GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986

Cell Death and Differentiation

Volumn 16, Issue 4, 2009, Pages 624-637

  Gupta, S K ^a   Mishra, R ^a   Kusum, S ^a   Spedding, M ^b   Meiri, K F ^c   Gressens, P ^d,e,f   Mani, S ^a  

^a National Brain Research Center   (India)

^b INSTITUT DE RECHERCHES SERVIER   (France)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HÔPITAL ROBERT DEBRÉ   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f PremUP   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 3,4 CYCLOPENTANO 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; AMPA RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; EXCITATORY AMINO ACID TRANSPORTER; NEUROMODULIN; VESICULAR GLUTAMATE TRANSPORTER 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL SURVIVAL; CONTROLLED STUDY; EXCITOTOXICITY; MOUSE; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NEUROPROTECTION; NEUROTROPISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; BENZOTHIADIAZINES; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; GAP-43 PROTEIN; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MICE; MICE, KNOCKOUT; NEUROPROTECTIVE AGENTS; POLYMERASE CHAIN REACTION; REACTIVE OXYGEN SPECIES; RECEPTORS, AMPA;

MUS; VERTEBRATA;

EID: 62849104549     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2008.188     Document Type: Article

References (41)

1. Arai A, Kessler M, Xiao P, Ambros-Ingerson J, Rogers G, Lynch G. A centrally active drug that modulates AMPA receptor gated currents. Brain Res 1994; 638: 343-346.
2. Staubli U, Perez Y, Xu FB, Rogers G, Ingvar M, Stone-Elander S et al Centrally active modulators of glutamate receptors facilitate the induction of long-term potentiation in vivo. Proc Natl Acad Sci USA 1994; 91: 11158-11162.
3. Suppiramaniam V, Bahr BA, Sinnarajah S, Owens K, Rogers G, Yilma S et al. Member of the Ampakine class of memory enhancers prolongs the single channel open time of reconstituted AMPA receptors. Synapse 2001; 40: 154-158.
4. Ingvar M, Ambros-Ingerson J, Davis M, Granger R, Kessler M, Rogers GA et al. Enhancement by an ampakine of memory encoding in humans. Exp Neurol 1997; 146: 553-559.
5. Hampson RE, Rogers G, Lynch G, Deadwyler SA. Facilitative effects of the ampakine CX516 on short-term memory in rats: Enhancement of delayed-nonmatch-to-sample performance. J Neurosci 1998; 18: 2740-2747.
6. Dicou E, Rangon CM, Guimiot F, Spedding M, Gressens P. Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain. Brain Res 2003; 970: 221-225.
7. Danysz W, Parsons CG. Neuroprotective potential of ionotropic glutamate receptor antagonists. Neurotox Res 2002; 4: 119-126.
8. Danysz W. Positive modulators of AMPA receptors as a potential treatment for schizophrenia. Curr Opin Investig Drugs 2002; 3: 1062-1066.
9. Mackowiak M, O'Neill MJ, Hicks CA, Bleakman D, Skolnick P. An AMPA receptor potentiator modulates hippocampal expression of BDNF: An in vivo study. Neuropharmacology 2002; 43: 1-10.
10. Rex CS, Lauterborn JC, Lin CY, Kramar EA, Rogers GA, Gall CM et al Restoration of long-term potentiation in middle-aged hippocampus after induction of brain-derived neurotrophic factor. J Neurophysiol 2006; 96: 677-685.
11. Staubli U, Rogers G, Lynch G. Facilitation of glutamate receptors enhances memory. Proc Natl Acad Sci USA 1994; 91: 777-781.
12. Marini AM, Rabin SJ, Lipsky RH, Mocchetti I. Activity-dependent release of brain-derived neurotrophic factor underlies the neuroprotective effect of N-methyl-D-aspartate. J Biol Chem 1998; 273: 29394-29399.
13. Courtney MJ, Akerman KE, Coffey ET. Neurotrophins protect cultured cerebellar granule neurons against the early phase of cell death by a two-component mechanism. J Neurosci 1997; 17: 4201-4211.
14. Thomas K, Davies A. Neurotrophins: A ticket to ride for BDNF. Curr Biol 2005; 15: R262-R264.
15. Rose CR, Blum R, Kafitz KW, Kovalchuk Y, Konnerth A. From modulator to mediator: Rapid effects of BDNF on ion channels. Bioessays 2004; 26: 1185-1194.
16. Han BH, Holtzman DM. BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway. J Neurosci 2000; 20: 5775-5781.
17. Hetman M, Kanning K, Cavanaugh JE, Xia Z. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. J Biol Chem 1999; 274: 22569-22580.
