Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 8, 2009, Pages 2270-2272

  Feng, Zhiqiang ^a   Chu, Fengming ^a   Guo, Zongru ^a   Sun, Piaoyang ^b  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b Jiangsu Hengrui Medicine Co Ltd   (China)

Author keywords

Imrecoxib; Metabolites; Selective COX 2 inhibitor

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DRUG METABOLITE; IMRECOXIB; PYRROLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; INFLAMMATION; NONHUMAN; PAW EDEMA; RAT; REACTION ANALYSIS; SINGLE DRUG DOSE; STRUCTURE ANALYSIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 2 INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; HUMANS; MICE; PYRAZOLES; PYRROLES; RATS; SULFIDES; SULFONAMIDES;

EID: 63149175362     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.090     Document Type: Article

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