Predicting the tensile strength of compacted multi-component mixtures of pharmaceutical powders

Pharmaceutical Research

Volumn 23, Issue 8, 2006, Pages 1898-1905

  Wu, Chuan Yu ^a,b   Best, Serena M ^a   Bentham, A Craig ^c   Hancock, Bruno C ^d   Bonfield, William ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Compact ability; Multi component blends; Solid fraction; Tablets; Tensile strength

Indexed keywords

EXCIPIENT; HYDROXYPROPYLMETHYLCELLULOSE; LACTOSE; MICROCRYSTALLINE CELLULOSE; STARCH;

ARTICLE; DENSITY; DRUG INDUSTRY; DRUG MIXTURE; MATHEMATICAL MODEL; POWDER; PRIORITY JOURNAL; SOLID; TABLET; TABLET COMPRESSION; TABLET FORMULATION; TENSILE STRENGTH; THEORETICAL MODEL;

ALGORITHMS; CHEMISTRY, PHARMACEUTICAL; DRUG COMBINATIONS; DRUG COMPOUNDING; EXCIPIENTS; MODELS, CHEMICAL; PARTICLE SIZE; POROSITY; POWDERS; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; TABLETS; TENSILE STRENGTH;

EID: 33746911653     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9005-6     Document Type: Article

References (32)

