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Volumn 62, Issue 3, 2009, Pages 270-275

Diverse molecular pathways in ovarian cancer and their clinical significance

Author keywords

BRCA; Early detection; Fallopian tube; Molecular pathology; Ovarian cancer; PARP inhibitors; Peritoneal cancer; Two pathway concept

Indexed keywords

ENDOMETRIOSIS; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; HEREDITY; HUMAN; OVARY CANCER; REVIEW; UTERINE TUBE;

EID: 62849100542     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2009.01.001     Document Type: Review
Times cited : (40)

References (58)
  • 1
    • 33745665232 scopus 로고    scopus 로고
    • Stewart B.W., and Kleihues P. (Eds), IARC Press, Lyon, France
    • In: Stewart B.W., and Kleihues P. (Eds). WHO world cancer report (2003), IARC Press, Lyon, France
    • (2003) WHO world cancer report
  • 3
    • 33947184242 scopus 로고    scopus 로고
    • Alternate molecular genetic pathways in ovarian carcinomas of common histological types
    • Willner J., Wurz K., Allison K.H., et al. Alternate molecular genetic pathways in ovarian carcinomas of common histological types. Hum Pathol 38 (2007) 607-613
    • (2007) Hum Pathol , vol.38 , pp. 607-613
    • Willner, J.1    Wurz, K.2    Allison, K.H.3
  • 4
    • 41349101947 scopus 로고    scopus 로고
    • Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesis
    • Kurman R.J., Visvanathan K., Roden R., et al. Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesis. Am J Obstet Gynecol 198 (2008) 351-356
    • (2008) Am J Obstet Gynecol , vol.198 , pp. 351-356
    • Kurman, R.J.1    Visvanathan, K.2    Roden, R.3
  • 5
    • 41349105997 scopus 로고    scopus 로고
    • Histologic subtypes of ovarian carcinoma: an overview
    • Soslow R.A. Histologic subtypes of ovarian carcinoma: an overview. Int J Gynecol Pathol 27 (2008) 161-174
    • (2008) Int J Gynecol Pathol , vol.27 , pp. 161-174
    • Soslow, R.A.1
  • 6
    • 43049099384 scopus 로고    scopus 로고
    • Genomic analysis of epithelial ovarian cancer
    • Farley J., Ozbun L.L., and Birrer M.J. Genomic analysis of epithelial ovarian cancer. Cell Res 18 (2008) 538-548
    • (2008) Cell Res , vol.18 , pp. 538-548
    • Farley, J.1    Ozbun, L.L.2    Birrer, M.J.3
  • 7
    • 41349100528 scopus 로고    scopus 로고
    • Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications
    • Kurman R.J., and Shih Ie M. Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications. Int J Gynecol Pathol 27 (2008) 151-160
    • (2008) Int J Gynecol Pathol , vol.27 , pp. 151-160
    • Kurman, R.J.1    Shih Ie, M.2
  • 8
    • 36448949851 scopus 로고    scopus 로고
    • Etiology and pathogenesis of epithelial ovarian cancer
    • Mok S.C., Kwong J., Welch W.R., et al. Etiology and pathogenesis of epithelial ovarian cancer. Dis Markers 23 (2007) 367-376
    • (2007) Dis Markers , vol.23 , pp. 367-376
    • Mok, S.C.1    Kwong, J.2    Welch, W.R.3
  • 9
    • 39749171410 scopus 로고    scopus 로고
    • Early events in the pathogenesis of epithelial ovarian cancer
    • Landen Jr. C.N., Birrer M.J., and Sood A.K. Early events in the pathogenesis of epithelial ovarian cancer. J Clin Oncol 26 (2008) 995-1005
    • (2008) J Clin Oncol , vol.26 , pp. 995-1005
    • Landen Jr., C.N.1    Birrer, M.J.2    Sood, A.K.3
  • 10
    • 0035421991 scopus 로고    scopus 로고
