(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) A positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices

European Journal of Pharmacology

Volumn 401, Issue 2, 2000, Pages 145-153

  Lockhart, Brian ^a   Iop, Fabrice ^a   Closier, Matthieu ^a   Lestage, Pierre ^a  

^a INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Allosteric modulator; AMPA receptor; Hippocampus; Noradrenaline release; S18986 1

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 2,3 DIHYDRO 3,4 CYCLOPENTANO 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; 6 QUINOXALINECARBOXYLIC ACID PIPERIDIDE; AMPA RECEPTOR; DIZOCILPINE; NOOTROPIC AGENT; NORADRENALIN; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; COGNITION; CONTROLLED STUDY; FRONTAL CORTEX; HIPPOCAMPUS; MALE; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; RAT;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BENZODIAZEPINES; BENZOTHIADIAZINES; CALCIUM; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; EXCITATORY AMINO ACID ANTAGONISTS; FRONTAL LOBE; HIPPOCAMPUS; MALE; NOREPINEPHRINE; PYRROLIDINONES; QUINOXALINES; RATS; RATS, WISTAR; RECEPTORS, AMPA; STEREOISOMERISM; TETRODOTOXIN; TRITIUM;

EID: 0034604753     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00433-7     Document Type: Article

References (41)

1. Arai A., Lynch G. The wave form of synaptic transmission at hippocampal synapses is not determined by AMPA receptor desensitization. Brain Res. 799:1998;230-234.
2. Arai A., Guidotti A., Costa E., Lynch G. Effect of the AMPA receptor modulator IDRA-21 on LTP responses in hippocampal slices. NeuroReport. 7:1996;2211-2215.
3. 3H]-L-glutamate release from rat hippocampal synaptosomes. Br. J. Pharmacol. 113:1994;339-341.
4. Bliss T.V.P., Collingridge G.L. A synaptic model of memory: long term potentiation in the hippocampus. Nature. 361:1993;31-39.
5. Bonhomme N., Greve P., Favale D., Lestage P. Control of acetylcholine release by AMPA receptors in rat prefrontal cortex. Rollema H., Abercrombie E., Sulzer D., Zackheim J. Monitoring Molecules in Neuroscience. 1999;220-221 Pfizer, New York.
6. 3H]noradrenaline from hippocampal slices. Br. J. Pharmacol. 123:1998;473-480.
7. Dakshaben R.P., Croucher M.J. Evidence for a role of presynaptic AMPA receptors in the control of neuronal glutamate release in the rat forebrain. Eur. J. Pharmacol. 332:1997;143-151.
8. Davis M.C., Moskovitz B., Nguyen M.A., Tran B.B., Arai A., Lynch G., Granger R. A profile of behavioral changes produced by facilitation of AMPA-type glutamate receptors. Psychopharmacology. 133:1997;161-167.
9. 3H]Norepinephrine release from rat hippocampal slices. J. Neurochem. 63:1994;231-237.
10. 3H]-Norepinephrine release in rat hippocampal slices. Neuropharmacology. 34:1995;141-147.
11. Desos P., Serkiz B., Morain P., Lepagnol J., Cordi A. Enantioselective synthesis of pyrrolo-benzothiadiazine derivative: S18986-1, a new AMPA receptor positive modulator. Bioorg. Med. Chem. Lett. 6:1996;3003-3008.
12. Giovannini M.G., Rakovska A., Della Corte L., Bianchi L., Pepeu G. Activation of non-NMDA receptors stimulates acetylcholine and GABA release from dorsal hippocampus: a microdialysis study in the rat. Neurosci. Lett. 243:1998;152-156.
13. Granger R., Staubli U., Davis M., Perez Y., Nilsson L., Rogers G.A, Lynch G. A drug that facilitates glutamatergic transmission reduces exploratory activity and improves performance in a learning-dependent task. Synapse. 15:1993;326-329.
14. Granger R., Deadwyler S., Davis M., Moskovitz B., Kessler M., Rogers G., Lynch G. Facilitation of glutamate receptors reverses an age-associated memory impairment in rats. Synapse. 22:1996;332-337.
15. Hampson R.E., Rogers G., Lynch G., Deadwyler S.A. Facilitative effects of the ampakine CX516 on short-term memory in rats: correlations with hippocampal neuronal activity. J. Neurosci. 18:1998;2748-2763.
16. Harley C. Noradrenergic and locus coeruleus modulation of the perforant path-evoked potential in rat dentate gyrus supports a role of the locus coeruleus in attentional and memorial processes. Prog. Brain Res. 88:1991;307-321.
17. Honore T., Davies S.N., Drejer J., Fletcher E.J., Jacobsen P., Lodge D.E., Nielsen F.E. Quinoxalinenediones: potent competitive non-NMDA glutamate receptor antagonists. Science. 241:1988;701-704.
18. Ito I., Tanabe S., Kohda A., Sugiyama H. Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam. J. Physiol. 424:1990;533-543.
