Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 8, 2009, Pages 2299-2304

  Pegoraro, Stefano ^a   Lang, Martin ^a   Dreker, Tobias ^a   Kraus, Jürgen ^a   Hamm, Svetlana ^a   Meere, Cathal ^a   Feurle, Juliane ^a   Tasler, Stefan ^a   Prütting, Sylvia ^b   Kuras, Zerrin ^b   Visan, Violeta ^b   Grissmer, Stephan ^b  

^a 4SC AG   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

Autoimmune diseases; Homology model; IK 1; KV1.3; Potassium channel; vHTS

Indexed keywords

CLOTRIMAZOLE; IMMUNOSUPPRESSIVE AGENT; OXAZOLONE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL IK 1; POTASSIUM CHANNEL IK 1 BLOCKING AGENT; POTASSIUM CHANNEL KV1.3; POTASSIUM CHANNEL KV1.3 BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; HIGH THROUGHPUT SCREENING; IMMUNOSUPPRESSIVE TREATMENT; INHIBITION KINETICS; KERATINOCYTE; MOUSE; NONHUMAN; POTASSIUM TRANSPORT; SEQUENCE HOMOLOGY; T LYMPHOCYTE ACTIVATION;

ANIMALS; CALCIUM SIGNALING; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNOSUPPRESSIVE AGENTS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; KERATINOCYTES; KV1.3 POTASSIUM CHANNEL; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS;

ANIMALIA;

EID: 63149154393     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.077     Document Type: Article

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