces major histocompatibility class II transactivator (CIITA), which mediates collagen repression and major histocompatibility class II activation by human aortic smooth muscle cells
    • Buttice G., Miller J., Wang L., and Smith B.D. Interferon-gamma induces major histocompatibility class II transactivator (CIITA), which mediates collagen repression and major histocompatibility class II activation by human aortic smooth muscle cells. Circ. Res. 98 4 (2006 Mar 3) 472-479
    • (2006) Circ. Res. , vol.98 , Issue.4 , pp. 472-479
    • Buttice, G.1    Miller, J.2    Wang, L.3    Smith, B.D.4
  • 5
    • 0028373703 scopus 로고
    • The role of lymphocytes in the progression of interstitial disease
    • Strutz F., and Neilson E.G. The role of lymphocytes in the progression of interstitial disease. Kidney Inter., Suppl. 45 (1994 Feb) S106-S110
    • (1994) Kidney Inter., Suppl. , vol.45
    • Strutz, F.1    Neilson, E.G.2
  • 6
    • 4944225950 scopus 로고    scopus 로고
    • Major histocompatibility class II transactivator (CIITA) mediates repression of collagen (COL1A2) transcription by interferon gamma (IFN-gamma)
    • Xu Y., Wang L., Buttice G., Sengupta P.K., and Smith B.D. Major histocompatibility class II transactivator (CIITA) mediates repression of collagen (COL1A2) transcription by interferon gamma (IFN-gamma). J. Biol. Chem. 279 40 (2004 Oct 1) 41319-41332
    • (2004) J. Biol. Chem. , vol.279 , Issue.40 , pp. 41319-41332
    • Xu, Y.1    Wang, L.2    Buttice, G.3    Sengupta, P.K.4    Smith, B.D.5
  • 7
    • 0035132330 scopus 로고    scopus 로고
    • PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
    • Chawla A., Barak Y., Nagy L., Liao D., Tontonoz P., and Evans R.M. PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat. Med. 7 1 (2001 Jan) 48-52
    • (2001) Nat. Med. , vol.7 , Issue.1 , pp. 48-52
    • Chawla, A.1    Barak, Y.2    Nagy, L.3    Liao, D.4    Tontonoz, P.5    Evans, R.M.6
  • 8
    • 28844502262 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma suppresses proximal alpha1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells
    • Yavrom S., Chen L., Xiong S., Wang J., Rippe R.A., and Tsukamoto H. Peroxisome proliferator-activated receptor gamma suppresses proximal alpha1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells. J. Biol. Chem. 280 49 (2005 Dec 9) 40650-40659
    • (2005) J. Biol. Chem. , vol.280 , Issue.49 , pp. 40650-40659
    • Yavrom, S.1    Chen, L.2    Xiong, S.3    Wang, J.4    Rippe, R.A.5    Tsukamoto, H.6
  • 9
    • 0033864582 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
    • Li A.C., Brown K.K., Silvestre M.J., Willson T.M., Palinski W., and Glass C.K. Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. J. Clin. Invest. 106 4 (2000 Aug) 523-531
    • (2000) J. Clin. Invest. , vol.106 , Issue.4 , pp. 523-531
    • Li, A.C.1    Brown, K.K.2    Silvestre, M.J.3    Willson, T.M.4    Palinski, W.5    Glass, C.K.6
  • 11
    • 34548835225 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma interacts with CIITA x RFX5 complex to repress type I collagen gene expression
    • Xu Y., Farmer S.R., and Smith B.D. Peroxisome proliferator-activated receptor gamma interacts with CIITA x RFX5 complex to repress type I collagen gene expression. J. Biol. Chem. 282 36 (2007 Sep 7) 26046-26056
    • (2007) J. Biol. Chem. , vol.282 , Issue.36 , pp. 26046-26056
    • Xu, Y.1    Farmer, S.R.2    Smith, B.D.3
  • 12
    • 0032908350 scopus 로고    scopus 로고
    • Two distinct gamma interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor beta
    • Piskurich J.F., Linhoff M.W., Wang Y., and Ting J.P. Two distinct gamma interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor beta. Mol. Cell. Biol. 19 1 (1999 Jan) 431-440
    • (1999) Mol. Cell. Biol. , vol.19 , Issue.1 , pp. 431-440
