Portal vein glucose sensors do not play a major role in modulating physiological responses to insulin-induced hypoglycemia in humans

Diabetes

Volumn 58, Issue 1, 2009, Pages 194-202

  Rossetti, Paolo ^a   Porcellati, Francesca ^a   Lucidi, Paola ^a   Ricci, Natalia Busciantella ^a   Candeloro, Paola ^a   Cioli, Patrizia ^a   Santeusanio, Fausto ^a   Bolli, Geremia B ^a   Fanelli, Carmine G ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; C PEPTIDE; GLUCOSE; GROWTH HORMONE; HYDROCORTISONE; INSULIN; NORADRENALIN; PANCREAS POLYPEPTIDE; PLACEBO; ANTIDIABETIC AGENT; GLUCAGON; GLYCEROL; LACTIC ACID DERIVATIVE;

ADULT; ARTICLE; COGNITION; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE INTAKE; HUMAN; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; MALE; PORTAL VEIN; PRIORITY JOURNAL; SCORING SYSTEM; BLOOD; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; DRUG EFFECT; METABOLISM; METHODOLOGY; MONITORING; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADULT; BLOOD GLUCOSE; COGNITION; DOUBLE-BLIND METHOD; EPINEPHRINE; FEMALE; GLUCAGON; GLUCOSE; GLYCEROL; HUMANS; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; LACTATES; MALE; MONITORING, PHYSIOLOGIC; NOREPINEPHRINE; PORTAL VEIN;

EID: 63249111745     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-0641     Document Type: Article

References (53)

