Regulation of protein kinases and coregulatory interplay of S-100β and serotonin transporter on serotonin levels in diabetic rat brain

Journal of Neuroscience Research

Volumn 87, Issue 1, 2009, Pages 246-259

  Ramakrishnan, R ^a   Sheeladevi, R ^b   Namasivayam, A ^b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MADRAS   (India)

Author keywords

Diabetes; Protein kinases; Rat brain; S 100 ; Serotonin; SERT

Indexed keywords

8 BROMO CYCLIC AMP; ALLOXAN; CHELERYTHRINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE 2; INSULIN ZINC SUSPENSION; MITOGEN ACTIVATED PROTEIN KINASE P38; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN S100B; SEROTONIN; SEROTONIN TRANSPORTER;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DIABETES MELLITUS; ENZYME ACTIVITY; ENZYME REGULATION; HIPPOCAMPUS; HYPERGLYCEMIA; HYPOTHALAMUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MESENCEPHALON; NONHUMAN; PONS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; SEROTONIN BRAIN LEVEL;

ACETOACETATES; ALLOXAN; ANALYSIS OF VARIANCE; ANIMALS; BLOOD GLUCOSE; BRAIN; CARBONATES; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROGEN-ION CONCENTRATION; MALE; NERVE GROWTH FACTORS; PROTEIN KINASES; RATS; RATS, WISTAR; S100 PROTEINS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TIME FACTORS;

EID: 63049093721     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21833     Document Type: Article

References (72)

