How to measure hepatic insulin resistance?

Diabetes and Metabolism

Volumn 34, Issue 6 PART 2, 2008, Pages 664-673

  Choukem, S P ^a,b   Gautier, J F ^a,b  

^a INSERM   (France)

^b CENTRE DE RECHERCHE DES CORDELIERS   (France)

Author keywords

Hepatic glucose production; Hepatic insulin resistance; Isotope; Review; Tracer

Indexed keywords

CARBON; DEUTERIUM; FATTY ACID; GLUCOSE; INSULIN;

ADULT; BIOLOGICAL MODEL; CHILD; ENERGY METABOLISM; FEMALE; HUMAN; INSULIN RESISTANCE; ISOTOPE DILUTION ASSAY; ISOTOPE LABELING; LIVER; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; REVIEW;

ADULT; CARBON RADIOISOTOPES; CHILD; DEUTERIUM; ENERGY METABOLISM; FATTY ACIDS, NONESTERIFIED; FEMALE; GLUCOSE; HUMANS; INSULIN; INSULIN RESISTANCE; ISOTOPE LABELING; LIVER; MODELS, BIOLOGICAL; PREGNANCY; RADIOISOTOPE DILUTION TECHNIQUE;

EID: 62749191260     PISSN: 12623636     EISSN: 18781780     Source Type: Journal    
DOI: 10.1016/S1262-3636(08)74602-0     Document Type: Article

References (61)