    • Genetic analysis of early-versus late-stage ovarian tumors
    • Shridhar V., Lee J., Pandita A., et al. Genetic analysis of early-versus late-stage ovarian tumors. Cancer Res 61 (2001) 5895-5904
    • (2001) Cancer Res , vol.61 , pp. 5895-5904
    • Shridhar, V.1    Lee, J.2    Pandita, A.3
  • 11
    • 33745881036 scopus 로고    scopus 로고
    • Salpingo-oophorectomy and the risk of ovarian, fallopian tube, and peritoneal cancers in women with a BRCA1 or BRCA2 Mutation
    • Finch A., Beiner M., Lubinski J., et al. Salpingo-oophorectomy and the risk of ovarian, fallopian tube, and peritoneal cancers in women with a BRCA1 or BRCA2 Mutation. JAMA 296 (2006) 185-192
    • (2006) JAMA , vol.296 , pp. 185-192
    • Finch, A.1    Beiner, M.2    Lubinski, J.3
  • 12
    • 33846187651 scopus 로고    scopus 로고
    • A candidate precursor to serous carcinoma that originates in the distal fallopian tube
    • Lee Y., Miron A., Drapkin R., et al. A candidate precursor to serous carcinoma that originates in the distal fallopian tube. J Pathol 211 (2007) 26-35
    • (2007) J Pathol , vol.211 , pp. 26-35
    • Lee, Y.1    Miron, A.2    Drapkin, R.3
  • 13
    • 33846185401 scopus 로고    scopus 로고
    • The distal fallopian tube: a new model for pelvic serous carcinogenesis
    • Crum C.P., Drapkin R., Miron A., et al. The distal fallopian tube: a new model for pelvic serous carcinogenesis. Curr Opin Obstet Gynecol 19 (2007) 3-9
    • (2007) Curr Opin Obstet Gynecol , vol.19 , pp. 3-9
    • Crum, C.P.1    Drapkin, R.2    Miron, A.3
  • 14
    • 33645225423 scopus 로고    scopus 로고
    • The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome
    • Medeiros F., Muto M.G., Lee Y., et al. The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome. Am J Surg Pathol 30 (2006) 230-236
    • (2006) Am J Surg Pathol , vol.30 , pp. 230-236
    • Medeiros, F.1    Muto, M.G.2    Lee, Y.3
  • 15
    • 55149119938 scopus 로고    scopus 로고
    • The relationship of endometriosis and ovarian malignancy: a review
    • Nezhat F., Datta M.S., Hanson V., et al. The relationship of endometriosis and ovarian malignancy: a review. Fertil Steril 90 (2008) 1559-1570
    • (2008) Fertil Steril , vol.90 , pp. 1559-1570
    • Nezhat, F.1    Datta, M.S.2    Hanson, V.3
  • 16
    • 0034671218 scopus 로고    scopus 로고
    • Loss of heterozygosity on 10q23 3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary
    • Sato N., Tsunoda H., Nishida M., et al. Loss of heterozygosity on 10q23 3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. Cancer Res 60 (2000) 7052-7056
    • (2000) Cancer Res , vol.60 , pp. 7052-7056
    • Sato, N.1    Tsunoda, H.2    Nishida, M.3
  • 18
    • 0026587992 scopus 로고
    • Spontaneous transformation of rat ovarian surface epithelial cells: association with cytogenetic changes and implications of repeated ovulation in the etiology of ovarian cancer
    • Godwin A.K., Testa J.R., Handel L.M., et al. Spontaneous transformation of rat ovarian surface epithelial cells: association with cytogenetic changes and implications of repeated ovulation in the etiology of ovarian cancer. J Natl Cancer Inst 84 (1992) 592-601
    • (1992) J Natl Cancer Inst , vol.84 , pp. 592-601
    • Godwin, A.K.1    Testa, J.R.2    Handel, L.M.3
  • 19
    • 0028261059 scopus 로고