1. Adams JP, Sweatt JD. 2002. Molecular psychology roles for the ERK MAP kinase cascade in memory. Annu Rev Pharmacol Toxicol 42:135-163.
2. Akin D, Manier DH, Sanders-Bush E, Shelton RC. 2005. Signal transduction abnormalities in melancholic depression. Int J Neuropsychopharmacol 1:5-16.
3. Andrade R. 1998. Regulation of membrane excitability in the central nervous system by serotonin receptor subtypes. Ann N Y Acad Sci 861:190-203.
4. Ansell GB, Beeson MF. 1968. A rapid and sensitive procedure for the combined assay of noradrenaline, dopamine and serotonin in a single brain sample. Anal Biochem 23:196-206.
5. Azmitia EC. 2001. Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis. Brain Res Bull 56:413-424.
6. Azmitia EC, Rubinstein VJ, Strafici JA, Rios JC, Whitaker-Azmitia PM. 1995. 5-HT1A agonist and dexamethasone reversal of para-chloroamphetamine induced loss of MAP-2 and synaptophysin immunoreactivity in adult rat brain. Brain Res 677:181-192.
7. Baydas G, Nedzvetskii VS, Tuzcu M, Yasar A, Kirichenko, SV. 2003. Increase of glial fibrillary acidic protein and S-100β in hippocampus and cortex of diabetic rats: effects of vitamin. Eur J Pharmacol 462:67-71.
8. Bhattacharya S, Raote I, Bhattacharya A, Miledi R, Panicker MM. 2006. Activation, internalization, and recycling of the serotonin 2A receptor by dopamine. Proc Natl Acad Sci U S A 103:15248-15253.
9. Bianchi R, Garbuglia M, Verzini M, Giambanco I, Ivanenkov VV, Dimlich RVW, Jamieson GA, Donato R. 1996, S100 (α and β)-binding peptide (TRTK-12) blocks S100/GFAP interaction: identification of a putative S100 target epitope within the head domain of GFAP. Biochim Biophys Acta 1313:258-267.
10. Bitar M, Koulu M, Rapoport SI, Linnoila M. 1986. Diabetes induced alterations in brain monoamine metabolism in rats. J Pharmacol Exp Ther 236:432-437.
11. Braun AP, Schulman H. 1995. The multifunctional calcium/ calmodulin-dependent protein kinase: from form function. Annu Rev Physiol 57:417-445.
12. Cerutti SM, Chadi G. 2000. S100 immunoreactivity is increased in reactive astrocytes of the visual pathways following a mechanical lesion of the rat occipital cortex. Cell Biol Int 24:35-49.
13. Chang DJ, Li XC, Lee YS, Kim HK, Kim US, Cho NJ, Lo X, Weiss KR, Kandel ER, Kaang BK. 2000. Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation in aplysia sensory neurons. Proc Natl Acad Sci U S A 97:1829-1834.
14. Chang MS, Ariah LM, Marks A, Azmitia EC. 2005. Chronic gliosis induced by loss of S-100β: knockout mice have enhanced GFAP-immunoreactivity but blunted response to a serotonin challenge. Brain Res 1031:1-9.
15. Chen K. 2004. Organization of MAOA and MAOB promoters and regulation of gene expression. Neurotoxicology 25:31-36.
16. Choi DS, Kellermann O, Richard S, Colas JF, Bolanos-Jimenez F, Tournois C, Launay JM, Maroteaux L. 1998. Mouse 5HT2B receptor-mediated serotonin trophic functions. Ann N Y Acad Sci 861:67-73.
17. Cooper G, Mc Daniel V. 1970. The determination of glucose by the ortho-toluidine method (filtrate and direct procedure). In: Mc Donald RP, editor. Standard methods in clinical chemistry, New York: Academic Press. p 59.
18. Crandall EA, Fernstrom JD. 1980. Acute changes in brain tryptophan and serotonin after carbohydrate or protein ingestion by diabetic rats. Diabetes 29:460-466.
19. Davis RJ. 1993. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268:14553-14556.
20. Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz P.J. 1997. Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors: convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. J Biol Chem 272:19125-19132.
21. 2+ acts through protein kinase C to regulate rabbit ileal NaCl absorption. J Clin Invest 83:1953-1962.
22. Efendic S, Kindmark H, Berggren PO. 1991. Mechanisms involved in the regulation of the insulin secretory process. J Intern Med 229:9-22.
23. Efrain C, Azmitia PhD, Patricia M, Whitaker-Azmitia PhD. 2000. Anatomy. Cell biology and maturation of the serotonergic system: neurotrophic implications for the actions of psychotrophic drugs. Neuropsycho-pharmacology 4:786-795.
24. Eugene MS, Timothy JS. 2003. Phorbol esters and neurotransmitter release: more than just protein kinase C? Br J Pharmacol 138:1191-1201.
25. Fernstrom JD, Wurtman RJ. 1971. Brain serotonin content: increase following ingestion of carbohydrate diet. Science 174:1023-1025.
26. 2 binds the rod domain. Biochim Biophys Acta 1313:268-276.
27. Gardoni F, Kamal A, Bellone C, Biessels GJ, Ramakers GMJ, Cattabeni F, Gispen WH, Luca MD. 2002. Effects of streptozotocin-diabetes on the hippocampal NMDA receptor complex in rats. J Neurochem 80:438-447.
28. Gibbard S, Watkins PJ. 1968. A micro method for the enzymatic determination of D-beta-hydroxybutyrate and acetoacetate. Clin Chim Acta 19:511-521.
29. 3H)dopa in various regions of the brain. J Neurochem 13:655-699.
30. Griffin WS, Sheng JG, Royston MC, Gentleman SM, McKenzie JE, Graham DI, Roberts GW, Mark RE. 1998. Glial-neuronal interactions in Alzheimer's disease: the potential role of a "cytokine cycle" in disease progression. Brain Pathol 8:65-72.
31. Gutkind JS. 1998. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem 273:1839-1842.
32. Hahn CG, Umapathy A, Wang HY, Koneru R, Levinson DF, Friedman E. 2005. Lithium and valproic acid treatments reduce PKC activation and receptor-G protein coupling in platelets of bipolar manic patients. J Psychiatr Res 39:355-363.
33. Heils A, Mossner R, Lesch KP. 1997. The human serotonin transporter gene polymorphism - basic research and clinical implications. J Neural Transm 104:1005-1014.
34. Herlaar E, Brown Z. 1999. p38 MAPK signalling cascades in inflammatory disease. Mol Med Today 5:439-447.
35. Honda I, Kamiya H, Yamo H. 2000. Re-evaluation of phorbol ester-induced potentiation of transmitter release from mossy fiber terminals of the mouse hippocampus. J Physiol 529:763-776.
36. Hori T, Takai Y, Takahashi T. 1999. Presynaptic mechanism for phorbol ester-induced synaptic potentiation. J Neurosci 19:7262-7267.
