The effects of roll compaction equipment variables, granulation technique, and HPMC polymer level on a controlled-release matrix model drug formulation

Pharmaceutical Technology

Volumn 23, Issue 3, 1999, Pages 90-106

  Sheskey, Paul J ^a   Hendren, Jeremy ^b  

^a DOW CHEMICAL COMPANY   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; LACTOSE; MAGNESIUM STEARATE; THEOPHYLLINE;

ARTICLE; CONTROLLED RELEASE FORMULATION; DENSITY; DRUG GRANULATION; DRUG RELEASE; DRUG SOLUBILITY; EQUIPMENT; PARTICLE SIZE; TABLET COMPRESSION; TABLET FRIABILITY; TABLET HARDNESS; TABLET MATRIX; TABLET THICKNESS;

EID: 0032975301     PISSN: 01478087     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. D. A. Alderman, "A Review of Cellulose Ethers in Hydrophilic Matrices for Oral Controlled-Release Dosage Forms," Int. J. Pharm. Technol. Prod. Mfr. 5, 1-9 (1984).
2. J.L. Ford et al., "Importance of Drug Type, Tablet Shape, and Added Diluents on Drug Release Kinetics from Hydroxypropyl Methylcellulose Matrix Tablets," Int. J. Pharm. 40, 223-234 (1987).
3. C.D. Melia, "Hydrophilic Sustained Release Systems Based on Polysaccharide Carriers," Critical Reviews in Therapeutic Drug Carrier Systems 8 (4), 395-421 (1991).
4. P. Timmins et al., "Evaluation of the Granulation of a Hydrophilic Matrix Sustained Release Tablet," Drug Dev. Ind. Pharm. 17 (4), 531-550 (1991).
5. T.C. Dahl and A.P. Bormeth, "Naproxen Controlled Release Matrix Tablets: Fluid Bed Granulation Feasibility," Drug Dev. Ind. Pharm. 16 (4), 581-590 (1990).
6. T.D. Reynolds et al., "Polymer Erosion and Drug Release Characterization of Hydroxypropyl Methylcellulose Matrices," J. Pharm. Sci. 87 (9), 1115-1123 (1998).
7. P.J. Sheskey and D.M. Williams, "Comparison of Low-Shear and High-Shear Wet Granulation Techniques and the Influence of Percent Water Addition in the Preparation of a Controlled-Release Matrix Tablet Containing HPMC and a High-Dose, Highly Water-Soluble Drug," Pharm. Technol. 20 (3), 80-92 (1996).
8. P.J. Sheskey et al., "Use of Roller Compaction in the Preparation of Controlled-Release Hydrophilic Matrix Tablets Containing Methylcellulose and Hydroxypropyl Methylcellulose Polymers," Pharm. Technol. 18 (9), 132-150 (1994).
9. M.A. Murray, "Effect of Formulation and Roller Compactor Processing Variables on Granule and Tablet Characteristics," PhD Dissertation, Univ. of Cincinnati (1997).
10. J.P. Remon, "Attempts to Model the Roller Compaction Process and Development of a New Method to Improve Product Quality," 1998 AAPS Annual Meeting Abstracts 1 (1), S-127 (1998).
11. P.J. Sheskey and T.P. Dasbach, "Evaluation of Various Polymers as Dry Binders in the Preparation of an Immediate-Release Tablet Formulation by Roller Compaction," Pharm. Technol. 19 (10), 98-112 (1995).
12. R.W. Miller, "Roller Compaction Technology," in Handbook of Pharmaceutical Granulation Technology, D.M. Parikh, Ed. (Marcel Dekker, Inc., New York, 1997), pp. 99-150.
13. G.E. Peck, "Principles of Tablet Granulation," in Proceedings of Tablet Manufacturing '93 (Medical Manufacturing TechSource, Inc., Ann Arbor, MI, 1993), pp. 240-265.
14. G.E. Peck, "Contemporary Issues for Pharmaceutical Sciences," Pharm. Technol. 18 (8), 43-44 (1994).
15. Y. Funakoshi, T. Asogawa, and E. Satake, "The Use of a Novel Roller Compactor with a Concavo-Convex Roller Pair to Obtain Uniform Compaction Pressure," Drug Dev. Ind. Pharm. 3 (6), 555-573 (1977).
16. E.L. Parrott, "Densification of Powders by Concavo-Convex Roller Compactor," J. Pharm. Sci. 3 (70), 288-291 (1981).
17. "Roller Compactor-Dry Granulation of Powders for Pharmaceuticals, Chemicals, and Foods," technical literature (Vector Corp., Marion, IA, 1982).
18. J.T. Carstensen, Pharmaceutics of Solids and Solid Dosage Forms (John Wiley & Sons, New York, 1977).
19. M.L. Malkowska and K.A. Kahn, "Effect of Recompression on the Properties of Tablets Prepared by Dry Granulation," Drug Dev. Ind. Pharm. 9 (3), 331-347 (1983).