Synthesis and characterization of oligonucleotides containing 2′-fluorinated thymidine glycol as inhibitors of the endonuclease III reaction

Nucleic Acids Research

Volumn 34, Issue 5, 2006, Pages 1540-1551

  Doi, Yusuke ^a   Katafuchi, Atsushi ^b   Fujiwara, Yoshie ^a   Hitomi, Kenichi ^a,c   Tainer, John A ^c   Ide, Hiroshi ^b   Iwai, Shigenori ^a  

^a OSAKA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5' O (4,4' DIMETHOXYTRITYL) 3' O BENZOYL 2' FLUOROTHYMIDINE; 5' O (4,4' DIMETHOXYTRITYL) 3' O BENZOYL 5,6 DIHYDRO 5,6 DI[(TERT BUTYL)DIMETHYLSILYLOXYL] 2' FLUOROTHYMIDINE; 5' O (4,4' DIMETHOXYTRITYL) 3' O BENZOYL 5,6 DIHYDRO 5,6 DIHDROXY 2' FLUOROTHYMIDINE; 5' O (4,4' DIMETHOXYTRITYL) 5,6 DIHYDRO 5,6 DI[(TERT BUTYL)DIMETHYLSILYLOXYL] 2' FLUOROTHYMIDINE; 5' O (4,4' DIMETHOXYTRITYL) 5,6 DIHYDRO 5,6 DI[(TERT BUTYL)DIMETHYLSILYLOXYL] 2' FLUOROTHYMIDINE 3' [(2 CYANOETHYL) N,N DIISOPROPYL]PHOSPHORAMIDITE; ENDONUCLEASE; ENDONUCLEASE III; OLIGONUCLEOTIDE; THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG; 1 (2 DEOXY 2 FLUORORIBOFURANOSYL) 5,6 DIHYDRO 5,6 DIHYDROXYTHYMINE; 1-(2-DEOXY-2-FLUORORIBOFURANOSYL)-5,6-DIHYDRO-5,6-DIHYDROXYTHYMINE; DEOXYRIBONUCLEASE (PYRIMIDINE DIMER); DRUG DERIVATIVE; ENDONUCLEASE V, PHAGE T4; ENZYME INHIBITOR; ESCHERICHIA COLI PROTEIN; NTH PROTEIN, E COLI; ORGANOPHOSPHORUS COMPOUND; PHOSPHORAMIDOUS ACID; THYMIDINE; VIRUS PROTEIN;

ARTICLE; DRUG DETERMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME MECHANISM; HUMAN; ISOMER; MOLECULAR STABILITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEIC ACID ANALYSIS; NUCLEIC ACID STRUCTURE; OXIDATION; PRIORITY JOURNAL; STEREOCHEMISTRY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; CHEMISTRY; ENZYME SPECIFICITY; ISOMERISM; METABOLISM; SYNTHESIS;

ESCHERICHIA COLI;

DEOXYRIBONUCLEASE (PYRIMIDINE DIMER); ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; ISOMERISM; OLIGONUCLEOTIDES; ORGANOPHOSPHORUS COMPOUNDS; SUBSTRATE SPECIFICITY; THYMIDINE; VIRAL PROTEINS;

EID: 33645531920     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkl061     Document Type: Article

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