The adenosine A2A antagonist MSX-3 reverses the effort-related effects of dopamine blockade: Differential interaction with D1 and D2 family antagonists

Psychopharmacology

Volumn 203, Issue 3, 2009, Pages 489-499

  Worden, Lila T ^a,b   Shahriari, Mona ^a,c   Farrar, Andrew M ^a   Sink, Kelly S ^a   Hockemeyer, Jörg ^d   Müller, Christa E ^d   Salamone, John D ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^d UNIVERSITY OF BONN   (Germany)

Author keywords

Activation; Behavioral economics; Decision making; Motivation; Operant; Reinforcement; Reward

Indexed keywords

ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; DOPAMINE; DOPAMINE 1 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; ECOPIPAM; ETICLOPRIDE; MSX 3; UNCLASSIFIED DRUG; DOPAMINE 1 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; MSX 3 COMPOUND; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; CORPUS STRIATUM; DECISION MAKING; DOPAMINERGIC TRANSMISSION; DOSE RESPONSE; DRUG EFFECT; EFFECT SIZE; FEEDING BEHAVIOR; FOOD INTAKE; LEVER PRESSING; MALE; MOTIVATION; NERVE CELL; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; REGRESSION ANALYSIS; SPRAGUE DAWLEY RAT; STATISTICAL ANALYSIS; STIMULUS RESPONSE; TASK PERFORMANCE; ANIMAL; BRAIN; DRUG ANTAGONISM; DRUG INTERACTION; INSTRUMENTAL CONDITIONING; METABOLISM;

ANIMALS; BRAIN; CONDITIONING, OPERANT; DOPAMINE; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A2A; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; XANTHINES;

EID: 62749155700     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-008-1396-0     Document Type: Article

References (81)

