Characterization of cellular uptake and distribution of coenzyme Q10 and vitamin E in PC12 cells

Journal of Nutritional Biochemistry

Volumn 20, Issue 5, 2009, Pages 350-357

  Saito, Yoshiro ^a,c   Fukuhara, Akiko ^a   Nishio, Keiko ^a   Hayakawa, Mieko ^a   Ogawa, Yoko ^a   Sakamoto, Hirokazu ^b   Fujii, Kenji ^b   Yoshida, Yasukazu ^b   Niki, Etsuo ^b  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b KANEKA CORPORATION   (Japan)

^c DOSHISHA UNIVERSITY   (Japan)

Author keywords

Cellular distribution; Cellular uptake; Coenzyme Q; Subcellular fractionation study; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; LIPID; UBIDECARENONE; UBIQUINOL CYTOCHROME C REDUCTASE; UBIQUINONE;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL STRAIN; CELL TRANSPORT; CELLULAR DISTRIBUTION; MICROSOME MEMBRANE; MITOCHONDRION; NONHUMAN; PHEOCHROMOCYTOMA CELL; PROTEIN LOCALIZATION; RAT;

ALPHA-TOCOPHEROL; ANIMALS; PC12 CELLS; RATS; UBIQUINONE;

RATTUS;

EID: 63249110681     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2008.04.005     Document Type: Article

References (37)

