Distinct modes of gene regulation by a cell-specific transcriptional activator

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 11, 2009, Pages 4213-4218

  Sengupta, Tanushri ^a   Cohet, Nathalie ^b   Morlé, François ^b   Bieker, James J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITÉ DE LYON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA HEMOGLOBIN STABILIZING PROTEIN; BETA GLOBIN; ERYTHROID KRUPPEL LIKE FACTOR; PROTEIN; TATA BINDING PROTEIN ASSOCIATED FACTOR; TATA BINDING PROTEIN ASSOCIATED FACTOR 9; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BETA THALASSEMIA; CELL SPECIFICITY; CONTROLLED STUDY; EMBRYO; GENE; GENE CONTROL; GENE MUTATION; GLOBIN GENE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TISSUE SPECIFICITY; TRANSCRIPTION INITIATION;

BETA-GLOBINS; BETA-THALASSEMIA; BLOOD PROTEINS; GENE EXPRESSION REGULATION; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MOLECULAR CHAPERONES; MUTATION; PROMOTER REGIONS, GENETIC; TATA-BINDING PROTEIN ASSOCIATED FACTORS; TISSUE DISTRIBUTION; TRANSCRIPTION FACTOR TFIID; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EUKARYOTA;

EID: 63149139035     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808347106     Document Type: Article

References (55)

