Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx(TM))

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 23, 2000, Pages 2683-2686

  Nicoll Griffith, Deborah A ^a   Yergey, James A ^a   Trimble, Laird A ^a   Silva, José M ^a   Li, Chun ^a   Chauret, Nathalie ^a   Gauthier, Jacques Yves ^a   Grimm, Erich ^a   Léger, Serge ^a   Roy, Patrick ^a   Thérien, Michel ^a   Wang, Zhaoyin ^a   Prasit, Peppi ^a   Zamboni, Robert ^a   Young, Robert N ^a   Brideau, Christine ^a   Chan, Chi Chung ^a   Mancini, Joseph ^a   Riendeau, Denis ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; ROFECOXIB;

ARTICLE; BIOTRANSFORMATION; DRUG GLUCURONIDATION; DRUG HYDROLYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; HUMANS; ISOENZYMES; LACTONES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; SULFONES;

EID: 0034606408     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00538-2     Document Type: Article

References (13)