1. Chen Z.H., Yoshida Y., Saito Y., Noguchi N., and Niki E. Adaptive response induced by lipid peroxidation products in cell cultures. FEBS Lett 580 (2006) 479-483
2. Saito Y., Nishio K., Numakawa Y., Ogawa Y., Yoshida Y., Noguchi N., et al. Protective effects of 15-deoxy-Delta12,14-prostaglandin J2 against glutamate-induced cell death in primary cortical neuron cultures: induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione. J Neurochem 102 (2007) 1625-1634
3. Leonarduzzi G., Arkan M.C., Basaga H., Chiarpotto E., Sevanian A., and Poli G. Lipid oxidation products in cell signaling. Free Radic Biol Med 28 (2000) 1370-1378
4. Lenaz G., Fato R., Formiggini G., and Genova M.L. The role of coenzyme Q in mitochondrial electron transport. Mitochondrion 7 Suppl (2007) S8-S33
5. Navas P., Villalba J.M., and de Cabo R. The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion 7 Suppl (2007) S34-S40
6. Shi H., Noguchi N., and Niki E. Comparative study on dynamics of antioxidative action of alpha-tocopheryl hydroquinone, ubiquinol, and alpha-tocopherol against lipid peroxidation. Free Radic Biol Med 27 (1999) 334-346
7. Stocker R., Bowry V.W., and Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci U S A 88 (1991) 1646-1650
8. Yoshida Y., Hayakawa M., Habuchi Y., and Niki E. Evaluation of the dietary effects of coenzyme Q in vivo by the oxidative stress marker, hydroxyoctadecadienoic acid and its stereoisomer ratio. Biochim Biophys Acta 1760 (2006) 1558-1568
9. Kalen A., Norling B., Appelkvist E.L., and Dallner G. Ubiquinone biosynthesis by the microsomal fraction from rat liver. Biochim Biophys Acta 926 (1987) 70-78
10. Fernandez-Ayala D.J., Brea-Calvo G., Lopez-Lluch G., and Navas P. Coenzyme Q distribution in HL-60 human cells depends on the endomembrane system. Biochim Biophys Acta 1713 (2005) 129-137
11. Saito Y., Yoshida Y., Akazawa T., Takahashi K., and Niki E. Cell death caused by selenium deficiency and protective effect of antioxidants. J Biol Chem 278 (2003) 39428-39434
12. Piga R., Saito Y., Chen Z., Yoshida Y., and Niki E. Characterization of monochloramine toxicity on PC12 cells and protective effect of tocopherol via antioxidative function. Arch Biochem Biophys 436 (2005) 101-109
13. Piga R., Saito Y., Yoshida Y., and Niki E. Cytotoxic effects of various stressors on PC12 cells: involvement of oxidative stress and effect of antioxidants. Neurotoxicology 28 (2007) 67-75
14. Saito Y., Yoshida Y., Nishio K., Hayakawa M., and Niki E. Characterization of cellular uptake and distribution of vitamin E. Ann N Y Acad Sci 1031 (2004) 368-375
15. Horvath T.L., Diano S., Leranth C., Garcia-Segura L.M., Cowley M.A., Shanabrough M., et al. Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease. Endocrinology 144 (2003) 2757-2760
16. Shults C.W. Therapeutic role of coenzyme Q(10) in Parkinson's disease. Pharmacol Ther 107 (2005) 120-130
17. Brancato R., Schiavone N., Siano S., Lapucci A., Papucci L., Donnini M., et al. Prevention of corneal keratocyte apoptosis after argon fluoride excimer laser irradiation with the free radical scavenger ubiquinone Q10. Eur J Ophthalmol 10 (2000) 32-38
18. Ernst A., Stolzing A., Sandig G., and Grune T. Antioxidants effectively prevent oxidation-induced protein damage in OLN 93 cells. Arch Biochem Biophys 421 (2004) 54-60
19. Papucci L., Schiavone N., Witort E., Donnini M., Lapucci A., Tempestini A., et al. Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property. J Biol Chem 278 (2003) 28220-28228
20. Navas P., Fernandez-Ayala D.M., Martin S.F., Lopez-Lluch G., De Caboa R., Rodriguez-Aguilera J.C., et al. Ceramide-dependent caspase 3 activation is prevented by coenzyme Q from plasma membrane in serum-deprived cells. Free Radic Res 36 (2002) 369-374
21. Ikehara T, Kishida H. (2006) Coenzyme Q10-containing water-soluble composition and process for production thereof. International Patent disclosure No. WO 2006/134970A1.
22. Saito Y., Nishio K., Ogawa Y., Kinumi T., Yoshida Y., Masuo Y., et al. Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: involvement of hydrogen peroxide-dependent and-independent action. Free Radic Biol Med 42 (2007) 675-685
23. Imai H., Narashima K., Arai M., Sakamoto H., Chiba N., and Nakagawa Y. Suppression of leukotriene formation in RBL-2H3 cells that overexpressed phospholipid hydroperoxide glutathione peroxidase. J Biol Chem 273 (1998) 1990-1997
24. Ogasawara M., Tsuruta K., and Arao S. Flame photometric detector for thin-layer chromatography. J Chromatogr A973 (2002) 151-158
25. Kalen A., Appelkvist E.L., and Dallner G. Age-related changes in the lipid compositions of rat and human tissues. Lipids 24 (1989) 579-584
26. Lass A., and Sohal R.S. Comparisons of coenzyme Q bound to mitochondrial membrane proteins among different mammalian species. Free Radic Biol Med 27 (1999) 220-226
27. Leist M., Raab B., Maurer S., Rosick U., and Brigelius-Flohe R. Conventional cell culture media do not adequately supply cells with antioxidants and thus facilitate peroxide-induced genotoxicity. Free Radic Biol Med 21 (1996) 297-306
28. Takahashi T., Shitashige M., Okamoto T., Kishi T., and Goshima K. A novel ubiquinone reductase activity in rat cytosol. FEBS Lett 314 (1992) 331-334
29. Constantinescu A., Maguire J.J., and Packer L. Interactions between ubiquinones and vitamins in membranes and cells. Mol Aspects Med 15 Suppl (1994) s57-s65
30. Kagan V.E., Nohl H., and Quinn P.J. In: Cadenas E., and Packer L. (Eds). Coenzyme Q: its role in scavenging and generation of radicals in membranes 1 (1996), Marcel Decker Inc., New York 157-201
31. Beyer R.E., Segura-Aguilar J., Di Bernardo S., Cavazzoni M., Fato R., Fiorentini D., et al. The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems. Proc Natl Acad Sci U S A 93 (1996) 2528-2532
32. Ogawa Y, Saito Y, Nishio K, Yoshida Y, Ashida H, Niki E. γ-Tocopheryl quinone, not α-tocopheryl quinone, induces adaptive response through up-regulation of cellullar glutathione and cysteine availability via activation of ATF4. Free Radic Res [in press].
33. Siegel D., Bolton E.M., Burr J.A., Liebler D.C., and Ross D. The reduction of alpha-tocopherolquinone by human NAD(P)H:quinone oxidoreductase: the role of alpha-tocopherolhydroquinone as a cellular antioxidant. Mol Pharmacol 52 (1997) 300-305
34. Jauslin M.L., Meier T., Smith R.A., and Murphy M.P. Mitochondria-targeted antioxidants protect Friedreich ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J 17 (2003) 1972-1974
35. Tran U.C., and Clarke C.F. Endogenous synthesis of coenzyme Q in eukaryotes. Mitochondrion 7 Suppl (2007) S62-S71
36. Cocheme H.M., Kelso G.F., James A.M., Ross M.F., Trnka J., Mahendiran T., et al. Mitochondrial targeting of quinones: therapeutic implications. Mitochondrion 7 Suppl (2007) S94-S102
37. Weissig V., Boddapati S.V., Jabr L., and D'Souza G.G. Mitochondria-specific nanotechnology. Nanomed 2 (2007) 275-285