    • Piskurich, J.F.1    Linhoff, M.W.2    Wang, Y.3    Ting, J.P.4
  • 13
    • 33748493395 scopus 로고    scopus 로고
    • Epigenetic regulation during B cell differentiation controls CIITA promoter accessibility
    • Green M.R., Yoon H., and Boss J.M. Epigenetic regulation during B cell differentiation controls CIITA promoter accessibility. J. Immunol. 177 6 (2006 Sep 15) 3865-3873
    • (2006) J. Immunol. , vol.177 , Issue.6 , pp. 3865-3873
    • Green, M.R.1    Yoon, H.2    Boss, J.M.3
  • 14
    • 34047156083 scopus 로고    scopus 로고
    • TGF-beta and atherosclerosis in man
    • Grainger D.J. TGF-beta and atherosclerosis in man. Cardiovasc. Res. 74 2 (2007 May 1) 213-222
    • (2007) Cardiovasc. Res. , vol.74 , Issue.2 , pp. 213-222
    • Grainger, D.J.1
  • 15
    • 33745571976 scopus 로고    scopus 로고
    • The immune response in atherosclerosis: a double-edged sword
    • Hansson G.K., and Libby P. The immune response in atherosclerosis: a double-edged sword. Nat. Rev., Immunol. 6 7 (2006 Jul) 508-519
    • (2006) Nat. Rev., Immunol. , vol.6 , Issue.7 , pp. 508-519
    • Hansson, G.K.1    Libby, P.2
  • 16
    • 1442333284 scopus 로고    scopus 로고
    • Atherosclerosis and extracellular matrix
    • Katsuda S., and Kaji T. Atherosclerosis and extracellular matrix. J. Atheroscler. Thromb. 10 5 (2003) 267-274
    • (2003) J. Atheroscler. Thromb. , vol.10 , Issue.5 , pp. 267-274
    • Katsuda, S.1    Kaji, T.2
  • 17
    • 20444381299 scopus 로고    scopus 로고
    • Interferon-gamma and atherosclerosis: pro- or anti-atherogenic?
    • Harvey E.J., and Ramji D.P. Interferon-gamma and atherosclerosis: pro- or anti-atherogenic?. Cardiovasc. Res. 67 1 (2005 Jul 1) 11-20
    • (2005) Cardiovasc. Res. , vol.67 , Issue.1 , pp. 11-20
    • Harvey, E.J.1    Ramji, D.P.2
  • 18
    • 0242384852 scopus 로고    scopus 로고
    • Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3
    • Higashi K., Inagaki Y., Fujimori K., Nakao A., Kaneko H., and Nakatsuka I. Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3. J. Biol. Chem. 278 44 (2003 Oct 31) 43470-43479
    • (2003) J. Biol. Chem. , vol.278 , Issue.44 , pp. 43470-43479
    • Higashi, K.1    Inagaki, Y.2    Fujimori, K.3    Nakao, A.4    Kaneko, H.5    Nakatsuka, I.6
  • 19
    • 33644969133 scopus 로고    scopus 로고
    • Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects
    • Dooley S., Said H.M., Gressner A.M., Floege J., En-Nia A., and Mertens P.R. Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects. J. Biol. Chem. 281 3 (2006 Jan 20) 1784-1795
    • (2006) J. Biol. Chem. , vol.281 , Issue.3 , pp. 1784-1795
    • Dooley, S.1    Said, H.M.2    Gressner, A.M.3    Floege, J.4    En-Nia, A.5    Mertens, P.R.6
  • 20
    • 0035085720 scopus 로고    scopus 로고
    • Molecular mechanisms of TGF-(beta) antagonism by interferon (gamma) and cyclosporine A in lung fibroblasts
    • Eickelberg O., Pansky A., Koehler E., Bihl M., Tamm M., Hildebrand P., et al. Molecular mechanisms of TGF-(beta) antagonism by interferon (gamma) and cyclosporine A in lung fibroblasts. FASEB J. 15 3 (2001 Mar) 797-806
    • (2001) FASEB J. , vol.15 , Issue.3 , pp. 797-806
    • Eickelberg, O.1    Pansky, A.2    Koehler, E.3    Bihl, M.4    Tamm, M.5    Hildebrand, P.6
  • 21
    • 0035815696 scopus 로고    scopus 로고
    • Antagonistic regulation of type I collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP transcriptional coactivators
    • Ghosh A.K., Yuan W., Mori Y., Chen S., and Varga J. Antagonistic regulation of type I collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP transcriptional coactivators. J. Biol. Chem. 276 14 (2001 Apr 6) 11041-11048
    • (2001) J. Biol. Chem. , vol.276 , Issue.14 , pp. 11041-11048
    • Ghosh, A.K.1    Yuan, W.2    Mori, Y.3    Chen, S.4    Varga, J.5
  • 22
