Motor depressant effects mediated by dopamine D2 and adenosine A(2A) receptors in the nucleus accumbens and the caudate-putamen

European Journal of Pharmacology

Volumn 323, Issue 2-3, 1997, Pages 127-131

  Hauber, Wolfgang ^a   Münkle, Manuela ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

Author keywords

Adenosine A(2A) receptor; Catalepsy; Dopamine D2 receptor; Locomotion; Rat; Striatum

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE A2A RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; RACLOPRIDE;

ANIMAL EXPERIMENT; ARTICLE; CATALEPSY; CENTRAL NERVOUS SYSTEM DEPRESSION; CONTROLLED STUDY; CORPUS STRIATUM; INTRACEREBRAL DRUG ADMINISTRATION; LOCOMOTION; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PUTAMEN; RAT;

ADENOSINE; ANIMALS; CATALEPSY; CAUDATE NUCLEUS; MALE; MICROINJECTIONS; MOTOR ACTIVITY; NEOSTRIATUM; NUCLEUS ACCUMBENS; PHENETHYLAMINES; PUTAMEN; RACLOPRIDE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A2A; RECEPTORS, DOPAMINE D2; RECEPTORS, PURINERGIC P1; SALICYLAMIDES;

EID: 0343471417     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00040-X     Document Type: Article

References (21)

1. Amalric, M., Koob, G.F., 1987. Depletion of dopamine in the caudate nucleus but not in nucleus accumbens impairs reaction-time performance in rats. J. Neurosci. 7, 2129-2134.
2. 2a receptors in the nucleus accumbens. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 18, 545-553.
3. 2-dopamine receptor-mediated catalepsy. Brain Res. 450, 403-407.
4. Collis, M.G., Hourani, S.M.O., 1993. Adenosine receptor subtypes. Trends Pharmacol. Sci. 14, 360-366.
5. 2 receptors induces catalepsy. Neurosci. Lett. 130, 162-164.
6. Ferré, S., O'Connor, W.T., Fuxe, K., Ungerstedt, U., 1993. The striopallidal neuron - a main locus for adenosine-dopamine interactions in the brain. J. Neurosci. 13, 5402-5406.
7. 2 receptors in the ventral striopallidal system. Implications for the treatment of schizophrenia. Neuroscience 63, 765-773.
8. 2 receptor interactions in the basal ganglia: analysis from the network to the molecular level. In: Bellardinelli, L. and Pelleg, A. (Eds.), Adenosine and Adenine Nucleotides: from Molecular Biology to Integrative Physiology. Kluwer Academic, Boston, MA.
9. 2a receptors in the rat striatum induces catalepsy that is reversed by antagonists of N-methy-D-aspartate receptors. Neurosci. Lett. 196, 205-208.
10. Jackson, D.M., Ryan, C., Evenden, J., Mohell, J., 1994. Preclinical findings with new antipsychotic agents - what makes them atypical? Acta Psychiatr. Scand. 89, 41-48.
11. 3H]CGS21680. Eur. J. Pharmacol. 168, 243-248.
12. 2 receptor interactions in animal models of schizophrenia. Eur. J. Pharmacol. 295, 147-154.
13. Kelly, P.S., Seviour, P.W., Iversen, S.D., 1975. Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Res. 94, 507-522.
14. 2 receptors in unilaterally 6-hydroxydopamine-lesioned rats. Eur. J. Pharmacol. 251, 21-25.
15. 2 dopamine receptors in neuroleptic catalepsy. Eur. J. Pharmacol. 182, 327-334.
16. Paxinos, G., Watson, G., 1986. The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego.
17. Pellegrino, L.J., Pellegrino, A.S., Cushman, A.J., 1981. A Stereotaxic Atlas of the Rat Brain. Plenum Press, New York.
18. 2 receptor (RDC8) is expressed by enkeplalin but not by substance P neurons: an in-situ hybridization histochemistry study. J. Neurochem. 57, 1062-1067.
19. Svenningsson, P., Nomikos, G.G., Fredholm, B.B., 1995. Biphasic changes in locomotor behaviour and in expression of mRNA for NGF-A and NGF-B in rat striatum following acute caffeine administration. J. Neurosci. 15, 7612-7624.
20. 2-antagonist raclopride in the nucleus accumbens of the rat on spontaneous and d-amphetamine-induced activity. Psychopharmacology 95, 447-451.
21. 2 receptor regulation of apomorphine-induced turning in rats with unilateral striatal dopamine denervation. Psychopharmacology 111, 383-388.