1. Niijima A: Afferent impulse discharges from glucoreceptors in the liver of the guinea pig. Ann N Y Acad Sci 157:690-700, 1969
2. Pagliassotti MJ, Holste LC, Moore MC, Neal DW, Cherrington AD: Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J Clin Invest 97:81-91, 1996
3. Moore MC, Cardin S, Edgerton DS, Farmer B, Neal DW, Lautz M, Cherrington AD: Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion. Am, J Physiol Endocrinol Metab 286:E226-E233, 2004
4. Zangeneh F, Basu R, Shah P, Arora P, Camilleri M, Rizza RA: Enteral infusion of glucose at rates approximating EGP enhances glucose disposal but does not cause hypoglycemia. Am J Physiol Endocrinol Metab 285:E280-E286, 2003
5. Heptulla RA, Tamborlane WV, Ma TY, Rife F, Sherwin RS: Oral glucose augments the counterregulatory hormone response during insulin-induced hypoglycemia in humans. J Clin Endocrinol Metab 86:645-648, 2001
6. Smith D, Pernet A, Reid H, Bingham E, Rosenthal JM, Macdonald IA, Umpleby AM, Amiel SA: The role of hepatic portal glucose sensing in modulating responses to hypoglycaemia in man. Diabetologia 45:1416-1424, 2002
7. Ertl AC, Mann S, Richardson A, Briscoe VJ, Blair HB, Tate DB, Davis SN: Effects of oral carbohydrate on autonomic nervous system counterregula-tory responses during hyper-insulinemic hypoglycemia and euglycemia. Am J Physiol Endocrinol Metab 295:E618-E625, 2008
8. Niijima A: The effect of D-glucose on the firing rate of glucose-sensitive vagal afferents in the liver in comparison with the effect of 2-deoxy-D- glucose. J Auton Nerv Syst 10:255-260, 1984
9. Burcelin R, Da Costa A, Drucker D, Thorens B: Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor. Diabetes 50:1720-1728, 2001
10. Schmitt M: Influences of hepatic portal receptors on hypothalamic feeding and satiety centers. Am J Physiol 225:1089-1095, 1973
11. Burcelin R, Dolci W, Thorens B: Glucose sensing by the hepatoportal sensor is GLUT2-dependent: in vivo analysis in GLUT2-null mice. Diabetes 49:1643-1648, 2000
12. Thorens B: GLUT2 in pancreatic and extra-pancreatic gluco- detection(Review). Mol Membr Biol 18:265-273, 2001
13. Galassetti P, Chu CA, Neal DW, Reed GW, Wasserman DH, Cherrington AD: A negative arterial-portal venous glucose gradient increases net hepatic glucose uptake in euglycemic dogs. Am, J Physiol 277:E126-E134, 1999
14. Donovan CM, Halter JB, Bergman RN: Importance of hepatic glucorecep-tors in sympathoadrenal response to hypoglycemia. Diabetes 40:155-158, 1991
15. Hamilton-Wessler M, Bergman RN, Halter JB, Watanabe RM, Donovan CM: The role of liver glucosensors in the integrated sympathetic response induced by deep hypoglycemia in dogs. Diabetes 43:1052-1060, 1994
16. Cherrington AD: Central versus peripheral glucose sensing and the response to hypoglycemia. Diabetes 57:1158-1159, 2008
17. Biggers DW, Myers SR, Neal D, Stinson R, Cooper NB, Jaspan JB, Williams PE, Cherrington AD, Frizzell RT: Role of brain in counterregulation of insulin-induced hypoglycemia in dogs. Diabetes 38:7-16, 1989
18. Frizzell RT, Jones EM, Davis SN, Biggers DW, Myers SR, Connolly CC, Neal DW, Jaspan JB, Cherrington AD: Counterregulation during hypoglycemia is directed by widespread brain regions. Diabetes 42:1253-1261, 1993
19. Borg WP, Sherwin RS, During MJ, Borg MA, Shulman GI: Local ventrome-dial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes 1995 44:180-184, 1995
20. Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI: Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. J Clin Invest 99:361-536, 1997
21. Smith D, Amiel SA: The anatomy of the human hypoglycaemia sensor. Diabetes Nutr Metab 15:316-318, 2002
22. McCrimmon R: The mechanisms that underlie glucose sensing during hypoglycaemia in diabetes. Diabet Med 25:513-522, 2008
23. Donovan CM, Hamilton-Wessler M, Halter JB, Bergman RN: Primacy of liver glucosensors in the sympathetic response to progressive hypoglycemia. Proc Natl Acad SciUSA91:2863-2867, 1994
24. Hevener AL, Bergman RN, Donovan CM: Novel glucosensor for hypogly-cemic detection localized to the portal vein. Diabetes 46:1521-1525, 1997
25. Hevener AL, Bergman RN, Donovan CM: Hypoglycemic detection does not occur in the hepatic artery or liver: findings consistent with a portal vein glucosensor locus. Diabetes 50:399-403, 2001
26. Saberi M, Bohland M, Donovan CM: The locus for hypoglycemic detection shifts with the rate of fall in glycemia: the role of portal-superior mesenteric vein glucose sensing. Diabetes 57:1380-1386, 2008
27. Fanelli CG, Pampanelli S, Porcellati F, Bartocci L, Scionti L, Rossetti P, Bolli GB: Rate of fall of blood glucose and physiological responses of counterregulatory hormones, clinical symptoms and cognitive function to hypoglycaemia in type I diabetes mellitus in the postprandial state. Diabetologia 46:53-64, 2003
28. Matveyenko AV, Donovan CM: Metabolic sensors mediate hypoglycemic detection at the portal vein. Diabetes 55:1276-1282, 2006
29. McGuire E, Helderman J, Tobin J, Andres R, Berman M: Effects of arterial venous sampling on analysis of glucose kinetics in man. J Appl Physiol 41:565-573, 1976
30. Mitrakou A, Ryan C, Veneman T, Mokan M, Jenssen T, Kiss I, Durrant J, Cryer P, Gerich J: Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am J Physiol 260:E67-E74, 1991
31. Cryer PE: Symptoms of hypoglycemia, thresholds for their occurrence, and hypoglycemia unawareness. Endocrinol Metab Clin North Am 28:495-500, 1999
32. Boll T, Barth J: Neuropsychology of brain damage. In Handbook of Clinical Neuropsychology. Filskov S, Boll T, Eds. New York, Wiley, 1981, p. 418-452
33. Lezak MD, Howieson DB, Loring DW, Hannay HJ, Fischer JS: Neuropsy-chological Assessment. 4th ed. New York, Oxford University Press, 2004, p.429-550
34. Wechsler D: Manual of the Wechsler Adult Intelligence Scale-Revised. New York, The Psychological Corporation Limited, 1981
35. Golden C: Stroop Color and Word Test. Chicago, Stoelting, 1978
36. Gronwall DMA: Paced auditory serial-addition task: a measure of recovery from concussion. Percept Mot Skills 44:367-373, 1977
37. Fanelli CG, De Feo P, Porcellati F, Perriello G, Torlone E, Santeusanio F,
38. Brunetti P, Bolli GB: Adrenergic mechanisms contribute to the late phase of hypoglycemic glucose counterregulation in humans by stimulating lipolysis. J Clin Invest 89:2005-2013, 1992
39. Winer BJ, Brown DR, Michels KM: Statistical Principles in Experimental Design. 3rd ed. New York, McGraw Hill, 1991, p. 497-582
40. Holland BS, Copenhaver M: Improved Bonferroni type multiple testing procedures. Psychol Bull 104:145-148, 1988
41. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, Mori K, Komatsu Y, Usui T, Shimatsu A, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K: Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 85:4908-4911, 2000
42. Van der Lely AJ, Tschop M, Heiman ML, Ghigo E: Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25:426-457, 2004
43. Lucidi P, Murdolo G, Di Loreto C, De Cicco A, Parlanti N, Fanelli C, Santeusanio F, Bolli GB, De Feo P: Ghrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemia. Diabetes 51:2911-2914, 2002
44. Broglio F, Gottero C, Prodam F, Destefanis S, Gauna C, Me E, Riganti F, Vivenza D, Rapa A, Martina V, Arvat E, Bona G, van der Lely AJ, Ghigo E: Ghrelin secretion is inhibited by glucose load and insulin-induced hypo-glycaemia but unaffected by glucagon and arginine in humans. Clin Endocrinol 61:503-509, 200
45. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS,
46. Ghatei MA, Bloom SR: Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86:5992, 2001
47. Nauck MA, Homberger E, Siegel EG, Allen RC, Eaton RP, Ebert R, Creutzfeldt W: Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab 63:492-498, 1986
48. Qualmann C, Nauck MA, Holst JJ, Orskov C, Creutzfeldt W: Insulinotropic actions of intravenous glucagon-like peptide-1(GLP-1)[7-36 amide]in the fasting state in healthy subjects. Acta Diabetol 32:13-16, 1995
49. Nauck MA, Heimesaat MM, Behle K, Holst JJ, Nauck MS, Ritzel R, Hüfner M, Schmiegel WH: Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. J Clin Endocrinol Metab 87:1239-1246, 2002
50. During MJ: 2003 Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med 9:1173-1179, 2003
51. Radziuk J, McDonald TJ, Rubenstein D, Dupre J: Initial splanchnic extraction of ingested glucose in normal man. Metabolism 27:657-669, 1978
52. Saccà L, Cicala M, Corso G, Ungaro B, Sherwin RS: Effect of counterregulatory hormones on kinetic response to ingested glucose in dogs. Am J Physiol 240:E465-E473, 1981
53. Petersen KF, Cline GW, Gerard DP, Magnusson I, Rothman DL, Shulman GI: Contribution of net hepatic glycogen synthesis to disposal of an oral glucose load in humans. Metabolism 50:598-601, 2001