1. C. Y. Wu, O. Ruddy, A. C. Bentham, B. C. Hancock, S. M. Best, and J. A. Elliott. Modelling the mechanical behaviour of pharmaceutical powders during compaction. Powder Technol. 152(1-3):107-117 (2005).
2. C. Y. Wu and A. C. F. Cocks. Flow behaviours of powders during die filling. Powder Metall. 47(2):127-136 (2004).
3. C. Y. Wu, L. Dihoru, and A. C. F. Cocks. The flow of powder into simple and stepped dies. Powder Technol. 134(1-2):24-39 (2003).
4. G. Alderborn and C. Nystrom. Pharmaceutical Powder Compaction Technology, Marcel Dekker Inc, New York, 1996.
5. B. C. Hancock, J. T. Colvin, M. P. Mullarney, and A. V. Zinchuk. The relative densities of pharmaceutical powders, blends, dry granulations, and immediate-release tablets. Pharm. Technol. 27:64-80 (2003).
6. J. T. Fell and J. M. Newton. Determination of tablet strength by the diametrical compression test. J. Pharm. Sci. 59:688-691 (1970).
7. H. Vromans, A. H. De Boer, G. K. Bolhuis, C. F. Lerk, K. D. Kussendrager, and H. Bosch. Studies on tableting properties of lactose. 2. Consolidation and compaction of different types of crystalline lactose. Pharm. Weekbl., Sci. Ed. 7(5):186-193 (1985).
8. H. De Boer, H. Vromans, C. F. Lerk, G. K. Bolhuis, K. D. Kussendrager, and H. Bosch. Studies on tableting properties of lactose. 3. The consolidation behavior of sieve fractions of crystalline alpha-lactose monohydrate. Pharm. Weekbl., Sci. Ed. 8(2):145-150 (1986).
9. M. Eriksson and G. Alderborn. The effect of original particle size and tablet porosity on the increase in tensile strength during storage of sodium chloride tablets in a dry atmosphere. Int. J. Pharm. 113(2):199-207 (1995).
10. H. Olsson and C. Nystrom. Assessing tablet bond types from structural features that affect tablet tensile strength. Pharm. Res. 18(2):203-210 (2001).
11. T. Sebhatu and G. Alderborn. Relationships between the effective interparticulate contact area and the tensile strength of tablets of amorphous and crystalline lactose of varying particle size. Eur. J. Pharm. Sci. 8:235-242 (1999).
12. L. W. Wong and N. Pilpel. Effect of particle shape on the mixing of powders. J. Pharm. Pharmacol. 42:1-6 (1990).
13. D. Poquillon, V. Baco-Carles, Tailhades, and E. Andrieu. Cold compaction of iron powders - relations between powder morphology and mechanical properties. Part II. Bending tests: results and analysis. Powder Technol. 126(1):75-84 (2002).
14. C. K. Tye, C. Sun, and G. E. Amindon. Evaluation of the effects of tabletting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction. J. Pharm. Sci. 94(3):465-472 (2005).
15. C. Y. Wu, S. M. Best, A. C. Bentham, B. C. Hancock, and W. Bonfield. A simple predictive model for the tensile strength of binary tablets. Eur. J. Pharm. Sci. 25:331-336 (2005).
16. J. T. Fell and J. M. Newton. The prediction of tensile strength of tablets. J. Pharm. Pharmacol. 22:247-248 (1970).
17. K. A. Riepma, C. F. Lerk, A. H. De Boer, G. K. Bolhuis, and K. D. Kussendrager. Consolidation and compaction of powder mixtures. 1. Binary-mixtures of same particle-size fractions of different types of crystalline lactose. Int. J. Pharm. 66(1-3):47-52 (1990).
18. K. A. Riepma, J. Veenstra, A. H. De Boer, G. K. Bolhuis, K. Zuurman, C. F. Lerk, and H. Vromans. Consolidation and compaction of powder mixtures. 2. Binary-mixtures of different particle-size fractions of α-lactose monohydrate. Int. J. Pharm. 76(1-2):9-15 (1991).
19. W. E. Jetzer. Compaction characteristics of binary-mixtures. Int. J. Pharm. 31(3):201-207 (1986).
20. H. Leuenberger. The compressibility and compactibility of powder systems. Int. J. Pharm. 12(1):41-55 (1982).
21. D. C.-H. Cheng. The tensile strength of powders. Chem. Eng. Sci. 23:1405-1420 (1968).
22. S. Y. Chan, N. Pilpel, and D. C.-H. Cheng. The tensile strengths of single powders and binary mixtures. Powder Technol. 34:173-189 (1983).
23. M. Kuentz and H. Leuenberger. A new theoretical approach to tablet strength of a binary mixture consisting of a well and a poorly compactable substance. Eur. J. Pharm. Biopharm. 49:151-159 (2000).
24. N. Ramírez, L. M. Melgoza, M. Kuentz, H. Sandoval, and I. Caraballo. Comparison of different mathematical models for the tensile strength-relative density profiles of binary tablets. Eur. J. Pharm. Sci. 22:19-23 (2004).
25. E. Ryshkewitch. Compression strength of porous sintered alumina and zirconia. J. Am. Ceram. Soc. 36:65-68 (1953).
26. W. Duckworth. Discussion of ryshkewitch paper. J. Am. Ceram. Soc. 36:68 (1953).
27. R. Steendam and C. F. Lerk. Poly(DL-lactic acid) as a direct compression excipient in controlled release tablets. Part I. Compaction behaviour and release characteristics of poly(DL-lactic acid) matrix tablets. Int. J. Pharm. 175:33-46 (1998).
28. J. E. Barralet, T. Gaunt, A. J. Wright, I. R. Gibson, and J. C. Knowles. Effect of porosity reduction by compaction on compressive strength and microstructure of calcium phosphate cement. J. Biomed. Materi. Res. 63:1-9 (2002).
29. U. Gbureck, O. Grolms, J. E. Barralet, L. M. Grover, and R. Thull. Mechanical activation and cement formation of β-tricalcium phosphate. Biomaterials 24:4123-4131 (2003).
30. H. S. Shin, S. K. Lee, and B. K. Lee. Aggregate and necking force in Mn-Zn ferrite. Mater. Lett. 57:1467-1470 (2003).
31. H. Vromans, G. K. Bolhuis, C. F. Lerk, and K. D. Kussendrager. Studies of tabletting properties of lactose. 9. The relationship between particle structure and compactibility of crystalline lactose. Int. J. Pharm. 39(3):207-212 (1987).
32. I. H. Moon and J. S. Choi. Dependence of green strength on contact area between powder particles for spherical copper-powder compacts. Powder Metall. 28(1):21-26 (1985).