(n-3) fatty acid content of red blood cells does not predict risk of future cardiovascular events following an acute coronary syndrome

Journal of Nutrition

Volumn 139, Issue 3, 2009, Pages 507-513

  Aarsetoey, Hildegunn ^a,b   Pönitz, Volker ^a,b   Grundt, Heidi ^a,b   Staines, Harry ^c   Harris, William S ^d   Nilsen, Dennis W T ^a,b  

^a STAVANGER UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

^c Sigma Statistical Services   (United Kingdom)

^d UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; CREATININE; DOCOSAHEXAENOIC ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; ICOSAPENTAENOIC ACID; TRIACYLGLYCEROL; TROPONIN T; OMEGA 3 FATTY ACID;

ACUTE CORONARY SYNDROME; ADULT; AGED; BODY MASS; CARDIOVASCULAR RISK; CAUSE OF DEATH; CELLULAR DISTRIBUTION; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONFERENCE PAPER; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DISEASE MARKER; ERYTHROCYTE; FEMALE; FOLLOW UP; GENDER; GROUPS BY AGE; HEART DEATH; HEART DISEASE; HEART INFARCTION; HOSPITALIZATION; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROTEIN BLOOD LEVEL; RECURRENT DISEASE; SMOKING; TRIACYLGLYCEROL BLOOD LEVEL; ARTICLE; BLOOD; CHEMISTRY; MIDDLE AGED; MORTALITY; RISK FACTOR; SUDDEN DEATH;

ACUTE CORONARY SYNDROME; ADULT; AGED; AGED, 80 AND OVER; DEATH, SUDDEN, CARDIAC; ERYTHROCYTES; FATTY ACIDS, OMEGA-3; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; RISK FACTORS;

EID: 62749106798     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.108.096446     Document Type: Conference Paper

References (33)