    • Spontaneous transformation of rat ovarian surface epithelial cells results in well to poorly differentiated tumors with a parallel range of cytogenetic complexity
    • Testa J.R., Getts L.A., Salazar H., et al. Spontaneous transformation of rat ovarian surface epithelial cells results in well to poorly differentiated tumors with a parallel range of cytogenetic complexity. Cancer Res 54 (1994) 2778-2784
    • (1994) Cancer Res , vol.54 , pp. 2778-2784
    • Testa, J.R.1    Getts, L.A.2    Salazar, H.3
  • 20
    • 0032477328 scopus 로고    scopus 로고
    • Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone
    • Risch H.A. Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. J Natl Cancer Inst 90 (1998) 1774-1786
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1774-1786
    • Risch, H.A.1
  • 21
    • 0029816209 scopus 로고    scopus 로고
    • Epithelial ovarian cancer risk among women with polycystic ovary syndrome
    • Schildkraut J.M., Schwingl P.J., Bastos E., et al. Epithelial ovarian cancer risk among women with polycystic ovary syndrome. Obstet Gynecol 88 (1996) 554-559
    • (1996) Obstet Gynecol , vol.88 , pp. 554-559
    • Schildkraut, J.M.1    Schwingl, P.J.2    Bastos, E.3
  • 22
    • 0029930874 scopus 로고    scopus 로고
    • Changes in androgens during treatment with four low-dose contraceptives
    • Coenen C.M., Thomas C.M., Borm G.F., et al. Changes in androgens during treatment with four low-dose contraceptives. Contraception 53 (1996) 171-176
    • (1996) Contraception , vol.53 , pp. 171-176
    • Coenen, C.M.1    Thomas, C.M.2    Borm, G.F.3
  • 23
    • 1442327535 scopus 로고    scopus 로고
    • Androgens and ovarian cancers
    • Wang P.H., and Chang C. Androgens and ovarian cancers. Eur J Gynaecol Oncol 25 (2004) 157-163
    • (2004) Eur J Gynaecol Oncol , vol.25 , pp. 157-163
    • Wang, P.H.1    Chang, C.2
  • 24
    • 33645801003 scopus 로고    scopus 로고
    • Endometriosis and the risk of cancer with special emphasis on ovarian cancer
    • Melin A., Sparen P., Persson I., et al. Endometriosis and the risk of cancer with special emphasis on ovarian cancer. Hum Reprod 21 (2006) 1237-1242
    • (2006) Hum Reprod , vol.21 , pp. 1237-1242
    • Melin, A.1    Sparen, P.2    Persson, I.3
  • 26
    • 0033199807 scopus 로고    scopus 로고
    • Possible role of ovarian epithelial inflammation in ovarian cancer
    • Ness R.B., and Cottreau C. Possible role of ovarian epithelial inflammation in ovarian cancer. J Natl Cancer Inst 91 (1999) 1459-1467
    • (1999) J Natl Cancer Inst , vol.91 , pp. 1459-1467
    • Ness, R.B.1    Cottreau, C.2
  • 27
    • 3142717392 scopus 로고    scopus 로고
    • NF-kappaB, macrophage migration inhibitory factor and cyclooxygenase-inhibitions as likely mechanisms behind the acetaminophen- and NSAID-prevention of the ovarian cancer
    • Altinoz M.A., and Korkmaz R. NF-kappaB, macrophage migration inhibitory factor and cyclooxygenase-inhibitions as likely mechanisms behind the acetaminophen- and NSAID-prevention of the ovarian cancer. Neoplasma 51 (2004) 239-247
    • (2004) Neoplasma , vol.51 , pp. 239-247
    • Altinoz, M.A.1    Korkmaz, R.2
  • 28
    • 0032893042 scopus 로고    scopus 로고
    • The role of cytokines in both the normal and malignant ovary
    • Nash M.A., Ferrandina G., Gordinier M., et al. The role of cytokines in both the normal and malignant ovary. Endocr Relat Cancer 6 (1999) 93-107