1. JE Aberman JD Salamone 1999 Nucleus accumbens dopamine depletions make rats more sensitive to high ratio requirements but do not impair primary food reinforcement Neuroscience 92 545 552 doi:10.1016/S0306-4522(99)00004-4
2. 3H]SCH23390 J Chem Neuroanat 5 357 366
3. BA Baldo AE Kelley 2007 Discrete neurochemical coding of distinguishable motivational processes: insights from nucleus accumbens control of feeding Psychopharmacology (Berl) 191 439 459
4. MF Barbano M Cador 2007 Opioids for hedonic experience and dopamine to get ready for it Psychopharmacology 191 497 506
5. L Capuron G Pagnoni MF Demetrashvili DH Lawson FB Fornwalt B Woolwine GS Berns S Gregory CB Nemeroff AH Miller 2007 Basal ganglia hypermetabolism and symptoms of fatigue during interferon-alpha therapy Neuropsychopharmacology 32 2384 2392 doi:10.1038/sj.npp.1301362
6. PG Clifton 1995 Effects of SCH39166 and domperidone on the meal patterning of male rats Pharmacol Biochem Behav 52 265 270
7. PG Clifton IN Rusk SJ Cooper 1991 Effects of dopamine D1 and dopamine D2 antagonists on the free feeding and drinking patterns of rats Behav Neurosci 105 272 281
8. M Correa BB Carlson A Wisniecki JD Salamone 2002 Nucleus accumbens dopamine and work requirements on interval schedules Behav Brain Res 137 179 187 doi:10.1016/S0166-4328(02)00292-9
9. M Correa A Wisniecki A Betz DR Dobson MF O'Neill MJ O'Neill JD Salamone 2004 The adenosine A2A antagonist KF17837 reverses the locomotor suppression and tremulous jaw movements induced by haloperidol in rats: possible relevance to parkinsonism Behav Brain Res 148 47 54 doi:10.1016/S0166-4328(03)00178-5
10. MS Cousins JD Salamone 1994 Nucleus accumbens dopamine depletions in rats affect relative response allocation in a novel cost/benefit procedure Pharmacol Biochem Behav 49 85 91 doi:10.1016/0091-3057(94)90460-X
11. MS Cousins JD Sokolowski JD Salamone 1993 Different effects of nucleus accumbens and ventrolateral striatal dopamine depletions on instrumental response selection in the rat Pharmacol Biochem Behav 46 953 951 doi:10.1016/0091-3057(93)90226-J
12. MS Cousins W Wei JD Salamone 1994 Pharmacological characterization of performance on a concurrent lever pressing/feeding choice procedure: effects of dopamine antagonist, cholinomimetic, sedative and stimulant drugs Psychopharmacology 116 529 537 doi:10.1007/BF02247489
13. MS Cousins A Atherton L Turner JD Salamone 1996 Nucleus accumbens dopamine depletions alter relative response allocation in a T-maze cost/benefit task Behav Brain Res 74 189 197 doi:10.1016/0166-4328(95)00151-4
14. EM DeMet A Chicz-DeMet 2002 Localization of adenosine A2A-receptors in rat brain with [3H]ZM-241385 Naunyn Schmiedebergs Arch Pharmacol 366 478 481 doi:10.1007/s00210-002-0613-3
15. K Demyttenaere J De Fruyt SM Stahl 2005 The many faces of fatigue in major depressive disorder Int J Neuropsychopharmacol 8 93 105 doi:10.1017/S1461145704004729
16. F Denk ME Walton KA Jennings T Sharp MF Rushworth DM Bannerman 2005 Differential involvement of serotonin and dopamine systems in cost-benefit decisions about delay or effort Psychopharmacology 179 587 596 doi:10.1007/s00213-004-2059-4
17. AM Farrar M Pereira F Velasco J Hockemeyer CE Muller JD Salamone 2007 Adenosine A(2A) receptor antagonism reverses the effects of dopamine receptor antagonism on instrumental output and effort-related choice in the rat: implications for studies of psychomotor slowing Psychopharmacology 191 579 586 doi:10.1007/s00213-006-0554-5
18. A agonist muscimol into ventral pallidum alters response allocation in food-seeking behavior Neuroscience 152 321 330
19. S Ferré 1997 Adenosine-dopamine interactions in the ventral striatum. Implications for the treatment of schizophrenia Psychopharmacology 133 107 120 doi:10.1007/s002130050380
20. S Ferré BB Fredholm M Morelli P Popoli K Fuxe 1997 Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia Trends Neurosci 20 482 487 doi:10.1016/S0166-2236(97)01096-5
21. S Ferré P Popoli L Giménez-Llort R Rimondini CE Müller I Strömberg SO Ögren K Fuxe 2001 Adenosine/dopamine interaction: implications for the treatment of Parkinson's disease Parkinsonism Relat Disord 7 3 235 241 doi:10.1016/S1353-8020(00)00063-8
22. S Ferré F Ciruela M Canals D Marcellino J Burgueno V Casado J Hillion M Torvinen F Fanelli P Benedetti Pd SR Goldberg M Bouvier K Fuxe LF Agnati C Lluis R Franco A Woods 2004 Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders Parkinsonism Relat Disord 10 265 271 doi:10.1016/j.parkreldis.2004.02.014
23. S Ferre F Ciruela J Borycz M Solinas D Quarta K Antoniou C Quiroz Z Justinova C Lluis R Franco SR Goldberg 2008 Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain Front Biosci 13 2391 2399
24. 2 dopamine receptors in rat striatum Brain Res Mol Brain Res 14 186 195 doi:10.1016/0169-328X(92)90173-9
