Competitive inhibition of uracil DNA glycosylase by a modified nucleotide whose triphosphate is a substrate for DNA polymerase

Journal of the American Chemical Society

Volumn 131, Issue 4, 2009, Pages 1344-1345

  Huang, Haidong ^a   Stivers, James T ^b   Greenberg, Marc M ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-CANCER AGENTS; BASE EXCISION REPAIRS; COMPETITIVE INHIBITION; DEOXYURIDINE; DNA DUPLEXES; DNA MOLECULES; DNA POLYMERASE; DNA REPAIR; E. COLI; IN-CELL; INHIBITORY EFFECT; KLENOW FRAGMENT; MODIFIED NUCLEOTIDES; NANOMOLAR; NUCLEOTIDE ANALOGUES; NUCLEOTIDE TRIPHOSPHATE; POTENTIAL BENEFITS; REPLICATIVE POLYMERASE; THERAPEUTIC AGENTS; TRIPHOSPHATE; URACIL-DNA GLYCOSYLASE;

AMPLIFICATION; DNA; ESCHERICHIA COLI; FUNCTIONAL POLYMERS; GENES; MOLECULES; OLIGONUCLEOTIDES; POLYMERS; SUBSTRATES; SULFUR COMPOUNDS;

NUCLEIC ACIDS;

1 CYANO 2 DEOXYURIDINE; 2 DEOXYNUCLEOTIDE TRIPHOSPHATE; DEOXYRIBONUCLEOTIDE; DNA POLYMERASE; ENZYME INHIBITOR; GLYCOSIDASE INHIBITOR; NUCLEOTIDE; NUCLEOTIDE DERIVATIVE; UNCLASSIFIED DRUG; URACIL DNA GLYCOSIDASE; DNA DIRECTED DNA POLYMERASE; PHOSPHATE;

ARTICLE; COMPETITIVE INHIBITION; DNA REPAIR; DRUG SYNTHESIS; ENZYME INHIBITION; EXCISION REPAIR; MOLECULAR MODEL; THERMODYNAMICS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; METABOLISM; TRANSITION TEMPERATURE;

DNA-DIRECTED DNA POLYMERASE; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEOTIDES; PHOSPHATES; SUBSTRATE SPECIFICITY; THERMODYNAMICS; TRANSITION TEMPERATURE; URACIL-DNA GLYCOSIDASE;

EID: 63149097927     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja807705z     Document Type: Article

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