    • (1999) Endocr Relat Cancer , vol.6 , pp. 93-107
    • Nash, M.A.1    Ferrandina, G.2    Gordinier, M.3
  • 29
    • 33745102031 scopus 로고    scopus 로고
    • Molecular pathology of epithelial ovarian cancer
    • Christie M., and Oehler M.K. Molecular pathology of epithelial ovarian cancer. J Br Menopause Soc (2006) 12
    • (2006) J Br Menopause Soc , pp. 12
    • Christie, M.1    Oehler, M.K.2
  • 30
    • 0032941343 scopus 로고    scopus 로고
    • Cancer risk in mutation carriers of DNA-mismatch-repair genes
    • Aarnio M., Sankila R., Pukkala E., et al. Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer 81 (1999) 214-218
    • (1999) Int J Cancer , vol.81 , pp. 214-218
    • Aarnio, M.1    Sankila, R.2    Pukkala, E.3
  • 31
    • 0034897120 scopus 로고    scopus 로고
    • The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer
    • Watson P., Butzow R., Lynch H.T., et al. The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer. Gynecol Oncol 82 (2001) 223-228
    • (2001) Gynecol Oncol , vol.82 , pp. 223-228
    • Watson, P.1    Butzow, R.2    Lynch, H.T.3
  • 32
    • 30444435538 scopus 로고    scopus 로고
    • Glutathione S-transferase polymorphisms and ovarian cancer treatment and survival
    • Beeghly A., Katsaros D., Chen H., et al. Glutathione S-transferase polymorphisms and ovarian cancer treatment and survival. Gynecol Oncol 100 (2006) 330-337
    • (2006) Gynecol Oncol , vol.100 , pp. 330-337
    • Beeghly, A.1    Katsaros, D.2    Chen, H.3
  • 33
    • 38849190562 scopus 로고    scopus 로고
    • Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set
    • Beesley J., Jordan S.J., Spurdle A.B., et al. Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set. Cancer Epidemiol Biomarkers Prev 16 (2007) 2557-2565
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , pp. 2557-2565
    • Beesley, J.1    Jordan, S.J.2    Spurdle, A.B.3
  • 34
    • 38549127886 scopus 로고    scopus 로고
    • Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis
    • Pearce C.L., Wu A.H., Gayther S.A., et al. Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis. Br J Cancer 98 (2008) 282-288
    • (2008) Br J Cancer , vol.98 , pp. 282-288
    • Pearce, C.L.1    Wu, A.H.2    Gayther, S.A.3
  • 35
    • 0042624835 scopus 로고    scopus 로고
    • Role of KRAS and BRAF gene mutations in mucinous ovarian carcinoma
    • Gemignani M.L., Schlaerth A.C., Bogomolniy F., et al. Role of KRAS and BRAF gene mutations in mucinous ovarian carcinoma. Gynecol Oncol 90 (2003) 378-381
    • (2003) Gynecol Oncol , vol.90 , pp. 378-381
    • Gemignani, M.L.1    Schlaerth, A.C.2    Bogomolniy, F.3
  • 36
    • 0037454224 scopus 로고    scopus 로고
    • Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma
    • Singer G., Oldt III R., Cohen Y., et al. Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. J Natl Cancer Inst 95 (2003) 484-486
    • (2003) J Natl Cancer Inst , vol.95 , pp. 484-486
    • Singer, G.1    Oldt III, R.2    Cohen, Y.3
  • 37
    • 0032054206 scopus 로고    scopus 로고
    • Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas
    • Palacios J., and Gamallo C. Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas. Cancer Res 58 (1998) 1344-1347
    • (1998) Cancer Res , vol.58 , pp. 1344-1347