25. SB Floresco S Ghods-Sharifi 2007 Amygdala-prefrontal cortical circuitry regulates effort-based decision making Cereb Cortex 17 251 260 doi:10.1093/cercor/bhj143
26. SB Floresco MT Tse S Ghods-Sharifi 2008 Dopaminergic and glutamatergic regulation of effort- and delay-based decision making Neuropsychopharmacology 33 1966 1979 doi:10.1038/sj.npp.1301565
27. L Font S Mingote AM Farrar M Pereira L Worden C Stopper RG Port JD Salamone 2008 Intra-accumbens injections of the adenosine A(2A) agonist CGS 21680 affect effort-related choice behavior in rats Psychopharmacology 199 515 526
28. SC Fowler JR Liou 1998 Haloperidol, raclopride, and eticlopride induce microcatalepsy during operant performance in rats, but clozapine and SCH 23390 do not Psychopharmacology 140 81 90
29. K Fuxe LF Agnati K Jacobsen J Hillion M Canals M Torvinen B Tinner-Staines W Staines D Rosin A Terasmaa P Popoli G Leo V Vergoni C Lluis F Ciruela R Franco S Ferré 2003 Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson's disease Neurology 61 S19 S23
30. K Fuxe S Ferré S Genedani R Franco LF Agnati 2007 Adenosine receptor-dopamine receptor interactions in the basal ganglia and their relevance for brain function Physiol Behav 92 210 217
31. 2A receptors in the nucleus accumbens and the caudate-putamen Eur J Pharmacol 323 127 31 doi:10.1016/S0014-2999(97) 00040-X
32. 2A receptors in the caudate putamen of rats Eur J Neurosci 14 1287 1293 doi:10.1046/j.0953-816x.2001.01759.x
33. J Hietala T Seppäla J Lappalainen E Syvälahti 1992 Quantification of SCH 39166, a novel selective D1 dopamine receptor antagonist, in rat brain and blood Psychopharmacology 106 455 458
34. 2 receptors J Biol Chem 277 18091 18097 doi:10.1074/jbc.M107731200
35. J Hockemeyer JC Burbiel CE Muller 2004 Multigram-scale syntheses, stability, and photoreactions of A2A adenosine receptor antagonists with 8-styrylxanthine structure: potential drugs for Parkinson's disease J Org Chem 69 3308 3318
36. 2A antagonist MSX-3 into the nucleus accumbens core attenuate the locomotor suppression induced by haloperidol in rats Behav Brain Res 178 190 199 doi:10.1016/j.bbr.2006.12.020
37. 2A-selective agonist, [3H]CGS 21680 Eur J Pharmacol 168 243 246 doi:10.1016/0014-2999(89)90571-2
38. P Jenner 2003 Dopamine agonists, receptor selectivity and dyskinesia induction in Parkinson's disease Curr Opin Neurol 16 Suppl 1 S3 S7 doi:10.1097/00019052-200312001-00002
39. 2A receptor antagonist, for the treatment of Parkinson's disease Expert Opin Investig Drugs 14 729 738 doi:10.1517/13543784.14.6.729
40. AE Kelley BA Baldo WE Pratt MJ Will 2005 Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward Physiol Behav 86 773 795
41. Keppel G (1991) Design and analysis: a researcher's handbook. Prentice-Hall, Englewood Cliffs, New Jersey
42. 2 receptors in instrumental and Pavlovian paradigms of conditioned reward Psychopharmacology 152 67 73 doi:10.1007/s002130000505
43. M Majer LA Welberg L Capuron G Pagnoni CL Raison AH Miller 2008 IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C Brain Behav Immun 22 870 880 doi:10.1016/j.bbi.2007.12.009
44. S Mingote SM Weber K Ishiwari M Correa JD Salamone 2005 Ratio and time requirements on operant schedules: effort-related effects of nucleus accumbens dopamine depletions Eur J Neurosci 21 1749 1757
45. S Mingote L Font AM Farrar R Vontell LT Worden CM Stopper RG Port KS Sink JG Bunce JJ Chrobak JD Salamone 2008 Nucleus accumbens adenosine A2A receptors regulate exertion of effort by acting on the ventral striatopallidal pathway J Neurosci 28 9037 9046
46. 2A receptors as a basis for the treatment of Parkinson's disease Neurol Sci 22 71 72 doi:10.1007/s100720170052
47. Y Niv ND Daw D Joel P Dayan 2007 Tonic dopamine: opportunity costs and the control of response vigor Psychopharmacology 191 507 520 doi:10.1007/s00213-006-0502-4
48. 2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption Pharmacol Biochem Behav 69 373 382 doi:10.1016/S0091-3057(01)00524-X
49. 2A antagonist KW-6002 on motor and motivational processes in the rat Psychopharmacology 184 46 55 doi:10.1007/s00213-005-0240-z
50. PE Phillips ME Walton TC Jhou 2007 Calculating utility: preclinical evidence for cost-benefit analysis by mesolimbic dopamine Psychopharmacology 191 483 495 doi:10.1007/s00213-006-0626-6
51. A Pinna J Wardas A Cozzolino M Morelli 1999 Involvement of adenosine A2A receptors in the induction of c-fos expression by clozapine and haloperidol Neuropsychopharmacology 20 44 51
52. 2A receptor antagonists Life Sci 77 3259 3267 doi:10.1016/j.lfs.2005.04.029
53. JD Salamone 1991
54. JD Salamone 1992 Complex motor and sensorimotor functions of striatal and accumbens dopamine: involvement in instrumental behavior processes Psychopharmacology 107 160 174 doi:10.1007/BF02245133
55. JD Salamone M Correa 2002 Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine Behav Brain Res 137 3 25