1. Thomas MC, Chiang CM (2006) The general transcription machinery and general cofactors. Crit Rev Biochem Mol Biol 41:105-178.
2. Muller F, Demeny MA, Tora L (2007) New problems in RNA polymerase II transcription initiation: Matching the diversity of core promoters with a variety of promoter recognition factors. J Biol Chem 282:14685-14689.
3. Holstege FC, et al. (1998) Dissecting the regulatory circuitry of a eukaryotic genome. Cell 95:717-728.
4. Kuras L, Kosa P, Mencia M, Struhl K (2000) TAF-containing and TAF-independent forms of transcriptionally active TBP in vivo. Science 288:1244-1248.
5. Green MR (2000) TBP-associated factors (TAFIIs): Multiple, selective transcriptional mediators in common complexes. Trends Biochem Sci 25:59-63.
6. Smale ST, Kadonaga JT (2003) The RNA polymerase II core promoter. Annu Rev Biochem 72:449-479.
7. Shao H, et al. (2005) Core promoter binding by histone-like TAF complexes. Mol Cell Biol 25:206-219.
8. Burke TW, Kadonaga JT (1997) The downstream core promoter element DPE is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila. Genes Dev 11:3020-3031.
9. Kutach AK, Kadonaga JT (2000) The downstream promoter element DPE appears to be as widely used as the TATA box in Drosophila core promoters. Mol Cell Biol 20:4754-4764.
10. Gershenzon NI, Ioshikhes IP (2005) Synergy of human pol II core promoter elements revealed by statistical sequence analysis. Bioinformatics 21:1295-1300.
11. Kim TH, et al. (2005)Ahigh-resolution map of active promoters in the human genome. Nature 436:876-880.
12. Zhou T, Chiang CM (2001) The intronless and TATA-less human TAF(II)55 gene contains a functional initiator and a downstream promoter element. J Biol Chem 276:25503-25511.
13. Leach KM, et al. (2003) Characterization of the human β-globin downstream promoter region. Nucleic Acids Res 31:1292-1301.
14. Wobbe CR, Struhl K (1990) Yeast and human TATA-binding proteins have nearly identical DNA sequence requirements for transcription in vitro. Mol Cell Biol 10:3859-3867.
15. Lewis BA, Kim TK, Orkin SH (2000) A downstream element in the human β-globin promoter: Evidence of extended sequence-specific transcription factor IID contacts. Proc Natl Acad Sci USA 97:7172-7177.
16. Cai SP, et al. (1992) Two novel β-thalassemia mutations in the 5′ and 3′ noncoding regions of the β-globin gene. Blood 79:1342-1346.
17. Oner R, et al. (1991) The G → A mutation at position +22 3′ to the cap site of the β-globin gene as a possible cause for a β-thalassemia.Hemoglobin 15:67-76.
18. Miller IJ, Bieker JJ (1993) A novel, erythroid cell-specific murine transcription factor that binds to the CACCC elementand is related to the Kruppel family of nuclear proteins. Mol Cell Biol 13:2776-2786.
19. Donze D, Townes TM, Bieker JJ (1995) Role of erythroid Kruppel-like factor in human γ-to β-globin gene switching. J Biol Chem 270:1955-1959.
20. Nuez B, Michalovich D, Bygrave A, Ploemacher R, Grosveld F (1995) Defective hematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature 375:316-318.
21. Perkins AC, Sharpe AH, Orkin SH (1995) Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor Eklf. Nature 375:318-322.
22. Hodge D, et al. (2006) A global role for EKLF in definitive and primitive erythropoiesis. Blood 107:3359-3370.
23. Drissen R, et al. (2005) The erythroid phenotype of EKLF-null mice: Defects in hemoglobin metabolism and membrane stability. Mol Cell Biol 25:5205-5214.
24. Armstrong JA, Bieker JJ, Emerson BM (1998) A Swi/Snf-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro. Cell 95:93-104.
25. Kadam S, et al. (2000) Functional selectivity of recombinant mammalian Swi/Snf subunits. Genes Dev 14:2441-2451.
26. Zhang W, Bieker JJ (1998)Acetylation and modulation of erythroid Kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases. Proc Natl Acad Sci USA 95:9855-9860.
27. Zhang W, Kadam S, Emerson BM, Bieker JJ (2001) Site-specific acetylation by P300 or CREB binding protein regulates erythroid Kruppel-like factor transcriptional activity via its interaction with the Swi-Snf complex. Mol Cell Biol 21:2413-2422.
28. Bottardi S, Ross J, Pierre-Charles N, Blank V, Milot E (2006) Lineage-specific activators affect β-globin locus chromatin in multipotent hematopoietic progenitors. EMBO J 25:3586-3595.
29. Buschmann T, et al. (2001) Stabilization and activation of p53 by the coactivator protein TAFII31. J Biol Chem 276:13852-13857.
30. Mengus G, May M, Carre L, Chambon P, Davidson I (1997) Human TAF(II)135 potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells. Genes Dev 11:1381-1395.
31. Mazzarelli JM, Mengus G, Davidson I, Ricciardi RP (1997) The transactivation domain of adenovirus E1a interacts with the C terminus of human TAF(II)135. J Virol 71:7978-7983.
32. Hamard PJ, et al. (2005) A functional interaction between ATF7 and TAF12 that is modulated byTAF4. Oncogene 24:3472-3483.
33. Wright KJ, Tjian R (2009) Wnt signaling targets Eto coactivation domain of TAF4/TFIID in vivo. Proc Natl Acad Sci USA 106:55-60.
34. Choi Y, Asada S, Uesugi M (2000) Divergent hTAFII31-binding motifs hidden in activation domains. J Biol Chem 275:15912-15916.
35. Chen X, Bieker JJ (1996) Erythroid Kruppel-like factor (EKLF) contains a multifunctional transcriptional activation domain important for inter-and intramolecular interactions. EMBO J 15:5888-5896.
36. Wong C, et al. (1987) Characterization of β-thalassaemia mutations using direct genomic sequencing of amplified single copy DNA. Nature 330:384-386.
37. Pilon AM, et al. (2006) Alterations in expression and chromatin configuration of The a hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice. Mol Cell Biol 26:4368-4377.
38. Bouilloux F, et al. (2008) EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiation. Blood 112:576-584.
39. Frontini M, et al. (2005) TAF9b (formerly TAF9l) is a bona fide TAF that has unique and overlapping roles with TAF9. Mol Cell Biol 25:4638-4649.
40. Sengupta T, Chen K, Milot E, Bieker JJ (2008) Acetylation of Eklf is essential for epigenetic modification and transcriptional activation of the β-globin locus. Mol Cell Biol 28:6160-6170.
41. Li AG, et al. (2007) An acetylation switch in p53 mediates Holo-TFIID recruitment. Mol Cell 28:408-421.
42. Mencia M, Moqtaderi Z, Geisberg JV, Kuras L, Struhl K (2002) Activator-specific recruitment of TFIID and regulation of ribosomal protein genes in yeast. Mol Cell 9:823-833.
43. Shen WC, et al. (2003) Systematic analysis of essential yeast TAFs in genomewide transcription and preinitiation complex assembly. EMBO J 22:3395-3402.
44. Walker AK, Blackwell TK (2003) A broad but restricted requirement for TAF-5 (human TAFII100) for embryonic transcription in Caenorhabditis elegans. J Biol Chem 278:6181-6186.
45. Walker AK, Rothman JH, Shi Y, Blackwell TK (2001) Distinct requirements for C. elegans TAF(II)S in early embryonic transcription. EMBO J 20:5269-5279.
46. Wassarman DA, Aoyagi N, Pile LA, Schlag EM (2000) TAF250 is required for multiple developmental events in Drosophila. Proc Natl Acad Sci USA 97:1154-1159.
47. Zhou J, Zwicker J, Szymanski P, Levine M, Tjian R (1998) TAFII mutations disrupt dorsal activation in the Drosophila embryo. Proc Natl Acad Sci USA 95:13483-13488.
48. Aoyagi N, Wassarman DA (2001) Developmental and transcriptional consequences of mutations in Drosophila TAF(II)60. Mol Cell Biol 21:6808-6819.
49. Wright KJ, Marr MT, Tjian R (2006) TAF4 nucleates a core subcomplex of TFIID and mediates activated transcription from a TATA-less promoter. Proc Natl Acad Sci USA 103:12347-12352.
50. Lee DH, et al. (2005) Functional characterization of core promoter elements: The downstream core element is recognized by TAF1. Mol Cell Biol 25:9674-9686.
51. Burke TW (1996) Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters. Genes Dev 10:711-724.
52. Keys JR, et al. (2007) Genomic organization and regulation of murine α hemoglobin stabilizing protein by erythroid Kruppel-like factor. Br J Haematol 136:150-157.
53. Siatecka M, Xue L, Bieker JJ (2007) Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis. Mol Cell Biol 27:8547-8560.
54. Im H, et al. (2005) Chromatin domain activation via Gata-1 utilization of a small subset of dispersed Gata motifs within a broad chromosomal region. Proc Natl Acad Sci USA 102:17065-17070.
55. Lohmann F, Bieker JJ (2008) Activation of EKLF expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment. Development 135:2071-2087.