18. Nagappan G, Lu B. Activity-dependent modulation of the BDNF receptor TrkB: Mechanisms and implications. Trends Neurosci 2005; 28: 464-471.
19. Bramham CR, Messaoudi E. BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis. Prog Neurobiol 2005; 76: 99-125.
20. Shen Y, Mani S, Donovan SL, Schwob JE, Meiri KF. Growth-associated protein-43 is required for commissural axon guidance in the developing vertebrate nervous system. J Neurosci 2002; 22: 239-247.
21. Frey D, Laux T, Xu L, Schneider C, Caroni P. Shared and unique roles of CAP23 and GAP43 in actin regulation, neurite outgrowth, and anatomical plasticity. J Cell Biol 2000; 149: 1443-1454.
22. Husson I, Rangon CM, Lelievre V, Bemelmans AP, Sachs P, Mallet J et al. BDNF-induced white matter neuroprotection and stage-dependent neuronal survival following a neonatal excitotoxic challenge. Cereb Cortex 2005; 15: 250-261.
23. Segal RA, Pomeroy SL, Stiles CD. Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells. J Neurosci 1995; 15 (7 Part 1): 4970-4981.
24. Hasegawa J, Takekoshi S, Nagata H, Osamura RY, Suzuki T. Sevoflurane stimulates MAP kinase signal transduction through the activation of PKC alpha and betaII in fetal rat cerebral cortex cultured neuron. Acta Histochemica et Cytochemica 2006; 39: 163-172.
25. He Q, Meiri KF. Isolation and characterization of detergent-resistant microdomains responsive to NCAM-mediated signaling from growth cones. Mol Cell Neurosci 2002; 19: 18-31.
26. Pereira DB, Chao MV. The tyrosine kinase Fyn determines the localization of TrkB receptors in lipid rafts. J Neurosci 2007; 27: 4859-4869.
27. Bonfanti L. PSA-NCAM in mammalian structural plasticity and neurogenesis. Prog Neurobiol 2006; 80: 129-164.
28. Gascon E, Vutskits L, Kiss JZ. The Role of PSA-NCAM in Adult Neurogenesis. Neurochem Res 31 May 2008 [e-Pub ahead of print] PMID 18516676.
29. Alonso G, Prieto M, Legrand A, Chauvet N. PSA-NCAM and B-50/GAP-43 are coexpressed by specific neuronal systems of the adult rat mediobasal hypothalamus that exhibit remarkable capacities for morphological plasticity. J Comp Neurol 1997; 384: 181-199.
30. Hou XE, Dahlstrom A. Synaptic vesicle proteins and neuronal plasticity in adrenergic neurons. Neurochem Res 2000; 25: 1275-1300.
31. Nicholls DG, Budd SL. Mitochondria and neuronal survival. Physiol Rev 2000; 80: 315-360.
32. Budd SL, Nicholls DG. Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells. J Neurochem 1996; 67: 2282-2291.
33. Gourlay CW, Ayscough KR. A role for actin in aging and apoptosis. Biochem Soc Trans 2005; 33 (Part 6): 1260-1264.
34. Figiel M, Maucher T, Rozyczka J, Bayatti N, Engele J. Regulation of glial glutamate transporter expression by growth factors. Exp Neurol 2003; 183: 124-135.
35. Rodriguez-Kern A, Gegelashvili M, Schousboe A, Zhang J, Sung L, Gegelashvili G. Beta-amyloid and brain-derived neurotrophic factor, BDNF, up-regulate the expression of glutamate transporter GLT-1/EAAT2 via different signaling pathways utilizing transcription factor NF-kappaB. Neurochem Int 2003; 43: 363-370.
36. Perego C, Vanoni C, Bossi M, Massari S, Basudev H, Longhi R et al. The GLT-1 and GLAST glutamate transporters are expressed on morphologically distinct astrocytes and regulated by neuronal activity in primary hippocampal cocultures. J Neurochem 2000; 75: 1076-1084.
37. Zelenaia O, Schlag BD, Gochenauer GE, Ganel R, Song W, Beesley JS et al. Epidermal growth factor receptor agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on phosphatidylinositol 3-kinase and transcription factor NF-kappaB. Mol Pharmacol 2000; 57: 667-678.
38. Kobayashi NR, Fan DP, Giehl KM, Bedard AM, Wiegand SJ, Tetzlaff W. BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration. J Neurosci 1997; 17: 9583-9595.
39. Lockhart B, Iop F, Closier M, Lestage P. (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3II]noradrenaline release from rat hippocampal and frontal cortex slices. Eur J Pharmacol 2000; 401: 145-153.
40. Gao WO, Heintz N, Hatten ME. Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro. Neuron 1991; 6 705-715.
41. Sharma SK, Carew TJ. Inclusion of phosphatase inhibitors during western blotting enhances signal detection with phospho-specific antibodies. Anal Biochem 2002; 307: 187-189.