    • Palacios, J.1    Gamallo, C.2
  • 39
    • 7444250290 scopus 로고    scopus 로고
    • Mutation of the PIK3CA gene in ovarian and breast cancer
    • Campbell I.G., Russell S.E., Choong D.Y., et al. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 64 (2004) 7678-7681
    • (2004) Cancer Res , vol.64 , pp. 7678-7681
    • Campbell, I.G.1    Russell, S.E.2    Choong, D.Y.3
  • 40
    • 0032523808 scopus 로고    scopus 로고
    • Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors
    • Obata K., Morland S.J., Watson R.H., et al. Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors. Cancer Res 58 (1998) 2095-2097
    • (1998) Cancer Res , vol.58 , pp. 2095-2097
    • Obata, K.1    Morland, S.J.2    Watson, R.H.3
  • 41
    • 50249111103 scopus 로고    scopus 로고
    • A review of the clinical relevance of mismatch-repair deficiency in ovarian cancer
    • Pal T., Permuth-Wey J., and Sellers T.A. A review of the clinical relevance of mismatch-repair deficiency in ovarian cancer. Cancer 113 (2008) 733-742
    • (2008) Cancer , vol.113 , pp. 733-742
    • Pal, T.1    Permuth-Wey, J.2    Sellers, T.A.3
  • 42
    • 0035575740 scopus 로고    scopus 로고
    • Microsatellite instability, MLH-1 promoter hypermethylation, and frameshift mutations at coding mononucleotide repeat microsatellites in ovarian tumors
    • Gras E., Catasus L., Arguelles R., et al. Microsatellite instability, MLH-1 promoter hypermethylation, and frameshift mutations at coding mononucleotide repeat microsatellites in ovarian tumors. Cancer 92 (2001) 2829-2836
    • (2001) Cancer , vol.92 , pp. 2829-2836
    • Gras, E.1    Catasus, L.2    Arguelles, R.3
  • 43
    • 0033541548 scopus 로고    scopus 로고
    • Screening for ovarian cancer: a pilot randomised controlled trial
    • Jacobs I.J., Skates S.J., MacDonald N., et al. Screening for ovarian cancer: a pilot randomised controlled trial. Lancet 353 (1999) 1207-1210
    • (1999) Lancet , vol.353 , pp. 1207-1210
    • Jacobs, I.J.1    Skates, S.J.2    MacDonald, N.3
  • 44
    • 41649110649 scopus 로고    scopus 로고
    • Imaging in the era of molecular oncology
    • Weissleder R., and Pittet M.J. Imaging in the era of molecular oncology. Nature 452 (2008) 580-589
    • (2008) Nature , vol.452 , pp. 580-589
    • Weissleder, R.1    Pittet, M.J.2
  • 45
    • 33744730025 scopus 로고    scopus 로고
    • Personalized medicine and development of targeted therapies: The upcoming challenge for diagnostic molecular pathology. A review
    • Dietel M., and Sers C. Personalized medicine and development of targeted therapies: The upcoming challenge for diagnostic molecular pathology. A review. Virchows Arch 448 (2006) 744-755
    • (2006) Virchows Arch , vol.448 , pp. 744-755
    • Dietel, M.1    Sers, C.2
  • 46
    • 52449084470 scopus 로고    scopus 로고
    • Molecular profiling of carcinoma of unknown primary and correlation with clinical evaluation
    • Varadhachary G.R., Talantov D., Raber M.N., et al. Molecular profiling of carcinoma of unknown primary and correlation with clinical evaluation. J Clin Oncol 26 (2008) 4442-4448
    • (2008) J Clin Oncol , vol.26 , pp. 4442-4448
    • Varadhachary, G.R.1    Talantov, D.2    Raber, M.N.3
  • 47
    • 62849110875 scopus 로고    scopus 로고
    • Accessed 15/12/08
    • http://www.cancer.gov/clinicaltrials/GOG-0239. (Accessed 15/12/08).