19. Izquierdo I., Medina J.H., Bianchin M., Walz R., Zanatta M.S., Da Silva R.C., Silva M.B.E., Ruschel A.C., Paczko N. Memory processing by the limbic system: role of specific neurotransmitter systems. Behav. Brain Res. 58:1993;91-98.
20. Jin S. AMPA and kainate receptors differentially mediate excitatory amino acid-induced dopamine and acetylcholine release from rat striatal slices. Neuropharmacology. 36:1997;1503-1510.
21. Kessler M., Mutneja M.S., Rogers G., Lynch G. Regional preferences of AMPA receptor modulators determined through agonist binding autoradiography. Brain Res. 783:1998;121-126.
22. Larson J., Lieu T., Petchpradub V., LeDuc B., Ngo H., Rogers G.A., Lynch G. Facilitation of olfactory learning by a modulator of AMPA receptors. J. Neurosci. 15:1995;8023-8030.
23. Lebrun C., Roger A., Pilliere E., Albinet K., Krentner M., Lestage P. S18986-1, positive modulator of AMPA-type glutamate receptors a novel cognitive enhancing agent. Soc. Neurosci. Abstr. 24:1998;44.10. (suppl. 1).
24. Lebrun C., Pilliere E., Lestage P. Effect of S18986-1, a novel cognitive enhancer, on memory performances in an object recognition task in rats. Eur. J. Pharmacol. 2000;. (in press).
25. Lepagnol J., Lebrun C., Pilliere E., Thomas J.-Y., Desos P., Cordi A., Lestage P. Neuroexcitatory and cognition enhancing effects of S18986-1, a positive allosteric modulator of glutamate AMPA receptors. Soc. Neurosci. Abstr. 23:1997;717.6. (suppl. 2).
26. 3H]noradrenaline release from rat hippocampal slices. Soc. Neurosci. Abstr. 24:1998;44.9. (suppl. 1).
27. Lynch G., Granger R., Ambros-Ingerson J., Davis C.M., Kessler M., Schehr R. Evidence that a positive modulator of AMPA-type receptors improves delayed recall in aged humans. Exp. Neurol. 145:1997;89-92.
28. 2+ concentration by presynaptic glutamate receptors in hippocampus. Br. J. Pharmacol. 113:1994;1439-1447.
29. Moor E., Auth F., De Boer P., Westerink B.H.C. Septal and hippocampal glutamate receptors modulate the output of acetylcholine in hippocampus: a microdialysis study. J. Neurochem. 67:1996;310-316.
30. Parsons C.G., Wojciech D., Quack G. Glutamate in CNS disorders as a target for drug development: an update. Drug News & Perspect. 11:1998;523-569.
31. Partin K.M., Patneau D.K., Mayer M.L. Cyclothiazide differentially modulates desensitization of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor splice variants. Mol. Pharmacol. 46:1994;129-138.
32. Pittaluga A., Raiteri M. N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release: I. Location on axon terminals and pharmacological characterisation. J. Pharmacol. Exp. Ther. 260:1992;232-237.
33. Pittaluga A., Bonfanti A., Raiteri M. Differential desensitization of ionotropic non-NMDA receptors having distinct neuronal location and function. Naunyn-Schmiedeberg's Arch. Pharmacol. 356:1997;29-38.
34. Pittaluga A., Bonfanti A., Arvigo D., Raiteri M. Aniracetam, 1-BCP and cyclothiazide differentially modulate the function of NMDA and AMPA receptors mediating enhancement of noradrenaline release in rat hippocampal slices. Naunyn-Schmiedeberg's Arch. Pharmacol. 359:1999;272-279.
35. Randle J.C.R., Biton C., Lepagnol J.M. Allosteric potentiation by diazoxide of AMPA receptor currents and synaptic potentials. Eur. J. Pharmacol. 247:1993;257-265.
36. Sekiguchi M., Takeo J., Harada T., Morimoto T., Kudo Y., Yamashita S., Kohsaka S., Wada K. Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures. Br. J. Pharmacol. 123:1998;1294-1303.
37. Staubli U., Rogers G., Lynch G. Facilitation of glutamate receptors enhances memory. Proc. Natl. Acad. Sci. 91:1994;777-781.
38. Thompson D.M., Guidotti A., DiBella M., Costa E. 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA-21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys. Proc. Natl. Acad. Sci. 92:1995;7667-7671.
39. Vizi E.S., Mike A., Tarnawa I. 2,3-benzodiazepines (GYKI52466 and analogs): negative allosteric modulators of AMPA receptors. CNS Drug Rev. 2:1996;91-126.
40. Yamada K.A., Tang C.M. Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents. J. Neurosci. 13:1993;3904-3909.
41. Zivkovic I., Thompson D.M., Bertolino M., Uzunov D., DiBella M., Costa E., Guidotti A. 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA-21): a benzothiadiazine derivative that enhances cognition by attenuating DL-α-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization. J. Pharmacol. Exp. Ther. 272:1995;300-309.