    • 0034004430 scopus 로고    scopus 로고
    • Transforming growth factor-beta mRNA and protein in hypertrophic scar tissues and fibroblasts: antagonism by IFN-alpha and IFN-gamma in vitro and in vivo
    • Tredget E.E., Wang R., Shen Q., Scott P.G., and Ghahary A. Transforming growth factor-beta mRNA and protein in hypertrophic scar tissues and fibroblasts: antagonism by IFN-alpha and IFN-gamma in vitro and in vivo. J. Interferon Cytokine Res. 20 2 (2000 Feb) 143-151
    • (2000) J. Interferon Cytokine Res. , vol.20 , Issue.2 , pp. 143-151
    • Tredget, E.E.1    Wang, R.2    Shen, Q.3    Scott, P.G.4    Ghahary, A.5
  • 23
    • 1042286477 scopus 로고    scopus 로고
    • Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosis
    • Ricote M., Valledor A.F., and Glass C.K. Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 24 2 (2004 Feb) 230-239
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , Issue.2 , pp. 230-239
    • Ricote, M.1    Valledor, A.F.2    Glass, C.K.3
  • 24
    • 0033977890 scopus 로고    scopus 로고
    • The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    • Vega R.B., Huss J.M., and Kelly D.P. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell. Biol. 20 5 (2000 Mar) 1868-1876
    • (2000) Mol. Cell. Biol. , vol.20 , Issue.5 , pp. 1868-1876
    • Vega, R.B.1    Huss, J.M.2    Kelly, D.P.3
  • 26
    • 0029905399 scopus 로고    scopus 로고
    • Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids
    • Wu Z., Bucher N.L., and Farmer S.R. Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids. Mol. Cell. Biol. 16 8 (1996 Aug) 4128-4136
    • (1996) Mol. Cell. Biol. , vol.16 , Issue.8 , pp. 4128-4136
    • Wu, Z.1    Bucher, N.L.2    Farmer, S.R.3
  • 27
    • 0028971225 scopus 로고
    • Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis
    • Wu Z., Xie Y., Bucher N.L., and Farmer S.R. Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Genes Dev. 9 19 (1995 Oct 1) 2350-2363
    • (1995) Genes Dev. , vol.9 , Issue.19 , pp. 2350-2363
    • Wu, Z.1    Xie, Y.2    Bucher, N.L.3    Farmer, S.R.4
  • 28
    • 3042681042 scopus 로고    scopus 로고
    • Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
    • Picard F., Kurtev M., Chung N., Topark-Ngarm A., Senawong T., Machado De Oliveira R., et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429 6993 (2004 Jun 17) 771-776
    • (2004) Nature , vol.429 , Issue.6993 , pp. 771-776
    • Picard, F.1    Kurtev, M.2    Chung, N.3    Topark-Ngarm, A.4    Senawong, T.5    Machado De Oliveira, R.6
  • 29
    • 0036900873 scopus 로고    scopus 로고
    • The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation
    • Fajas L., Egler V., Reiter R., Hansen J., Kristiansen K., Debril M.B., et al. The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev. Cell 3 6 (2002 Dec) 903-910
    • (2002) Dev. Cell , vol.3 , Issue.6 , pp. 903-910
    • Fajas, L.1    Egler, V.2    Reiter, R.3    Hansen, J.4    Kristiansen, K.5    Debril, M.B.6
  • 30
    • 0032589689 scopus 로고    scopus 로고
    • Activation of PPARgamma coactivator-1 through transcription factor docking
    • Puigserver P., Adelmant G., Wu Z., Fan M., Xu J., O'Malley B., et al. Activation of PPARgamma coactivator-1 through transcription factor docking. Science 286 5443 (1999 Nov 12) 1368-1371
    • (1999) Science , vol.286 , Issue.5443 , pp. 1368-1371
    • Puigserver, P.1    Adelmant, G.2    Wu, Z.3    Fan, M.4    Xu, J.5    O'Malley, B.6
  • 31
    • 0037154549 scopus 로고    scopus 로고
    • PPARgamma but not PPARalpha ligands are potent repressors of major histocompatibility complex class II induction in atheroma-associated cells
    • Kwak B.R., Myit S., Mulhaupt F., Veillard N., Rufer N., Roosnek E., et al. PPARgamma but not PPARalpha ligands are potent repressors of major histocompatibility complex class II induction in atheroma-associated cells. Circ. Res. 90 3 (2002 Feb 22) 356-362