56. JD Salamone RE Steinpreis LD McCullough P Smith D Grebel K Mahan 1991 Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure Psychopharmacology 104 515 521 doi:10.1007/BF02245659
57. JD Salamone MS Cousins S Bucher 1994 Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost/benefit procedure Behav Brain Res 65 221 229 doi:10.1016/0166-4328(94)90108-2
58. JD Salamone MS Cousins C Maio M Champion T Turski J Kovach 1996 Different behavioral effects of haloperidol, clozapine and thioridazine in a concurrent lever pressing and feeding procedure Psychopharmacology 125 105 112 doi:10.1007/BF02249408
59. JD Salamone MS Cousins BJ Snyder 1997 Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis Neurosci Biobehav Rev 21 341 359 doi:10.1016/S0149-7634(96)00017-6
60. JD Salamone M Arizzi MD Sandoval KM Cervone JE Aberman 2002 Dopamine antagonists alter response allocation but do not suppress appetite for food in rats: contrast between the effects of SKF 83566, raclopride and fenfluramine on a concurrent choice task Psychopharmacology 160 371 380 doi:10.1007/s00213-001- 0994-x
61. JD Salamone M Correa S Mingote S Weber 2003 Accumbens dopamine and the regulation of effort in food-seeking behavior: implications for studies of natural motivation and psychiatry J Pharmacol Exp Ther 305 1 8 doi:10.1124/jpet.102.035063
62. JD Salamone M Correa SM Mingote SM Weber 2005 Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine Curr Opin Pharmacol 5 34 41 doi:10.1016/j.coph.2004.09.004
63. JD Salamone M Correa SM Mingote SM Weber AM Farrar 2006 Nucleus accumbens dopamine and the forebrain circuitry involved in behavioral activation and effort-related decision making: implications for understanding anergia and psychomotor slowing in depression Curr Psychiatry Rev 2 267 280 doi:10.2174/157340006776875914
64. JD Salamone M Correa A Farrar SM Mingote 2007 Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits Psychopharmacology 191 461 482 doi:10.1007/s00213-006-0668-9
65. JD Salamone AJ Betz K Ishiwari J Felsted L Madson B Mirante K Clark L Font S Korbey TN Sager J Hockemeyer CE Muller 2008 Tremorolytic effects of adenosine A2A antagonists: implications for parkinsonism Front Biosci 13 3594 3605
66. JD Salamone K Ishiwari AJ Betz AM Farrar SM Mingote L Font J Hockemeyer CE Müller M Correa 2008 Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism Parkinsonism Relat Disord 14 S130 S134
67. 2A receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study J Neurochem 57 1062 1071 doi:10.1111/j.1471-4159.1991.tb08257.x
68. J Schweimer W Hauber 2006 Involvement of the rat anterior cingulate cortex in control of instrumental responses guided by reward expectancy Learn Mem 12 334 342 doi:10.1101/lm.90605
69. J Schweimer S Saft W Hauber 2005 Involvement of catecholamine neurotransmission in the rat anterior cingulate in effort-related decision making Behav Neurosci 119 1687 1692 doi:10.1037/0735-7044.119.6.1687
70. KS Sink VK Vemuri T Olszewska A Makriyannis JD Salamone 2008 Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior Psychopharmacology 196 565 574 doi:10.1007/s00213-007-0988-4
71. JD Sokolowski JD Salamone 1998 The role of nucleus accumbens dopamine in lever pressing and response allocation: effects of 6-OHDA injected into core and dorsomedial shell Pharmacol Biochem Behav 59 557 566 doi:10.1016/S0091-3057(97) 00544-3
72. SM Stahl 2002 The psychopharmacology of energy and fatigue J Clin Psychiatry 63 7 8
73. 2A receptors Prog Neurobiol 59 355 396 doi:10.1016/S0301-0082(99)00011-8
74. RN Takahashi FA Pamplona RD Prediger 2008 Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies Front Biosci 13 2614 2632
75. A Tylee M Gastpar JP Lepine J Mendlewicz 1999 DEPRES II (Depression Research in European Society II): a patient survey of the symptoms, disability and current management of depression in the community Int Clin Psychopharmacol 14 139 151 doi:10.1097/00004850-199905002-00001
76. R Van den Bos J van der Harst S Jonkman M Schilders B Spruijt 2006 Rats assess costs and benefits according to an internal standard Behav Brain Res 171 350 354 doi:10.1016/j.bbr.2006.03.035
77. ME Walton DM Bannerman MF Rushworth 2002 The role of rat medial frontal cortex in effort-based decision making J Neurosci 22 10996 11003
78. ME Walton DM Bannerman K Alterescu MF Rushworth 2003 Functional specialization within medial frontal cortex of the anterior cingulate for evaluating effort-related decisions J Neurosci 23 6475 6479
79. ME Walton SW Kennerley DM Bannerman PE Phillips MF Rushworth 2006 Weighing up the benefits of work: behavioral and neural analyses of effort-related decision making Neural Netw 19 1302 1314 doi:10.1016/j.neunet. 2006.03.005
80. 2A adenosine receptor antagonist, counteracts parkinsonian-like muscle rigidity in rats Synapse 41 160 171 doi:10.1002/syn.1070
81. DA Yurgelun-Todd S Sava MK Dahlgren 2007 Mood disorders Neuroimaging Clin N Am 17 511 521 doi:10.1016/j.nic.2007.08.001