  • 48
    • 57449092484 scopus 로고    scopus 로고
    • KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer
    • Nakayama N., Nakayama K., Yeasmin S., et al. KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer. Br J Cancer 99 (2008) 2020-2028
    • (2008) Br J Cancer , vol.99 , pp. 2020-2028
    • Nakayama, N.1    Nakayama, K.2    Yeasmin, S.3
  • 49
    • 56249133327 scopus 로고    scopus 로고
    • Inhibition of cell growth and VEGF expression in ovarian cancer cells by flavonoids
    • Luo H., Jiang B.H., King S.M., et al. Inhibition of cell growth and VEGF expression in ovarian cancer cells by flavonoids. Nutr Cancer 60 (2008) 800-809
    • (2008) Nutr Cancer , vol.60 , pp. 800-809
    • Luo, H.1    Jiang, B.H.2    King, S.M.3
  • 50
    • 62849099968 scopus 로고    scopus 로고
    • Accessed 15/12/08
    • http://www.cancer.gov/clinicaltrials/GOG-0170I. (Accessed 15/12/08).
  • 51
    • 48149110374 scopus 로고    scopus 로고
    • The use of monoclonal antibodies for the treatment of epithelial ovarian cancer (review)
    • Oei A.L., Sweep F.C., Thomas C.M., et al. The use of monoclonal antibodies for the treatment of epithelial ovarian cancer (review). Int J Oncol 32 (2008) 1145-1157
    • (2008) Int J Oncol , vol.32 , pp. 1145-1157
    • Oei, A.L.1    Sweep, F.C.2    Thomas, C.M.3
  • 52
    • 53149147473 scopus 로고    scopus 로고
    • The potential of PARP inhibitors in genetic breast and ovarian cancers
    • Drew Y., and Calvert H. The potential of PARP inhibitors in genetic breast and ovarian cancers. Ann N Y Acad Sci 1138 (2008) 136-145
    • (2008) Ann N Y Acad Sci , vol.1138 , pp. 136-145
    • Drew, Y.1    Calvert, H.2
  • 53
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • Bryant H.E., Schultz N., Thomas H.D., et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434 (2005) 913-917
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3
  • 54
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H., McCabe N., Lord C.J., et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434 (2005) 917-921
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3
  • 55
    • 62849102310 scopus 로고    scopus 로고
    • P. C. Fong, D. S. Boss, C. P. Carden, et al. AZD2281 (KU-0059436), a PARP (poly ADP-ribose polymerase) inhibitor with single agent anticancer activity in patients with BRCA deficient ovarian cancer: Results from a phase I study. J Clin Oncol, 2008 ASCO Annual Meeting Proceedings (Post-Meeting Edition). 26, No 15S (May 20 Supplement), 2008: 5510.
    • P. C. Fong, D. S. Boss, C. P. Carden, et al. AZD2281 (KU-0059436), a PARP (poly ADP-ribose polymerase) inhibitor with single agent anticancer activity in patients with BRCA deficient ovarian cancer: Results from a phase I study. J Clin Oncol, 2008 ASCO Annual Meeting Proceedings (Post-Meeting Edition). Vol 26, No 15S (May 20 Supplement), 2008: 5510.
  • 56
    • 62849106997 scopus 로고    scopus 로고
    • Accessed 15/12/08
    • http://clinicaltrials.gov/ct2/show/NCT00516373. (Accessed 15/12/08).
  • 57
    • 62849083414 scopus 로고    scopus 로고
    • Accessed 15/12/08
    • http://clinicaltrials.gov/ct2/show/NCT00753545. (Accessed 15/12/08).
  • 58
    • 62849116315 scopus 로고    scopus 로고
    • Accessed 15/12/08
    • http://www.cancer.gov/clinicaltrials/CRUK-PH2/052. (Accessed 15/12/08).


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