    • (2002) Circ. Res. , vol.90 , Issue.3 , pp. 356-362
    • Kwak, B.R.1    Myit, S.2    Mulhaupt, F.3    Veillard, N.4    Rufer, N.5    Roosnek, E.6
  • 32
    • 33748612720 scopus 로고    scopus 로고
    • 15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism
    • Willermain F., Dulku S., Gonzalez N.S., Blero D., Driessens G., De Graef C., et al. 15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism. Prostaglandins Other Lipid Mediat. 80 3-4 (2006 Sep) 136-143
    • (2006) Prostaglandins Other Lipid Mediat. , vol.80 , Issue.3-4 , pp. 136-143
    • Willermain, F.1    Dulku, S.2    Gonzalez, N.S.3    Blero, D.4    Driessens, G.5    De Graef, C.6
  • 33
    • 0028080019 scopus 로고
    • Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet
    • Fyfe A.I., Qiao J.H., and Lusis A.J. Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet. J. Clin. Invest. 94 6 (1994 Dec) 2516-2520
    • (1994) J. Clin. Invest. , vol.94 , Issue.6 , pp. 2516-2520
    • Fyfe, A.I.1    Qiao, J.H.2    Lusis, A.J.3
  • 34
    • 0028895573 scopus 로고
    • Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis
    • Palinski W., Miller E., and Witztum J.L. Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis. Proc. Natl. Acad. Sci. U. S. A. 92 3 (1995 Jan 31) 821-825
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , Issue.3 , pp. 821-825
    • Palinski, W.1    Miller, E.2    Witztum, J.L.3
  • 35
    • 14844346470 scopus 로고    scopus 로고
    • Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis
    • Zhou X., Robertson A.K., Rudling M., Parini P., and Hansson G.K. Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis. Circ. Res. 96 4 (2005 Mar 4) 427-434
    • (2005) Circ. Res. , vol.96 , Issue.4 , pp. 427-434
    • Zhou, X.1    Robertson, A.K.2    Rudling, M.3    Parini, P.4    Hansson, G.K.5
  • 36
    • 4043114091 scopus 로고    scopus 로고
    • Timing affects the efficacy of LDL immunization on atherosclerotic lesions in apo E (-/-) mice
    • Chyu K.Y., Reyes O.S., Zhao X., Yano J., Dimayuga P., Nilsson J., et al. Timing affects the efficacy of LDL immunization on atherosclerotic lesions in apo E (-/-) mice. Atherosclerosis 176 1 (2004 Sep) 27-35
    • (2004) Atherosclerosis , vol.176 , Issue.1 , pp. 27-35
    • Chyu, K.Y.1    Reyes, O.S.2    Zhao, X.3    Yano, J.4    Dimayuga, P.5    Nilsson, J.6
  • 37
    • 0037155780 scopus 로고    scopus 로고
    • Decreased nitric oxide synthesis in human endothelial cells cultured on type I collagen
    • Gonzalez-Santiago L., Lopez-Ongil S., Rodriguez-Puyol M., and Rodriguez-Puyol D. Decreased nitric oxide synthesis in human endothelial cells cultured on type I collagen. Circ. Res. 90 5 (2002 Mar 22) 539-545
    • (2002) Circ. Res. , vol.90 , Issue.5 , pp. 539-545
    • Gonzalez-Santiago, L.1    Lopez-Ongil, S.2    Rodriguez-Puyol, M.3    Rodriguez-Puyol, D.4
  • 38
    • 0031028794 scopus 로고    scopus 로고
    • Inhibition of collagen synthesis, smooth muscle cell proliferation, and injury-induced intimal hyperplasia by halofuginone
    • Nagler A., Miao H.Q., Aingorn H., Pines M., Genina O., and Vlodavsky I. Inhibition of collagen synthesis, smooth muscle cell proliferation, and injury-induced intimal hyperplasia by halofuginone. Arterioscler. Thromb. Vasc. Biol. 17 1 (1997 Jan) 194-202
    • (1997) Arterioscler. Thromb. Vasc. Biol. , vol.17 , Issue.1 , pp. 194-202
    • Nagler, A.1    Miao, H.Q.2    Aingorn, H.3    Pines, M.4    Genina, O.5    Vlodavsky, I.6
  • 39
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen S.E., and Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N. Engl. J. Med. 356 24 (2007 Jun 14) 2457-2471
    • (2007) N. Engl. J. Med. , vol.356 , Issue.24 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.