37. 2+/ calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function. Annu Rev Biochem 71:473-510.
38. Jayanthi LD, Ramamoorthy S. 2005. Regulation of monoamine transporters: influence of psychostimulants and therapeutic antidepressants. AAPS J 7:E728-E738.
39. Kari HP, Davidson PP, Herbert HH, Kochar MH. 1978. Effects of ketamine on the Brain monoamine levels in rats. Res Commun Chem Pathol Pharmacol 20:475-488.
40. Kyosseva SV, Owens SM, Elbein AD, Karson CN. 2000. Differential and region-specific activation of mitogen-activated protein kinases following chronic administration of phencyclidine in rat brain. Neuropsychopharmacology 24:267-277.
41. Lackovic Z, Salkovic M, Kuci K, Relja M. 1990. Effect of long-losting diabetes mellitus on rat and human brain monoamines. J Neurochem 54:143-147.
42. Lowry OH, Osenbrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with Folin phenol reagent. J Biol Chem 193:265-275.
43. Majewski H, Iannazzo L. 1998. Protein kinase C a physiological mediator of enhanced transmitter output. Prog Neurobiol 55:463-475.
44. Martin-Pere J, Thomas G. 1983. Ordered phosphorylation of 40S ribosomal protein S6 after serum stimulation of quiescent 3T3 cell. Proc Natl Acad Sci U S A 80:929-930.
45. Pakaski M, Bjelik A, Hugyecz M, Kasa P, Janka Z, Kalman J. 2005. Imipramine and citalopram facilitate amyloid precursor protein secretion in vitro. Neurochem Int 47:190-195
46. Pineyro G, Blier P. 1999. Autoregulation of serotonin neurons: role in antidepressant drug action. Pharmacol Rev 51:533-591.
47. Prat A, Biernacki K, Wosik K, Antel JP. 2001. Glial cell influence on the blood-brain barrier. Glia 36:145-155.
48. Ramakrishnan R, Namasivayam A. 1995. Norepinephrine and epinephrine levels in the brain of alloxan diabetic rats. Neurosci Lett 186:200-202.
49. Ramakrishnan R, Nazer MY, Suthanthirarajan N, Namasivayam A. 2003. An experimental analysis of the catecholamine's in hyperglycemia and acidosis-induced rat brain. Int J Immunopathol Pharmacol 16:233-239.
50. Ramakrishnan R, Sheeladevi R, Suthanthirarajan N. 2004. PKC-alpha mediated alterations of indoleamine contents in diabetic rat brain. Brain Res Bull 64:189-194.
51. 2+/ calmodulin-dependent protein kinase II in the modulation of indolamines in diabetic and hyperglycemic rats. J Neurosci Res 80:518-528.
52. Ramakrishnan R, Sheeladevi R, Suthanthirarajan N, Namasivayam A. 2005b. An acute hyperglycemia or acidosis-induced changes of indolamines level correlates with PKC-α expression in rat brain. Brain Res Bull 67:46-52.
53. Ramakrishnan R, Kempuraj D, Prabhakaran K, Jayakumar AR, Sheeladevi R, Suthanthirarajan N. 2005c. A short-term diabetes induced changes of catecholamine's and p38-MAPK in discrete areas of rat brain. Life Sci 77:1825-1835.
54. Ramos AJ, Tagliaferro P, Lopez EM, Pecci Saavedra J, Brusco A. 2000. Neuroglial interactions in a model of para-chlorophenylalanine-induced serotonin depletion. Brain Res 883:1-14.
55. Redman RS, Searl TJ, Hirsh JK, Silinsky EM. 1997. Opposing effects of phorbol esters on transmitter release and calcium currents at frog motor nerve endings. J Physiol 501:41-48.
56. Rincón M, Enslen H, Raingeaud J, Recht M, Zapton T, Su MSS, Penix LA, Davis RJ, Flavell RA. 1998. Interferon-γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J 17:2817-2829.
57. Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F. 2005. Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac. FEBS Lett 579:1136-1142.
58. Shapira R, Silberberg SD, Ginsburg S, Rahamimoff R. 1987. Activation of protein kinase C augments evoked transmitter release. Nature 325:58-60.
59. Stenfors C, Ross SB. 2002. Evidence for involvement of protein kinases in the regulation of serotonin synthesis and turnover in the mouse brain in vivo. J Neural Transm 109:1353-1363.
60. Takekoshi K, Ishii K, Nanmoku T, Shibuya S, Kawakami Y, Isobe K, Nakai T. 2001. Leptin stimulates catecholamine synthesis in a PKC-dependent manner in cultured porcine adrenal medullary chromaffin cells. Endocrinology 142:4861-4871.
61. Tan H, Zhong P, Yan Z. 2004. Corticotropin-releasing factor and acute stress prolongs serotonergic regulation of GABA transmission in prefrontal cortical pyramidal neurons. J Neurosci 24:5000-5008.
62. Thomas G. 1992. MAP kinase by any other name smells just as sweet. Cell 68:3-6.
63. Trulson ME, Himmel CD. 1985. Effects of insulin and streptozotocin induced diabetes on brain norepinephrine metabolism in rats. J Neurochem 44:1873-1876.
64. Tsacopoulos M, Magistretti PJ. 1996. Metabolic coupling between glia and neurons. J Neurosci 16:877-885.
65. Vanhoutte P, Nissen JL, Brugg B, Gaspera BD, Besson MJ, Hipskind RA, Caboche J. 2001. Opposing roles of Elk-1 and its brain-specific isoform, short Elk-1, in nerve growth factor-induced PC12 differentiation. J Biol Chem 276:5189-5196.
66. Wang HY,Markowitz P, Levinson D, Undie AS, Friedman E. 1999. Increased membrane-associated protein kinase C activity and translocation in blood platelets from bipolar affective disorder patients. J Psychiatr Res 33:171-179.
67. Whitaker-Azmitia PM. 2001. Serotonin and brain development: role in human developmental diseases. Brain Res Bull 56:479-485.
68. Wu D, Yang CM, Lau YT, Chen JC. 1998. Mechanism of catecholamine-induced proliferation of vascular smooth muscle cells. Circulation 98:94.
69. Wesselmann U, Konkol RJ, Roerig DL, Harder DR. 1988. Early effects of experimental diabetes on central catecholamine concentrations. Brain Res Bull 20:651-654.
70. Youdim MB, Weinstock M. 2001. Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]. Cell Mol Neurobiol 21:555-573.
71. Yu SM, Tsai SY, Guh JH, Ko FN, Teng CM, Ou JT. 1996. Mechanism of catecholamine-induced proliferation of vascular smooth muscle cells. Circulation 94:547-554.
72. Zhang S, Kaplan MH. 2000. The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-γ expression. J Immunol 165:1374-1380.