1. Harris WS, von Schacky C. The omega-3 index: a new risk factor for death from coronary heart disease. Prev Med. 2004;39:212-20.
2. Harris WS. Omega-3 fatty acids and cardiovascular disease: a case for omega-3 index as a new risk factor. Pharmacol Res. 2007;55:217-23.
3. Mozaffarian D, Rimm EB. Fish intake, contaminants and human health. Evaluating the risks and benefits. JAMA. 2006;296:18 85-99.
4. Kris-Etherton PM, Harris WS, Appel LJ, for the Nutrition Committee. Fish consumption, fish oil, omega-3 fatty acids and cardiovascular disease. Arterioscler Thromb Vasc Biol. 2003;23:e20-31.
5. Smith SC Jr, Allen J, Blair SN, Bonow RO, Brass LM, Fonarow GC, Grundy SM, Hiratzka L, Jones D, et al. AHA/ACC guidelines for secondary prevention for patients with coronary and other atheroscle rotic vascular disease: 2006 update. Circulation. 2006;113:2363-72.
6. De Backer G, Ambrosioni E, Borch-Johnsen K, Brotons C, Cifkova R, Dallongeville J, Ebrahim S, Faergeman O, Graham I, et al. European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force for European and Other Societies on Cardio vascular Disease Prevention in Clinical Practice. Eur Heart J. 2003;24: 1601-10.
7. Priori SG, Aliot E, Blomstrom-Lundqvist C, Bossaert L, Breithardt G, Brugada P, Camm JA, Cappato R, Cobbe SM, et al., for European Society of Cardiology. Update of the guidelines on sudden cardiac death of the European Society of Cardiology. Eur Heart J. 2003;24:13-5.
8. Von Schacky C, Harris WS. Cardiovascular benefits of omega-3 fatty acids. Cardiovasc Res. 2007;73:310-5.
9. Sands SA, Reid KJ, Windsor SL, Harris WS. The impact of age, body mass index and fish intake on the EPA and DHA content of human erythrocytes. Lipids. 2005;40:343-7.
10. Mozaffarian D, Lemaitre R, Kuller LH, Burke GL, Tracy RP, Siscovick DS. Cardiac benefits of fish consumption may depend on the type of fish meal consumed. The Cardiovascular Health Study. Circulation. 2003;107: 1372-7.
11. Cao J, Schwichtenberg KA, Hanson NQ, Tsai MY. Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. Clin Chem. 2006;52:2265-72.
12. Metcalf RG, James MJ, Gibson RA, Edwards RJ, Stubberfield J, Stuklis R, Roberts-Thomson K, Young GD, Cleland LG. Effects of fish-oil supplementation on myocardial fatty acids in humans. Am J Clin Nutr. 2007;85:1222-8.
13. Leaf A, Xiao Y-F, Kang JX, Billman GE. Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids. Pharmacol Ther. 2003;98:355-77.
14. Siddiqui RA, Harvey KA, Zaloga GP. Modulation of enzymatic activities by n-3 polyunsaturated fatty acids to support cardiovascular health. J Nutr Biochem. 2008;19:417-37.
15. Khan SA, Vanden Heuvel. Reviews: current topics. Role of nuclear receptors in the regulation of gene expression by dietary fatty acids. J Nutr Biochem. 2003;14:554-67.
16. Robinson JG, Stone NJ. Antiatherosclerotic and antithrombotic effects of omega-3 fatty acids. Am J Cardiol. 2006;98 Suppl:i39-49.
17. Reiffel JA, McDonald A. Antiarrhythmic effects of omega-3 fatty acids. Am J Cardiol. 2006;98 Suppl:i50-60.
18. Harris WS, Sands SA, Windsor SL, Ali HA, Stevens TL, Magalski A, Porter CB, Borkon AM. Omega-3 fatty acids in cardiac biopsies from heart transplantation patients. Correlation with erythrocytes and response to supplementation. Circulation. 2004;110:1645-9.
19. Owen AJ, Peter-Przyborowska BA, Hoy AJ, McLennan PL. Dietary fish oil dose- and time-response effects on cardiac phospholipid fatty acid composition. Lipids. 2004;39:955-61.
20. Siscovick DS, Raghunathan TE, King I, Weinmann S, Wicklund KG, Albright J, Bovbjerg V, Arbogast P, Smith H, et al. Dietary intake and cell membrane levels of long chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. JAMA. 1995;274:1363-7.
21. Block RC, Harris WS, Reid KJ, Sands SA, Spertus JA. EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls. Atherosclerosis. 2008;197:821-8.
22. Paganelli F, Maixent J-M, Duran M-J, Parhizgar R, Pieroni G, Sennoune S. Altered erythrocyte n-3 fatty acids in Mediterranean patients with coronary artery disease. Int J Cardiol. 2001;78:27-32.
23. Aarsetøy H, Pönitz V, Nilsen OB, Grundt H, Harris WS, Nilsen DWT. Low levels of cellular omega-3 increases the risk of ventricular fibrillation during the acute ischaemic phase of a myocardial infarction. Resuscitation. 2008;78:258-64.
24. Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, et al., for the Japan EPA lipid intervention study (JELIS) Investigators. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 2007;369:1090-8.
25. Nilsen DWT, Albrektsen G, Landmark K, Moen S, Aarsland T, Woie L. Effects of a high-dose concentrate of n-3 fatty acids or corn oil introduced early after an acute myocardial infarction on serum triacylglycerol and HDL cholesterol. Am J Clin Nutr. 2001;74:50-6.
26. Siscovick DS, Raghunathan T, King I, Weinmann S, Bovbjerg VE, Kushi L, Cobb LA, Copass MK, Psaty BM, et al. Dietary intake of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. Am J Clin Nutr. 2000;71 Suppl:S208-12.
27. Harris W Omega-3 fatty acids: the "Japanese" factor? J Am Coll Cardiol. 2008;52:425-7.
28. Ness AR, Ashfield-Watt PAL, Whiting JM, Smith GD, Hughess J, Burr ML. The long-term effect of dietary advice on the diet of men with angina: the diet and angina randomized trial. J Hum Nutr Diet. 2004; 17:117-9.
29. Cohen BE, Garg SK, Ali S, Harris WS, Whooley MA. Red blood cell docosahexaenoic acid and eicosapentaenoic acid concentrations are positively associated with socioeconomic status in patients with established coronary artery disease: data from the Heart and Soul Study. J Nutr. 2008;138:1135-40.
30. Salonen JT, Seppanen K, Nyyssönen K, Korpela H, Kauhanen J, Kantola M, Tuomilehto J, Esterbauer H, Tatzber F, et al. Intake of mercury from fish, lipid peroxidation and the risk of myocardial infarction and coronary, cardiovascular and any death in eastern Finnish men. Circulation. 1995;91:645-55.
31. Burr ML, Ashfield-Watt PAL, Dunstan FD, Fehily AM, Breay P, Ashton T, Zotos PC, Haboubi NA, Elwood PC. Lack of benefit of dietary advice to men with angina: results of a controlled trial. Eur J Clin Nutr. 2003;57:193-200.
32. Salonen JT, Seppanen K, Lakka TA, Salonen R, Kaplan GA. Mercury accumulation and accelerated progression of carotid atherosclerosis: a population-based prospective 4-year follow-up study in men in eastern Finland. Atherosclerosis. 2000;148:265-73.
33. Kark JD, Manor O, Goldman S, Berry EM. Stability of red blood cell membrane fatty acid composition after acute myocardial infarction. J Clin Epidemiol. 1995;48:889-95.