Insulin's effect on the liver: "Direct or indirect?" Continues to be the question

Journal of Clinical Investigation

Volumn 116, Issue 2, 2006, Pages 302-304

  Girard, Jean ^a  

^a INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCAGON; INSULIN; INSULIN RECEPTOR; POTASSIUM CHANNEL;

CENTRAL NERVOUS SYSTEM; DIET RESTRICTION; DOG; GLUCAGON BLOOD LEVEL; GLUCONEOGENESIS; GLYCOGENOLYSIS; INSULIN BLOOD LEVEL; LIVER; NONHUMAN; PANCREAS ISLET ALPHA CELL; PHENOTYPE; PRIORITY JOURNAL; REVIEW; RODENT; VAGOTOMY;

EID: 32444447035     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI27743     Document Type: Review

References (25)

1. Williamson, J., Wright, P., Malaisse, W., and Ashmore, J. 1966. Control of gluconeogenesis by acetyl CoA in rats treated with glucagon and anti-insulin serum. Biochem. Biophys. Res. Commun. 22:765-770.
2. Ader, M., and Bergman, R. 1990. Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am. J. Physiol. 258:E1020-E1032.
3. Giacca, A., et al. 1992. Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J. Clin. Invest. 90:1769-1777.
4. Lewis, G.F., Zinman, B., Groenewoud, Y., Vranic, M., and Giacca, A. 1996. Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans. Diabetes. 45:454-462.
5. Cherrington, A.D. 2005. The role of hepatic insulin receptors in the regulation of glucose production. J. Clin. Invest. 115:1136-1139. doi:10.1172/JCI200525152.
6. Ishihara, H., Maechler, P., Gjinovci, A., Herrera, P.L., and Wollheim, C.B. 2003. Islet β-cell secretion determines glucagon release from neighbouring alpha-cells. Nat. Cell Biol. 5:330-335.
7. Diao, J., Asghar, Z., Chan, C.B., and Wheeler, M.B. 2005. Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells. J. Biol. Chem. 280:33487-33496.
8. Sindelar, D.K., et al. 1997. The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog. Diabetes. 46:187-196.
9. Sindelar, D.K., Balcom, J.H., Chu, C.A., Neal, D.W., and Cherrington, A.D. 1996. A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes. 45:1594-1604.
10. Obici, S., Feng, Z., Karkanias, G., Baskin, D.G., and Rossetti, L. 2002. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat. Neurosci. 5:566-572.
11. Buettner, C., et al. 2005. Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice. J. Clin. Invest. 115:1306-1313. doi:10.1172/JCI200523109.
12. Cherrington, A. 1999. Control of glucose uptake and release by the liver in vivo. Diabetes. 48:1198-1214.
13. Edgerton, D.S., et al. 2006. Insulin's direct effects on the liver dominate the control of hepatic glucose production. J. Clin. Invest. 116:521-527. doi:10.1172/JCI27073.
14. Fisher, S.J., and Kahn, C.R. 2003. Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production. J. Clin. Invest. 111:463-468. doi:10.1172/JCI200316426.
15. Okamoto, H., Obici, S., Accili, D., and Rossetti, L. 2005. Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action. J. Clin. Invest. 115:1314-1322. doi:10.1172/JCI200523096.
16. Obici, S., Zhang, B.B., Karkanias, G., and Rossetti, L. 2002. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat. Med. 8:1376-1382.
17. Burgess, S.C., et al. 2005. Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting. Am. J. Physiol. 289:E53-E61.
18. Chiasson, J.L., Liljenquist, J.E., Finger, F.E., and Lacy, W.W. 1976. Differential sensitivity of glycogenolysis and gluconeogenesis to insulin infusion in dogs. Diabetes. 25:283-291.
19. Shimazu, T. 1987. Neuronal regulation of hepatic glucose metabolism in mammals. Diabetes Metab. Rev. 3:185-206.
20. Jungermann, K., et al. 1987. Regulation of liver metabolism by hepatic nerves. Adv. Enzyme Regul. 26:63-88.
21. Pocai, A., Obici, S., Schwartz, G., and Rossetti, L. 2005. A brain-liver circuit regulates glucose homeostasis. Cell Metab. 1:53-61.
22. Magnusson, I., Rothman, D.L., Katz, L.D., Shulman, R.G., and Shulman, G.I. 1992. Increased rate of gluconeogenesis in type-II diabetes-mellitus. A 13C nuclear magnetic resonance study. J. Clin. Invest. 90:1323-1327.
23. Reaven, G.M., Chen, Y.D.I., Golay, A., Swislocki, A.L., and Jaspan, J.B. 1987. Documentation of hyperglucagonemia throughout the day in non-obese and obese patients with non-insulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 64:106-110.
24. Granner, D.K., and Pilkis, S.J. 1990. The genes of hepatic glucose metabolism. J. Biol. Chem. 265:10173-10176.
25. Drucker, D.J. 2002. Biologic actions and therapeutic potential of the proglucagon-derived peptides. Gastroenterology. 122:531-544.