1. American Diabetes Association. Standards of medical care in diabetes- 2007. Diabetes Care 2007;30:S4-S41.
2. Kasuga M. Insulin resistance and pancreatic beta cell failure. J Clin Invest 2006;116:1756-60.
3. Choukem SP, Sobngwi E, Fetita LS, Boudou P, De Kerviler E, Boirie Y, et al. Multi-tissue insulin resistance despite near-normoglycemic remission in Africans with ketosis-prone diabetes. Diabetes Care 2008;DOI:10.2337/dc08-0914.
4. Groop LC, Bonadonna RC, DelPrato S, Ratheiser K, Zyck K, Ferrannini E, et al. Glucose and free fatty acid metabolism in non-insulindependent diabetes mellitus. Evidence for multiple sites of insulin resistance. J Clin Invest 1989;84:205-13.
5. Mitrakou A, Kelley D, Veneman T, Jenssen T, Pangburn T, Reilly J, et al. Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM. Diabetes 1990;39:1381-90.
6. Abdul-Ghani MA, Jenkinson CP, Richardson DK, Tripathy D, DeFronzo RA. Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study. Diabetes 2006;55:1430-5.
7. Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 2004;114:147-52.
8. Guyton AC, Hall JE. Textbook of medical physiology. 9th Ed. Philadelphia: W.B. Saunders Company;1996.
9. Shimomura I, Bashmakov Y, Horton JD. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 1999;274:30028-32.
10. Frayn KN. Metabolic regulation: A human perspective. London: Portland Press Ltd;1999.
11. Andreelli F, Girard J. Régulation de l'homéostasie glucidique. In: Grimaldi A, editor. Traité de diabétologie. Paris: Flammarion Médecine-Sciences;2005. p. 22-40.
12. Petersen KF, Laurent D, Rothman DL, Cline GW, Shulman GI. Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. J Clin Invest 1998;101:1203-9.
13. Roden M, Petersen KF, Shulman GI. Nuclear magnetic resonance studies of hepatic glucose metabolism in humans. Recent Prog Horm Res 2001;56:219-37.
14. Postic C, Dentin R, Denechaud PD, Girard J. ChREBP, a transcriptional regulator of glucose and lipid metabolism. Annu Rev Nutr 2007;27:179-92.
15. Foufelle F, Ferré P. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose:a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J 2002;366:377-91.
16. Diraison F, Yankah V, Letexier D, Dusserre E, Jones P, Beylot M. Differences in the regulation of adipose tissue and liver lipogenesis by carbohydrates in humans. J Lipid Res 2003;44:846-53.
17. Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005;115:1343-51.
18. Rothman DL, Magnusson I, Katz LD, Shulman RG, Shulman GI. Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR. Science 1991;254:573-6.
19. Cherrington AD, Edgerton D, Sindelar DK. The direct and indirect effects of insulin on hepatic glucose production in vivo. Diabetologia 1998;41:987-96.
20. Girard J. Insulin's effect on the liver: "direct or indirect?" continues to be the question. J Clin Invest 2006;116:302-4.
21. Edgerton DS, Lautz M, Scott M, Everett CA, Stettler KM, Neal DW, et al. Insulin's direct effects on the liver dominate the control of hepatic glucose production. J Clin Invest 2006;116:521-7.
22. Chakravarty K, Leahy P, Becard D, Hakimi P, Foretz M, Ferré P, et al. Sterol regulatory element-binding protein-1c mimics the negative effect of insulin on phosphoenolpyruvate carboxykinase (GTP) gene transcription. J Biol Chem 2001;276:34816-23.
23. Wallace TM, Matthews DR. The assessment of insulin resistance in man. Diabet Med 2002;19:527-34.
24. Radziuk J. Insulin sensitivity and its measurement: structural commonalities among the methods. J Clin Endocrinol Metab 2000;85: 4426-33.
25. Monzillo LU, Hamdy O. Evaluation of insulin sensitivity in clinical practice and in research settings. Nutr Rev 2003;61:397-412.
26. Rabasa-Lhoret R, Laville M. How to measure insulin sensitivity in clinical practice? Diabetes Metab 2001;27:201-8.
27. Cherrington AD. Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo. Diabetes 1999;48:1198-214.
28. e symposium international de diabétologie. Genève: Excerpta Medica S.A.;1986. p. 132-47.
29. Caumo A, Cobelli C. Hepatic glucose production during the labeled IVGTT: estimation by deconvolution with a new minimal model. Am J Physiol 1993;264:E829-41.
30. Overkamp D, Gautier JF, Renn W, Pickert A, Scheen AJ, Schmulling RM, et al. Glucose turnover in humans in the basal state and after intravenous glucose:a comparison of two models. Am J Physiol 1997;273:E284-96.
31. Coggan AR. Use of stable isotopes to study carbohydrate and fat metabolism at the whole-body level. Proc Nutr Soc 1999;58:953-61.
32. Basu R, Di Camillo B, Toffolo G, Basu A, Shah P, Vella A, et al. Use of a novel triple-tracer approach to assess postprandial glucose metabolism. Am J Physiol Endocrinol Metab 2003;284:E55-69.
33. Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006;355:2297-307.
34. Robertson JS. Theory and use of tracers in determining transfer rates in biological systems. Physiol Rev 1957;37:133-54.
35. Baker N, Shreeve WW, Shipley RA, Incefy GE, Miller M. C14 studies in carbohydrate metabolism. I. The oxidation of glucose in normal human subjects. J Biol Chem 1954;211:575-92.
36. Patterson KY, Veillon C. Stable isotopes of minerals as metabolic tracers in human nutrition research. Exp Biol Med (Maywood) 2001;226:271-82.
37. Solomon AK. Equations for tracer experiments. J Clin Invest 1949;28:1297-1307.
38. Steele R. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 1959;82:420-30.
39. Steele R, Wall JS, De Bodo RC, Altszuler N. Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol 1956;187:15-24.
40. Hovorka R, Eckland DJ, Halliday D, Lettis S, Robinson CE, Bannister P, et al. Constant infusion and bolus injection of stable-label tracer give reproducible and comparable fasting HGO. Am J Physiol 1997;273:E192-201.
41. Radziuk J, Norwich KH, Vranic M. Experimental validation of measurements of glucose turnover in nonsteady state. Am J Physiol 1978;234:E84-93.
42. Mari A. Estimation of the rate of appearance in the non-steady state with a two-compartment model. Am J Physiol 1992;263:E400-15.
43. 2H-labelled glucose compared for minimal model estimates of glucose metabolism in man. Clin Sci (Lond) 2005;109:513-21.
44. Abdul-Ghani M, DeFronzo RA. Fasting hyperglycemia impairs glucose- but not insulin-mediated suppression of glucagon secretion. J Clin Endocrinol Metab 2007;92:1778-84.
45. Adrogue HJ. Glucose homeostasis and the kidney. Kidney Int 1992;42:1266-82.
46. Cersosimo E, Judd RL, Miles JM. Insulin regulation of renal glucose metabolism in conscious dogs. J Clin Invest 1994;93:2584-9.
47. Gerich JE, Meyer C, Woerle HJ, Stumvoll M. Renal gluconeogenesis: its importance in human glucose homeostasis. Diabetes Care 2001;24:382-91.
48. Diraison F, Moulin P, Beylot M. Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease. Diabetes Metab 2003;29:478-85.
49. Magnusson I, Rothman DL, Gerard DP, Katz LD, Shulman GI. Contribution of hepatic glycogenolysis to glucose production in humans in response to a physiological increase in plasma glucagon concentration. Diabetes 1995;44:185-9.
50. Abdul-Ghani MA, Matsuda M, Balas B, DeFronzo RA. Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test. Diabetes Care 2007;30:89-94.
51. Gastaldelli A, Cusi K, Pettiti M, Hardies J, Miyazaki Y, Berria R, et al. Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. Gastroenterology 2007;133:496-506.
52. Korenblat KM, Fabbrini E, Mohammed BS, Klein S. Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology 2008;134: 1369-75.
53. Yki-Jarvinen H, Kauppinen-Makelin R, Tiikkainen M, Vahatalo M, Virtamo H, Nikkila K, et al. Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study. Diabetologia 2006;49:442-51.
54. Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, et al. Nonalcoholic fatty liver disease:a feature of the metabolic syndrome. Diabetes 2001;50:1844-50.
55. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002;346: 1221-31.
56. Deivanayagam S, Mohammed BS, Vitola BE, Naguib GH, Keshen TH, Kirk EP, et al. Nonalcoholic fatty liver disease is associated with hepatic and skeletal muscle insulin resistance in overweight adolescents. Am J Clin Nutr 2008;88:257-62.
57. Seppala-Lindroos A, Vehkavaara S, Hakkinen AM, Goto T, Westerbacka J, Sovijarvi A, et al. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 2002;87:3023-8.
58. 13C nuclear magnetic resonance study. J Clin Invest 1992;90:1323-7.
59. Hundal RS, Krssak M, Dufour S, Laurent D, Lebon V, Chandramouli V, et al. Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes 2000;49:2063-9.
60. Krssak M, Brehm A, Bernroider E, Anderwald C, Nowotny P, Dalla Man C, et al. Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes. Diabetes 2004;53:3048-56.
61. Petersen KF, Krssak M, Navarro V, Chandramouli V, Hundal R, Schumann WC, et al. Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis. Am J Physiol 1999;276:E529-35.